diff --git a/article_jres_olivier_amoi.fodt b/article_jres_olivier_amoi.fodt
index 7a657a4..72e353f 100644
--- a/article_jres_olivier_amoi.fodt
+++ b/article_jres_olivier_amoi.fodt
@@ -1,30 +1,29 @@
 <?xml version="1.0" encoding="UTF-8"?>
 
 <office:document xmlns:officeooo="http://openoffice.org/2009/office" xmlns:css3t="http://www.w3.org/TR/css3-text/" xmlns:grddl="http://www.w3.org/2003/g/data-view#" xmlns:xhtml="http://www.w3.org/1999/xhtml" xmlns:formx="urn:openoffice:names:experimental:ooxml-odf-interop:xmlns:form:1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:chart="urn:oasis:names:tc:opendocument:xmlns:chart:1.0" xmlns:svg="urn:oasis:names:tc:opendocument:xmlns:svg-compatible:1.0" xmlns:text="urn:oasis:names:tc:opendocument:xmlns:text:1.0" xmlns:oooc="http://openoffice.org/2004/calc" xmlns:style="urn:oasis:names:tc:opendocument:xmlns:style:1.0" xmlns:ooow="http://openoffice.org/2004/writer" xmlns:meta="urn:oasis:names:tc:opendocument:xmlns:meta:1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rpt="http://openoffice.org/2005/report" xmlns:draw="urn:oasis:names:tc:opendocument:xmlns:drawing:1.0" xmlns:config="urn:oasis:names:tc:opendocument:xmlns:config:1.0" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:fo="urn:oasis:names:tc:opendocument:xmlns:xsl-fo-compatible:1.0" xmlns:ooo="http://openoffice.org/2004/office" xmlns:office="urn:oasis:names:tc:opendocument:xmlns:office:1.0" xmlns:dr3d="urn:oasis:names:tc:opendocument:xmlns:dr3d:1.0" xmlns:table="urn:oasis:names:tc:opendocument:xmlns:table:1.0" xmlns:number="urn:oasis:names:tc:opendocument:xmlns:datastyle:1.0" xmlns:of="urn:oasis:names:tc:opendocument:xmlns:of:1.2" xmlns:calcext="urn:org:documentfoundation:names:experimental:calc:xmlns:calcext:1.0" xmlns:tableooo="http://openoffice.org/2009/table" xmlns:drawooo="http://openoffice.org/2010/draw" xmlns:loext="urn:org:documentfoundation:names:experimental:office:xmlns:loext:1.0" xmlns:dom="http://www.w3.org/2001/xml-events" xmlns:field="urn:openoffice:names:experimental:ooo-ms-interop:xmlns:field:1.0" xmlns:math="http://www.w3.org/1998/Math/MathML" xmlns:form="urn:oasis:names:tc:opendocument:xmlns:form:1.0" xmlns:script="urn:oasis:names:tc:opendocument:xmlns:script:1.0" xmlns:xforms="http://www.w3.org/2002/xforms" office:version="1.3" office:mimetype="application/vnd.oasis.opendocument.text">
- <office:meta><meta:creation-date>2021-02-15T09:17:10.478673722</meta:creation-date><meta:editing-duration>PT4H50M41S</meta:editing-duration><meta:editing-cycles>52</meta:editing-cycles><meta:generator>LibreOffice/7.2.4.1$Linux_X86_64 LibreOffice_project/20$Build-1</meta:generator><dc:subject>Modèle et mini-guide</dc:subject><dc:title>Modèle Jres 2021</dc:title><dc:date>2022-01-07T01:28:07.900329662</dc:date><dc:creator>eda</dc:creator><meta:document-statistic meta:table-count="0" meta:image-count="1" meta:object-count="0" meta:page-count="7" meta:paragraph-count="96" meta:word-count="2331" meta:character-count="15893" meta:non-whitespace-character-count="13650"/></office:meta>
+ <office:meta><meta:creation-date>2021-02-15T09:17:10.478673722</meta:creation-date><meta:editing-duration>PT9H44M46S</meta:editing-duration><meta:editing-cycles>122</meta:editing-cycles><meta:generator>LibreOffice/7.0.4.2$Linux_X86_64 LibreOffice_project/00$Build-2</meta:generator><dc:subject>Modèle et mini-guide</dc:subject><dc:title>Modèle Jres 2021</dc:title><dc:date>2022-01-07T17:23:50.034061293</dc:date><meta:document-statistic meta:table-count="0" meta:image-count="2" meta:object-count="0" meta:page-count="9" meta:paragraph-count="114" meta:word-count="3042" meta:character-count="20488" meta:non-whitespace-character-count="17537"/></office:meta>
  <office:settings>
   <config:config-item-set config:name="ooo:view-settings">
-   <config:config-item config:name="ViewAreaTop" config:type="long">131979</config:config-item>
+   <config:config-item config:name="ViewAreaTop" config:type="long">0</config:config-item>
    <config:config-item config:name="ViewAreaLeft" config:type="long">0</config:config-item>
-   <config:config-item config:name="ViewAreaWidth" config:type="long">24825</config:config-item>
-   <config:config-item config:name="ViewAreaHeight" config:type="long">14169</config:config-item>
+   <config:config-item config:name="ViewAreaWidth" config:type="long">41083</config:config-item>
+   <config:config-item config:name="ViewAreaHeight" config:type="long">17538</config:config-item>
    <config:config-item config:name="ShowRedlineChanges" config:type="boolean">false</config:config-item>
    <config:config-item config:name="InBrowseMode" config:type="boolean">false</config:config-item>
    <config:config-item-map-indexed config:name="Views">
     <config:config-item-map-entry>
      <config:config-item config:name="ViewId" config:type="string">view2</config:config-item>
-     <config:config-item config:name="ViewLeft" config:type="long">6546</config:config-item>
-     <config:config-item config:name="ViewTop" config:type="long">137668</config:config-item>
+     <config:config-item config:name="ViewLeft" config:type="long">10356</config:config-item>
+     <config:config-item config:name="ViewTop" config:type="long">2925</config:config-item>
      <config:config-item config:name="VisibleLeft" config:type="long">0</config:config-item>
-     <config:config-item config:name="VisibleTop" config:type="long">131979</config:config-item>
-     <config:config-item config:name="VisibleRight" config:type="long">24823</config:config-item>
-     <config:config-item config:name="VisibleBottom" config:type="long">146147</config:config-item>
+     <config:config-item config:name="VisibleTop" config:type="long">0</config:config-item>
+     <config:config-item config:name="VisibleRight" config:type="long">41081</config:config-item>
+     <config:config-item config:name="VisibleBottom" config:type="long">17537</config:config-item>
      <config:config-item config:name="ZoomType" config:type="short">0</config:config-item>
-     <config:config-item config:name="ViewLayoutColumns" config:type="short">0</config:config-item>
+     <config:config-item config:name="ViewLayoutColumns" config:type="short">1</config:config-item>
      <config:config-item config:name="ViewLayoutBookMode" config:type="boolean">false</config:config-item>
-     <config:config-item config:name="ZoomFactor" config:type="short">110</config:config-item>
+     <config:config-item config:name="ZoomFactor" config:type="short">100</config:config-item>
      <config:config-item config:name="IsSelectedFrame" config:type="boolean">false</config:config-item>
-     <config:config-item config:name="KeepRatio" config:type="boolean">false</config:config-item>
      <config:config-item config:name="AnchoredTextOverflowLegacy" config:type="boolean">false</config:config-item>
     </config:config-item-map-entry>
    </config:config-item-map-indexed>
@@ -47,8 +46,7 @@
    <config:config-item config:name="DisableOffPagePositioning" config:type="boolean">false</config:config-item>
    <config:config-item config:name="SubtractFlysAnchoredAtFlys" config:type="boolean">false</config:config-item>
    <config:config-item config:name="PropLineSpacingShrinksFirstLine" config:type="boolean">true</config:config-item>
-   <config:config-item config:name="ApplyParagraphMarkFormatToNumbering" config:type="boolean">false</config:config-item>
-   <config:config-item config:name="GutterAtTop" config:type="boolean">false</config:config-item>
+   <config:config-item config:name="ApplyParagraphMarkFormatToNumbering" config:type="boolean">true</config:config-item>
    <config:config-item config:name="TreatSingleColumnBreakAsPageBreak" config:type="boolean">false</config:config-item>
    <config:config-item config:name="EmbedSystemFonts" config:type="boolean">false</config:config-item>
    <config:config-item config:name="EmbedComplexScriptFonts" config:type="boolean">false</config:config-item>
@@ -60,11 +58,11 @@
    <config:config-item config:name="ClippedPictures" config:type="boolean">false</config:config-item>
    <config:config-item config:name="FloattableNomargins" config:type="boolean">false</config:config-item>
    <config:config-item config:name="UnbreakableNumberings" config:type="boolean">false</config:config-item>
-   <config:config-item config:name="HeaderSpacingBelowLastPara" config:type="boolean">false</config:config-item>
+   <config:config-item config:name="HeaderSpacingBelowLastPara" config:type="boolean">true</config:config-item>
    <config:config-item config:name="AllowPrintJobCancel" config:type="boolean">true</config:config-item>
    <config:config-item config:name="UseOldPrinterMetrics" config:type="boolean">false</config:config-item>
    <config:config-item config:name="TabOverMargin" config:type="boolean">false</config:config-item>
-   <config:config-item config:name="TabsRelativeToIndent" config:type="boolean">true</config:config-item>
+   <config:config-item config:name="TabsRelativeToIndent" config:type="boolean">false</config:config-item>
    <config:config-item config:name="UseOldNumbering" config:type="boolean">false</config:config-item>
    <config:config-item config:name="InvertBorderSpacing" config:type="boolean">false</config:config-item>
    <config:config-item config:name="PrintPaperFromSetup" config:type="boolean">false</config:config-item>
@@ -72,7 +70,6 @@
    <config:config-item config:name="CurrentDatabaseCommandType" config:type="int">0</config:config-item>
    <config:config-item config:name="LinkUpdateMode" config:type="short">1</config:config-item>
    <config:config-item config:name="AddParaSpacingToTableCells" config:type="boolean">true</config:config-item>
-   <config:config-item config:name="FrameAutowidthWithMorePara" config:type="boolean">false</config:config-item>
    <config:config-item config:name="CurrentDatabaseCommand" config:type="string"/>
    <config:config-item config:name="PrinterIndependentLayout" config:type="string">high-resolution</config:config-item>
    <config:config-item config:name="ApplyUserData" config:type="boolean">true</config:config-item>
@@ -97,7 +94,7 @@
    </config:config-item-map-indexed>
    <config:config-item config:name="PrinterSetup" config:type="base64Binary"/>
    <config:config-item config:name="AddParaTableSpacingAtStart" config:type="boolean">true</config:config-item>
-   <config:config-item config:name="Rsid" config:type="int">8293284</config:config-item>
+   <config:config-item config:name="Rsid" config:type="int">13166436</config:config-item>
    <config:config-item config:name="EmbeddedDatabaseName" config:type="string"/>
    <config:config-item config:name="FieldAutoUpdate" config:type="boolean">true</config:config-item>
    <config:config-item config:name="OutlineLevelYieldsNumbering" config:type="boolean">false</config:config-item>
@@ -110,12 +107,11 @@
    <config:config-item config:name="AddParaLineSpacingToTableCells" config:type="boolean">false</config:config-item>
    <config:config-item config:name="UseFormerObjectPositioning" config:type="boolean">false</config:config-item>
    <config:config-item config:name="PrintGraphics" config:type="boolean">true</config:config-item>
-   <config:config-item config:name="SurroundTextWrapSmall" config:type="boolean">false</config:config-item>
+   <config:config-item config:name="SurroundTextWrapSmall" config:type="boolean">true</config:config-item>
    <config:config-item config:name="ConsiderTextWrapOnObjPos" config:type="boolean">false</config:config-item>
    <config:config-item config:name="MsWordCompTrailingBlanks" config:type="boolean">false</config:config-item>
-   <config:config-item config:name="TabAtLeftIndentForParagraphsInList" config:type="boolean">false</config:config-item>
+   <config:config-item config:name="TabAtLeftIndentForParagraphsInList" config:type="boolean">true</config:config-item>
    <config:config-item config:name="PrintRightPages" config:type="boolean">true</config:config-item>
-   <config:config-item config:name="TabOverSpacing" config:type="boolean">false</config:config-item>
    <config:config-item config:name="IgnoreFirstLineIndentInNumbering" config:type="boolean">false</config:config-item>
    <config:config-item config:name="RedlineProtectionKey" config:type="base64Binary"/>
    <config:config-item config:name="DoNotJustifyLinesWithManualBreak" config:type="boolean">false</config:config-item>
@@ -133,7 +129,7 @@
    <config:config-item config:name="RsidRoot" config:type="int">376182</config:config-item>
    <config:config-item config:name="PrintHiddenText" config:type="boolean">false</config:config-item>
    <config:config-item config:name="ProtectForm" config:type="boolean">false</config:config-item>
-   <config:config-item config:name="MsWordCompMinLineHeightByFly" config:type="boolean">false</config:config-item>
+   <config:config-item config:name="MsWordCompMinLineHeightByFly" config:type="boolean">true</config:config-item>
    <config:config-item config:name="BackgroundParaOverDrawings" config:type="boolean">false</config:config-item>
    <config:config-item config:name="SaveVersionOnClose" config:type="boolean">false</config:config-item>
    <config:config-item config:name="MathBaselineAlignment" config:type="boolean">true</config:config-item>
@@ -144,33 +140,34 @@
  </office:settings>
  <office:scripts>
   <office:script script:language="ooo:Basic">
-   <ooo:libraries xmlns:ooo="http://openoffice.org/2004/office" xmlns:xlink="http://www.w3.org/1999/xlink">
-    <ooo:library-embedded ooo:name="Standard"/>
-   </ooo:libraries>
+   <ooo:libraries xmlns:ooo="http://openoffice.org/2004/office" xmlns:xlink="http://www.w3.org/1999/xlink"/>
   </office:script>
  </office:scripts>
  <office:font-face-decls>
-  <style:font-face style:name="Arial" svg:font-family="Arial" style:font-adornments="Gras Italique" style:font-family-generic="swiss" style:font-pitch="variable"/>
-  <style:font-face style:name="Courier New" svg:font-family="&apos;Courier New&apos;" style:font-family-generic="modern" style:font-pitch="fixed"/>
-  <style:font-face style:name="FreeSans" svg:font-family="FreeSans" style:font-family-generic="system" style:font-pitch="variable"/>
   <style:font-face style:name="FreeSans1" svg:font-family="FreeSans" style:font-family-generic="swiss"/>
+  <style:font-face style:name="Courier New" svg:font-family="&apos;Courier New&apos;" style:font-family-generic="modern" style:font-pitch="fixed"/>
   <style:font-face style:name="Liberation Mono" svg:font-family="&apos;Liberation Mono&apos;" style:font-adornments="Normal" style:font-family-generic="modern" style:font-pitch="fixed"/>
-  <style:font-face style:name="Liberation Sans" svg:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="swiss" style:font-pitch="variable"/>
+  <style:font-face style:name="Arial" svg:font-family="Arial" style:font-family-generic="roman" style:font-pitch="variable"/>
+  <style:font-face style:name="Liberation Sans1" svg:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable"/>
   <style:font-face style:name="Liberation Serif" svg:font-family="&apos;Liberation Serif&apos;" style:font-family-generic="roman" style:font-pitch="variable"/>
+  <style:font-face style:name="OpenSymbol" svg:font-family="OpenSymbol" style:font-family-generic="roman" style:font-pitch="variable"/>
+  <style:font-face style:name="Liberation Sans" svg:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="swiss" style:font-pitch="variable"/>
+  <style:font-face style:name="Liberation Serif1" svg:font-family="&apos;Liberation Serif&apos;" style:font-family-generic="swiss" style:font-pitch="variable"/>
+  <style:font-face style:name="FreeSans" svg:font-family="FreeSans" style:font-family-generic="system" style:font-pitch="variable"/>
   <style:font-face style:name="Noto Sans CJK SC" svg:font-family="&apos;Noto Sans CJK SC&apos;" style:font-family-generic="system" style:font-pitch="variable"/>
   <style:font-face style:name="Noto Serif CJK SC" svg:font-family="&apos;Noto Serif CJK SC&apos;" style:font-family-generic="system" style:font-pitch="variable"/>
-  <style:font-face style:name="OpenSymbol" svg:font-family="OpenSymbol"/>
+  <style:font-face style:name="OpenSymbol1" svg:font-family="OpenSymbol" style:font-family-generic="system" style:font-pitch="variable"/>
  </office:font-face-decls>
  <office:styles>
   <style:default-style style:family="graphic">
    <style:graphic-properties svg:stroke-color="#3465a4" draw:fill-color="#729fcf" fo:wrap-option="no-wrap" draw:shadow-offset-x="0.3cm" draw:shadow-offset-y="0.3cm" draw:start-line-spacing-horizontal="0.283cm" draw:start-line-spacing-vertical="0.283cm" draw:end-line-spacing-horizontal="0.283cm" draw:end-line-spacing-vertical="0.283cm" style:flow-with-text="false"/>
-   <style:paragraph-properties style:text-autospace="ideograph-alpha" style:line-break="strict" style:font-independent-line-spacing="false">
+   <style:paragraph-properties style:text-autospace="ideograph-alpha" style:line-break="strict" style:writing-mode="lr-tb" style:font-independent-line-spacing="false">
     <style:tab-stops/>
    </style:paragraph-properties>
    <style:text-properties style:use-window-font-color="true" loext:opacity="0%" style:font-name="Liberation Serif" fo:font-size="12pt" fo:language="fr" fo:country="FR" style:letter-kerning="true" style:font-name-asian="Noto Serif CJK SC" style:font-size-asian="10.5pt" style:language-asian="zh" style:country-asian="CN" style:font-name-complex="FreeSans" style:font-size-complex="12pt" style:language-complex="hi" style:country-complex="IN"/>
   </style:default-style>
   <style:default-style style:family="paragraph">
-   <style:paragraph-properties fo:orphans="2" fo:widows="2" fo:hyphenation-ladder-count="no-limit" style:text-autospace="ideograph-alpha" style:punctuation-wrap="hanging" style:line-break="strict" style:tab-stop-distance="1.251cm" style:writing-mode="page"/>
+   <style:paragraph-properties fo:orphans="2" fo:widows="2" fo:hyphenation-ladder-count="no-limit" style:text-autospace="ideograph-alpha" style:punctuation-wrap="hanging" style:line-break="strict" style:tab-stop-distance="1.251cm" style:writing-mode="lr-tb"/>
    <style:text-properties style:use-window-font-color="true" loext:opacity="0%" style:font-name="Liberation Serif" fo:font-size="12pt" fo:language="fr" fo:country="FR" style:letter-kerning="true" style:font-name-asian="Noto Serif CJK SC" style:font-size-asian="10.5pt" style:language-asian="zh" style:country-asian="CN" style:font-name-complex="FreeSans" style:font-size-complex="12pt" style:language-complex="hi" style:country-complex="IN" fo:hyphenate="false" fo:hyphenation-remain-char-count="2" fo:hyphenation-push-char-count="2" loext:hyphenation-no-caps="false"/>
   </style:default-style>
   <style:default-style style:family="table">
@@ -182,27 +179,27 @@
   <style:style style:name="Standard" style:family="paragraph" style:class="text">
    <style:paragraph-properties fo:margin-top="0.101cm" fo:margin-bottom="0.101cm" style:contextual-spacing="false" fo:text-align="justify" style:justify-single-word="false"/>
   </style:style>
-  <style:style style:name="Heading" style:family="paragraph" style:parent-style-name="_2d__3e__20_JRES" style:next-style-name="Text_20_body" style:class="text">
+  <style:style style:name="Heading" style:family="paragraph" style:parent-style-name="_2d__3e__20_JRES" style:default-outline-level="" style:class="text">
    <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
-   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="swiss" style:font-pitch="variable" fo:font-size="10pt" style:font-name-asian="Noto Sans CJK SC" style:font-family-asian="&apos;Noto Sans CJK SC&apos;" style:font-family-generic-asian="system" style:font-pitch-asian="variable" style:font-size-asian="10pt" style:font-name-complex="FreeSans" style:font-family-complex="FreeSans" style:font-family-generic-complex="system" style:font-pitch-complex="variable" style:font-size-complex="10pt"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="10pt" style:font-size-asian="10pt" style:font-size-complex="10pt"/>
   </style:style>
-  <style:style style:name="Text_20_body" style:display-name="Text body" style:family="paragraph" style:parent-style-name="Standard" style:class="text">
+  <style:style style:name="Text_20_body" style:display-name="Text body" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="text">
    <style:paragraph-properties fo:margin-top="0cm" fo:margin-bottom="0.247cm" style:contextual-spacing="false" fo:line-height="115%"/>
   </style:style>
-  <style:style style:name="List" style:family="paragraph" style:parent-style-name="Text_20_body" style:class="list">
-   <style:text-properties style:font-size-asian="12pt" style:font-name-complex="FreeSans1" style:font-family-complex="FreeSans" style:font-family-generic-complex="swiss"/>
+  <style:style style:name="List" style:family="paragraph" style:default-outline-level="" style:class="list">
+   <style:paragraph-properties fo:margin-top="0cm" fo:margin-bottom="0.247cm" style:contextual-spacing="false" fo:line-height="115%"/>
   </style:style>
-  <style:style style:name="Caption" style:family="paragraph" style:parent-style-name="Standard" style:class="extra">
-   <style:paragraph-properties fo:margin-top="0.212cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" text:number-lines="false" text:line-number="0"/>
-   <style:text-properties fo:font-size="12pt" fo:font-style="italic" style:font-size-asian="12pt" style:font-style-asian="italic" style:font-name-complex="FreeSans1" style:font-family-complex="FreeSans" style:font-family-generic-complex="swiss" style:font-size-complex="12pt" style:font-style-complex="italic"/>
+  <style:style style:name="Caption" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="extra">
+   <style:paragraph-properties fo:margin-top="0.212cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false"/>
+   <style:text-properties fo:font-style="italic" style:font-style-asian="italic" style:font-style-complex="italic"/>
   </style:style>
   <style:style style:name="Index" style:family="paragraph" style:parent-style-name="Standard" style:class="index">
    <style:paragraph-properties text:number-lines="false" text:line-number="0"/>
    <style:text-properties style:font-size-asian="12pt" style:font-name-complex="FreeSans1" style:font-family-complex="FreeSans" style:font-family-generic-complex="swiss"/>
   </style:style>
-  <style:style style:name="Title" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Text_20_body" style:class="chapter">
-   <style:paragraph-properties fo:text-align="center" style:justify-single-word="false"/>
-   <style:text-properties fo:font-size="20pt" fo:font-weight="bold" style:font-size-asian="20pt" style:font-weight-asian="bold" style:font-size-complex="20pt" style:font-weight-complex="600"/>
+  <style:style style:name="Title" style:family="paragraph" style:default-outline-level="" style:class="chapter">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:text-align="center" style:justify-single-word="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="20pt" fo:font-weight="bold" style:font-size-asian="20pt" style:font-weight-asian="bold" style:font-size-complex="20pt" style:font-weight-complex="normal"/>
   </style:style>
   <style:style style:name="Auteurs" style:family="paragraph" style:parent-style-name="Heading">
    <style:paragraph-properties fo:margin-top="0.3cm" fo:margin-bottom="0cm" style:contextual-spacing="false"/>
@@ -226,13 +223,13 @@
   <style:style style:name="Mots-clefs" style:family="paragraph" style:parent-style-name="Résumé">
    <style:text-properties fo:font-size="12pt"/>
   </style:style>
-  <style:style style:name="Heading_20_1" style:display-name="Heading 1" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Text_20_body" style:default-outline-level="1" style:class="text">
-   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false"/>
-   <style:text-properties fo:font-size="140%" fo:font-weight="bold" style:font-size-asian="140%" style:font-weight-asian="bold" style:font-size-complex="140%" style:font-weight-complex="600"/>
+  <style:style style:name="Heading_20_1" style:display-name="Heading 1" style:family="paragraph" style:default-outline-level="1" style:list-style-name="" style:class="text">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="14pt" fo:font-weight="bold" style:font-size-asian="14pt" style:font-weight-asian="bold" style:font-size-complex="14pt" style:font-weight-complex="normal"/>
   </style:style>
-  <style:style style:name="Heading_20_2" style:display-name="Heading 2" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Text_20_body" style:default-outline-level="2" style:class="text">
-   <style:paragraph-properties fo:margin-top="0.353cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false"/>
-   <style:text-properties fo:font-size="120%" fo:font-weight="bold" style:font-size-asian="115%" style:font-weight-asian="bold" style:font-size-complex="115%" style:font-weight-complex="bold"/>
+  <style:style style:name="Heading_20_2" style:display-name="Heading 2" style:family="paragraph" style:default-outline-level="2" style:list-style-name="" style:class="text">
+   <style:paragraph-properties fo:margin-top="0.353cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="12pt" fo:font-weight="bold" style:font-size-asian="12pt" style:font-weight-asian="bold" style:font-size-complex="11.5pt" style:font-weight-complex="bold"/>
   </style:style>
   <style:style style:name="code_20_source" style:display-name="code source" style:family="paragraph" style:parent-style-name="_2d__3e__20_JRES" style:master-page-name="">
    <loext:graphic-properties draw:fill="solid" draw:fill-color="#eeeeee"/>
@@ -241,53 +238,54 @@
    </style:paragraph-properties>
    <style:text-properties style:font-name="Liberation Mono" fo:font-family="&apos;Liberation Mono&apos;" style:font-style-name="Normal" style:font-family-generic="modern" style:font-pitch="fixed" fo:font-size="8pt" style:font-name-asian="Courier New" style:font-family-asian="&apos;Courier New&apos;" style:font-family-generic-asian="modern" style:font-pitch-asian="fixed" style:font-name-complex="Courier New" style:font-family-complex="&apos;Courier New&apos;" style:font-family-generic-complex="modern" style:font-pitch-complex="fixed"/>
   </style:style>
-  <style:style style:name="Heading_20_3" style:display-name="Heading 3" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Text_20_body" style:default-outline-level="3" style:class="text">
-   <style:paragraph-properties fo:margin-top="0.247cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false"/>
-   <style:text-properties fo:font-size="10pt" fo:font-weight="bold" style:font-size-asian="101%" style:font-weight-asian="bold" style:font-size-complex="101%" style:font-weight-complex="600"/>
+  <style:style style:name="Heading_20_3" style:display-name="Heading 3" style:family="paragraph" style:default-outline-level="3" style:list-style-name="" style:class="text">
+   <style:paragraph-properties fo:margin-top="0.247cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="10pt" fo:font-weight="bold" style:font-size-asian="10pt" style:font-weight-asian="bold" style:font-size-complex="10pt" style:font-weight-complex="normal"/>
   </style:style>
-  <style:style style:name="Footnote" style:family="paragraph" style:parent-style-name="Standard" style:class="extra">
-   <style:paragraph-properties fo:margin-left="0.598cm" fo:margin-right="0cm" fo:text-indent="-0.598cm" style:auto-text-indent="false" text:number-lines="false" text:line-number="0"/>
-   <style:text-properties fo:font-size="8pt" style:font-size-asian="10pt" style:font-size-complex="10pt"/>
+  <style:style style:name="Footnote" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="extra">
+   <style:paragraph-properties fo:margin-left="0.598cm" fo:margin-right="0cm" fo:text-indent="-0.598cm" style:auto-text-indent="false"/>
+   <style:text-properties fo:font-size="8pt" style:font-size-asian="8pt"/>
   </style:style>
   <style:style style:name="Appendix" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Text_20_body" style:class="chapter">
    <style:paragraph-properties fo:text-align="start" style:justify-single-word="false"/>
    <style:text-properties fo:font-size="14pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="600"/>
   </style:style>
-  <style:style style:name="Subtitle" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Text_20_body" style:class="chapter">
-   <style:paragraph-properties fo:margin-top="0.106cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:text-align="center" style:justify-single-word="false"/>
-   <style:text-properties fo:font-size="18pt" style:font-size-asian="18pt" style:font-size-complex="18pt"/>
+  <style:style style:name="Subtitle" style:family="paragraph" style:default-outline-level="" style:class="chapter">
+   <style:paragraph-properties fo:margin-top="0.106cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:text-align="center" style:justify-single-word="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="18pt" style:font-size-asian="18pt" style:font-size-complex="18pt"/>
   </style:style>
-  <style:style style:name="Endnote" style:family="paragraph" style:parent-style-name="Standard" style:class="extra"/>
-  <style:style style:name="Index_20_Heading" style:display-name="Index Heading" style:family="paragraph" style:parent-style-name="Heading" style:class="index">
-   <style:paragraph-properties fo:margin-left="0cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false" text:number-lines="false" text:line-number="0"/>
-   <style:text-properties fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
+  <style:style style:name="Endnote" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="extra"/>
+  <style:style style:name="Index_20_Heading" style:display-name="Index Heading" style:family="paragraph" style:default-outline-level="" style:class="index">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
   </style:style>
-  <style:style style:name="Table_20_index_20_heading" style:display-name="Table index heading" style:family="paragraph" style:parent-style-name="Heading" style:class="index">
-   <style:paragraph-properties fo:margin-left="0cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false" text:number-lines="false" text:line-number="0"/>
-   <style:text-properties fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
+  <style:style style:name="Table_20_index_20_heading" style:display-name="Table index heading" style:family="paragraph" style:default-outline-level="" style:class="index">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
   </style:style>
-  <style:style style:name="User_20_Index_20_Heading" style:display-name="User Index Heading" style:family="paragraph" style:parent-style-name="Heading" style:class="index">
-   <style:paragraph-properties fo:margin-left="0cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false" text:number-lines="false" text:line-number="0"/>
-   <style:text-properties fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
+  <style:style style:name="User_20_Index_20_Heading" style:display-name="User Index Heading" style:family="paragraph" style:default-outline-level="" style:class="index">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
   </style:style>
   <style:style style:name="Illustration_20_Index_20_Heading" style:display-name="Illustration Index Heading" style:family="paragraph" style:parent-style-name="Heading" style:class="index">
    <style:paragraph-properties fo:margin-left="0cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false" text:number-lines="false" text:line-number="0"/>
    <style:text-properties fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
   </style:style>
-  <style:style style:name="Contents_20_Heading" style:display-name="Contents Heading" style:family="paragraph" style:parent-style-name="Heading" style:class="index">
-   <style:paragraph-properties fo:margin-left="0cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false" text:number-lines="false" text:line-number="0"/>
-   <style:text-properties fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
+  <style:style style:name="Contents_20_Heading" style:display-name="Contents Heading" style:family="paragraph" style:default-outline-level="" style:class="index">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
   </style:style>
-  <style:style style:name="Bibliography_20_Heading" style:display-name="Bibliography Heading" style:family="paragraph" style:parent-style-name="Heading" style:class="index">
-   <style:paragraph-properties fo:margin-left="0cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false" text:number-lines="false" text:line-number="0"/>
-   <style:text-properties fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
+  <style:style style:name="Bibliography_20_Heading" style:display-name="Bibliography Heading" style:family="paragraph" style:default-outline-level="" style:class="index">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="16pt" fo:font-weight="bold" style:font-size-asian="16pt" style:font-weight-asian="bold" style:font-size-complex="16pt" style:font-weight-complex="bold"/>
   </style:style>
-  <style:style style:name="Heading_20_5" style:display-name="Heading 5" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Text_20_body" style:default-outline-level="5" style:list-style-name="" style:class="text">
-   <style:text-properties fo:font-size="85%" fo:font-weight="bold" style:font-size-asian="85%" style:font-weight-asian="bold" style:font-size-complex="85%" style:font-weight-complex="bold"/>
+  <style:style style:name="Heading_20_5" style:display-name="Heading 5" style:family="paragraph" style:default-outline-level="" style:list-style-name="" style:class="text">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Liberation Sans1" fo:font-family="&apos;Liberation Sans&apos;" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="8.5pt" fo:font-weight="bold" style:font-size-asian="8.5pt" style:font-weight-asian="bold" style:font-size-complex="8.5pt" style:font-weight-complex="bold"/>
   </style:style>
-  <style:style style:name="Heading_20_4" style:display-name="Heading 4" style:family="paragraph" style:parent-style-name="Heading" style:next-style-name="Standard" style:default-outline-level="4" style:list-style-name="" style:class="text">
-   <style:paragraph-properties fo:text-align="start" style:justify-single-word="false"/>
-   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Arial" fo:font-family="Arial" style:font-style-name="Gras Italique" style:font-family-generic="swiss" style:font-pitch="variable" fo:font-size="10pt" fo:font-style="italic" fo:font-weight="bold" style:font-size-asian="85%" style:font-style-asian="italic" style:font-weight-asian="bold" style:font-size-complex="85%" style:font-style-complex="italic" style:font-weight-complex="bold"/>
+  <style:style style:name="Heading_20_4" style:display-name="Heading 4" style:family="paragraph" style:default-outline-level="" style:list-style-name="" style:class="text">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:text-align="start" style:justify-single-word="false" fo:keep-with-next="always"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" style:font-name="Arial" fo:font-family="Arial" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="10pt" fo:font-style="italic" fo:font-weight="bold" style:font-size-asian="10pt" style:font-style-asian="italic" style:font-weight-asian="bold" style:font-size-complex="8.5pt" style:font-style-complex="italic" style:font-weight-complex="bold"/>
   </style:style>
   <style:style style:name="Figure_20_-_20_Légende" style:display-name="Figure - Légende" style:family="paragraph" style:parent-style-name="Standard" style:next-style-name="Standard" style:list-style-name="Figure" style:class="text">
    <style:paragraph-properties fo:text-align="center" style:justify-single-word="false"/>
@@ -300,8 +298,8 @@
    <style:paragraph-properties fo:margin-top="0.45cm" fo:margin-bottom="0.3cm" style:contextual-spacing="false"/>
    <style:text-properties officeooo:rsid="0011cbff"/>
   </style:style>
-  <style:style style:name="Numbering_20_4" style:display-name="Numbering 4" style:family="paragraph" style:parent-style-name="List" style:class="list">
-   <style:paragraph-properties fo:margin-left="2.54cm" fo:margin-right="0cm" fo:margin-top="0cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:text-indent="-0.635cm" style:auto-text-indent="false"/>
+  <style:style style:name="Numbering_20_4" style:display-name="Numbering 4" style:family="paragraph" style:default-outline-level="" style:class="list">
+   <style:paragraph-properties fo:margin-left="2.54cm" fo:margin-right="0cm" fo:margin-top="0cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:line-height="115%" fo:text-indent="-0.635cm" style:auto-text-indent="false"/>
   </style:style>
   <style:style style:name="Bibliographie_20_-_20_Liste_20_de_20_références" style:display-name="Bibliographie - Liste de références" style:family="paragraph" style:parent-style-name="Standard" style:list-style-name="Numbering_20_4"/>
   <style:style style:name="List_20_1" style:display-name="List 1" style:family="paragraph" style:parent-style-name="List" style:list-style-name="List_20_2" style:class="list" style:master-page-name="">
@@ -317,8 +315,8 @@
     </style:tab-stops>
    </style:paragraph-properties>
   </style:style>
-  <style:style style:name="Header" style:family="paragraph" style:parent-style-name="Standard" style:class="extra">
-   <style:paragraph-properties text:number-lines="false" text:line-number="0">
+  <style:style style:name="Header" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="extra">
+   <style:paragraph-properties>
     <style:tab-stops>
      <style:tab-stop style:position="8.5cm" style:type="center"/>
      <style:tab-stop style:position="17cm" style:type="right"/>
@@ -329,29 +327,29 @@
    <style:paragraph-properties fo:margin-top="0.45cm" fo:margin-bottom="0cm" style:contextual-spacing="false"/>
    <style:text-properties officeooo:rsid="00070bde"/>
   </style:style>
-  <style:style style:name="Footer" style:family="paragraph" style:parent-style-name="_2d__3e__20_JRES" style:class="extra">
-   <style:paragraph-properties fo:padding="0.049cm" fo:border-left="none" fo:border-right="none" fo:border-top="0.06pt solid #000000" fo:border-bottom="none" style:shadow="none" text:number-lines="false" text:line-number="0">
+  <style:style style:name="Footer" style:family="paragraph" style:default-outline-level="" style:class="extra">
+   <style:paragraph-properties fo:padding-left="0cm" fo:padding-right="0cm" fo:padding-top="0.035cm" fo:padding-bottom="0cm" fo:border-left="none" fo:border-right="none" fo:border-top="0.11pt solid #000000" fo:border-bottom="none">
     <style:tab-stops>
      <style:tab-stop style:position="8.5cm" style:type="center"/>
      <style:tab-stop style:position="17cm" style:type="right"/>
     </style:tab-stops>
    </style:paragraph-properties>
-   <style:text-properties fo:color="#808080" loext:opacity="100%" fo:font-style="italic" style:font-size-asian="10.5pt" style:font-weight-asian="normal"/>
+   <style:text-properties fo:color="#808080" loext:opacity="100%" fo:font-style="italic" style:font-style-asian="italic"/>
   </style:style>
-  <style:style style:name="Bibliography_20_1" style:display-name="Bibliography 1" style:family="paragraph" style:parent-style-name="Index" style:class="index">
-   <style:paragraph-properties fo:margin-left="0cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false">
+  <style:style style:name="Bibliography_20_1" style:display-name="Bibliography 1" style:family="paragraph" style:default-outline-level="" style:class="index">
+   <style:paragraph-properties>
     <style:tab-stops>
      <style:tab-stop style:position="17cm" style:type="right" style:leader-style="dotted" style:leader-text="."/>
     </style:tab-stops>
    </style:paragraph-properties>
   </style:style>
-  <style:style style:name="List_20_Contents" style:display-name="List Contents" style:family="paragraph" style:parent-style-name="Standard" style:class="html">
+  <style:style style:name="List_20_Contents" style:display-name="List Contents" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="html">
    <style:paragraph-properties fo:margin-left="1cm" fo:margin-right="0cm" fo:text-indent="0cm" style:auto-text-indent="false"/>
   </style:style>
   <style:style style:name="Figure" style:family="paragraph" style:parent-style-name="Caption" style:class="extra">
    <style:paragraph-properties fo:text-align="center" style:justify-single-word="false"/>
   </style:style>
-  <style:style style:name="Frame_20_contents" style:display-name="Frame contents" style:family="paragraph" style:parent-style-name="Standard" style:class="extra"/>
+  <style:style style:name="Frame_20_contents" style:display-name="Frame contents" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="extra"/>
   <style:style style:name="List_20_1_20_Start" style:display-name="List 1 Start" style:family="paragraph" style:parent-style-name="List" style:next-style-name="List_20_1" style:list-style-name="List_20_2" style:class="list">
    <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false"/>
   </style:style>
@@ -364,9 +362,24 @@
   <style:style style:name="List_20_2_20_Start" style:display-name="List 2 Start" style:family="paragraph" style:parent-style-name="List" style:next-style-name="List_20_2" style:class="list">
    <style:paragraph-properties fo:margin-left="1.27cm" fo:margin-right="0cm" fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:text-indent="-0.635cm" style:auto-text-indent="false"/>
   </style:style>
-  <style:style style:name="Quotations" style:family="paragraph" style:parent-style-name="Standard" style:class="html">
+  <style:style style:name="Quotations" style:family="paragraph" style:parent-style-name="Standard" style:default-outline-level="" style:class="html">
    <style:paragraph-properties fo:margin-left="1cm" fo:margin-right="1cm" fo:margin-top="0.101cm" fo:margin-bottom="0.499cm" style:contextual-spacing="false" fo:text-indent="0cm" style:auto-text-indent="false"/>
   </style:style>
+  <style:style style:name="Puce_20_2_20_début" style:display-name="Puce 2 début" style:family="paragraph" style:default-outline-level="">
+   <style:paragraph-properties fo:margin-left="1.27cm" fo:margin-right="0cm" fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:line-height="115%" fo:text-indent="-0.635cm" style:auto-text-indent="false"/>
+  </style:style>
+  <style:style style:name="Puce_20_2" style:display-name="Puce 2" style:family="paragraph" style:default-outline-level="">
+   <style:paragraph-properties fo:margin-left="1.27cm" fo:margin-right="0cm" fo:margin-top="0cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:line-height="115%" fo:text-indent="-0.635cm" style:auto-text-indent="false"/>
+  </style:style>
+  <style:style style:name="Puce_20_1_20_fin" style:display-name="Puce 1 fin" style:family="paragraph" style:default-outline-level="">
+   <style:paragraph-properties fo:margin-left="0.635cm" fo:margin-right="0cm" fo:margin-top="0cm" fo:margin-bottom="0.423cm" style:contextual-spacing="false" fo:line-height="115%" fo:text-indent="-0.635cm" style:auto-text-indent="false"/>
+  </style:style>
+  <style:style style:name="Puce_20_1_20_début" style:display-name="Puce 1 début" style:family="paragraph" style:default-outline-level="">
+   <style:paragraph-properties fo:margin-top="0.423cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:line-height="115%"/>
+  </style:style>
+  <style:style style:name="Puce_20_1" style:display-name="Puce 1" style:family="paragraph" style:default-outline-level="">
+   <style:paragraph-properties fo:margin-top="0cm" fo:margin-bottom="0.212cm" style:contextual-spacing="false" fo:line-height="115%"/>
+  </style:style>
   <style:style style:name="Footnote_20_Symbol" style:display-name="Footnote Symbol" style:family="text"/>
   <style:style style:name="Footnote_20_anchor" style:display-name="Footnote anchor" style:family="text">
    <style:text-properties style:text-position="super 58%"/>
@@ -376,20 +389,20 @@
   </style:style>
   <style:style style:name="Endnote_20_Symbol" style:display-name="Endnote Symbol" style:family="text"/>
   <style:style style:name="Visited_20_Internet_20_Link" style:display-name="Visited Internet Link" style:family="text">
-   <style:text-properties fo:color="#00335f" loext:opacity="100%" fo:language="zxx" fo:country="none" style:text-underline-style="none" style:language-asian="zxx" style:country-asian="none" style:language-complex="zxx" style:country-complex="none"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" fo:language="zxx" fo:country="none" style:text-underline-style="none" style:language-asian="zxx" style:country-asian="none"/>
   </style:style>
   <style:style style:name="Bullet_20_Symbols" style:display-name="Bullet Symbols" style:family="text">
-   <style:text-properties style:font-name="OpenSymbol" fo:font-family="OpenSymbol" fo:font-size="6pt" style:font-name-asian="OpenSymbol" style:font-family-asian="OpenSymbol" style:font-size-asian="5.25pt" style:font-name-complex="OpenSymbol" style:font-family-complex="OpenSymbol" style:font-size-complex="6pt"/>
+   <style:text-properties style:font-name="OpenSymbol" fo:font-family="OpenSymbol" style:font-family-generic="roman" style:font-pitch="variable" fo:font-size="6pt" style:font-name-asian="OpenSymbol1" style:font-family-asian="OpenSymbol" style:font-family-generic-asian="system" style:font-pitch-asian="variable" style:font-size-asian="6pt" style:font-size-complex="6pt"/>
   </style:style>
   <style:style style:name="Internet_20_link" style:display-name="Internet link" style:family="text">
-   <style:text-properties fo:color="#00335f" loext:opacity="100%" fo:language="zxx" fo:country="none" style:text-underline-style="none" style:font-size-asian="10.5pt" style:language-asian="zxx" style:country-asian="none" style:language-complex="zxx" style:country-complex="none"/>
+   <style:text-properties fo:color="#00335f" loext:opacity="100%" fo:language="zxx" fo:country="none" style:text-underline-style="none" style:language-asian="zxx" style:country-asian="none"/>
   </style:style>
   <style:style style:name="Numbering_20_Symbols" style:display-name="Numbering Symbols" style:family="text"/>
   <style:style style:name="Strong_20_Emphasis" style:display-name="Strong Emphasis" style:family="text">
-   <style:text-properties fo:font-weight="bold" style:font-weight-asian="bold" style:font-weight-complex="bold"/>
+   <style:text-properties fo:font-weight="bold" style:font-weight-asian="bold"/>
   </style:style>
   <style:style style:name="Emphasis" style:family="text">
-   <style:text-properties fo:font-style="italic" style:font-style-asian="italic" style:font-style-complex="italic"/>
+   <style:text-properties fo:font-style="italic" style:font-style-asian="italic"/>
   </style:style>
   <style:style style:name="Graphics" style:family="graphic">
    <style:graphic-properties text:anchor-type="paragraph" svg:x="0cm" svg:y="0cm" style:wrap="none" style:vertical-pos="top" style:vertical-rel="paragraph" style:horizontal-pos="center" style:horizontal-rel="paragraph"/>
@@ -398,113 +411,113 @@
    <style:graphic-properties text:anchor-type="paragraph" svg:x="0cm" svg:y="0cm" fo:margin-left="0.201cm" fo:margin-right="0.201cm" fo:margin-top="0.201cm" fo:margin-bottom="0.201cm" style:wrap="parallel" style:number-wrapped-paragraphs="no-limit" style:wrap-contour="false" style:vertical-pos="top" style:vertical-rel="paragraph-content" style:horizontal-pos="center" style:horizontal-rel="paragraph-content" fo:padding="0.15cm" fo:border="0.06pt solid #000000"/>
   </style:style>
   <text:outline-style style:name="Outline">
-   <text:outline-level-style text:level="1" loext:num-list-format="%1%" style:num-format="1">
+   <text:outline-level-style text:level="1" style:num-format="1">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="2" loext:num-list-format="%1%.%2%" style:num-format="1" text:display-levels="2">
+   <text:outline-level-style text:level="2" style:num-format="1" text:display-levels="2">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="3" loext:num-list-format="%1%.%2%.%3%" style:num-format="1" text:display-levels="3">
+   <text:outline-level-style text:level="3" style:num-format="1" text:display-levels="3">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="4" loext:num-list-format="%4%" style:num-format="">
+   <text:outline-level-style text:level="4" style:num-format="">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="5" loext:num-list-format="%5%" style:num-format="">
+   <text:outline-level-style text:level="5" style:num-format="">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="6" loext:num-list-format="%6%" style:num-format="">
+   <text:outline-level-style text:level="6" style:num-format="">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="7" loext:num-list-format="%7%" style:num-format="">
+   <text:outline-level-style text:level="7" style:num-format="">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="8" loext:num-list-format="%8%" style:num-format="">
+   <text:outline-level-style text:level="8" style:num-format="">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="9" loext:num-list-format="%9%" style:num-format="">
+   <text:outline-level-style text:level="9" style:num-format="">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
-   <text:outline-level-style text:level="10" loext:num-list-format="%10%" style:num-format="">
+   <text:outline-level-style text:level="10" style:num-format="">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab"/>
     </style:list-level-properties>
    </text:outline-level-style>
   </text:outline-style>
   <text:list-style style:name="List_20_1" style:display-name="List 1">
-   <text:list-level-style-bullet text:level="1" text:style-name="Bullet_20_Symbols" loext:num-list-format="%1%" text:bullet-char="―">
+   <text:list-level-style-bullet text:level="1" text:style-name="Bullet_20_Symbols" text:bullet-char="―">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="space" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="&apos;Liberation Serif&apos;" style:font-style-name="Regular" style:font-family-generic="roman"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="2" text:style-name="Bullet_20_Symbols" loext:num-list-format="%2%" text:bullet-char="―">
+   <text:list-level-style-bullet text:level="2" text:style-name="Bullet_20_Symbols" text:bullet-char="―">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="space" fo:text-indent="0.051cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="&apos;Liberation Serif&apos;" style:font-style-name="Regular" style:font-family-generic="roman"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="3" text:style-name="Bullet_20_Symbols" loext:num-list-format="%3%" text:bullet-char="―">
+   <text:list-level-style-bullet text:level="3" text:style-name="Bullet_20_Symbols" text:bullet-char="―">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="space" fo:text-indent="0.351cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="&apos;Liberation Serif&apos;" style:font-style-name="Regular" style:font-family-generic="roman"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="4" text:style-name="Bullet_20_Symbols" loext:num-list-format="%4%" text:bullet-char="―">
+   <text:list-level-style-bullet text:level="4" text:style-name="Bullet_20_Symbols" text:bullet-char="―">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="1.6cm" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="Ubuntu" style:font-style-name="Regular"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="5" text:style-name="Bullet_20_Symbols" loext:num-list-format="%5%" text:bullet-char="◾">
+   <text:list-level-style-bullet text:level="5" text:style-name="Bullet_20_Symbols" text:bullet-char="◾">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="2cm" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="Cantarell" style:font-style-name="Regular"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="6" text:style-name="Bullet_20_Symbols" loext:num-list-format="%6%" text:bullet-char="◾">
+   <text:list-level-style-bullet text:level="6" text:style-name="Bullet_20_Symbols" text:bullet-char="◾">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="2.401cm" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="Cantarell" style:font-style-name="Regular"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="7" text:style-name="Bullet_20_Symbols" loext:num-list-format="%7%" text:bullet-char="◾">
+   <text:list-level-style-bullet text:level="7" text:style-name="Bullet_20_Symbols" text:bullet-char="◾">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="2.799cm" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="Cantarell" style:font-style-name="Regular"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="8" text:style-name="Bullet_20_Symbols" loext:num-list-format="%8%" text:bullet-char="◾">
+   <text:list-level-style-bullet text:level="8" text:style-name="Bullet_20_Symbols" text:bullet-char="◾">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="3.2cm" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="Cantarell" style:font-style-name="Regular"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="9" text:style-name="Bullet_20_Symbols" loext:num-list-format="%9%" text:bullet-char="◾">
+   <text:list-level-style-bullet text:level="9" text:style-name="Bullet_20_Symbols" text:bullet-char="◾">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="3.6cm" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="Cantarell" style:font-style-name="Regular"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="10" text:style-name="Bullet_20_Symbols" loext:num-list-format="%10%" text:bullet-char="◾">
+   <text:list-level-style-bullet text:level="10" text:style-name="Bullet_20_Symbols" text:bullet-char="◾">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="4.001cm" fo:text-indent="-0.349cm" fo:margin-left="1.05cm"/>
     </style:list-level-properties>
@@ -512,61 +525,61 @@
    </text:list-level-style-bullet>
   </text:list-style>
   <text:list-style style:name="List_20_2" style:display-name="List 2">
-   <text:list-level-style-bullet text:level="1" text:style-name="Bullet_20_Symbols" loext:num-list-format="%1%" text:bullet-char="—">
+   <text:list-level-style-bullet text:level="1" text:style-name="Bullet_20_Symbols" text:bullet-char="—">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="space" fo:text-indent="0.3cm" fo:margin-left="0.3cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="OpenSymbol" style:font-style-name="Regular" style:font-charset="x-symbol"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="2" text:style-name="Bullet_20_Symbols" loext:num-list-format="%2%" text:bullet-char="—">
+   <text:list-level-style-bullet text:level="2" text:style-name="Bullet_20_Symbols" text:bullet-char="—">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="space" fo:text-indent="0.6cm" fo:margin-left="0.6cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="OpenSymbol" style:font-style-name="Regular" style:font-charset="x-symbol"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="3" text:style-name="Bullet_20_Symbols" loext:num-list-format="%3%" text:bullet-char="—">
+   <text:list-level-style-bullet text:level="3" text:style-name="Bullet_20_Symbols" text:bullet-char="—">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="space" fo:text-indent="0.9cm" fo:margin-left="0.9cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="OpenSymbol" style:font-style-name="Regular" style:font-charset="x-symbol"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="4" text:style-name="Bullet_20_Symbols" loext:num-list-format="%4%" text:bullet-char="➔">
+   <text:list-level-style-bullet text:level="4" text:style-name="Bullet_20_Symbols" text:bullet-char="➔">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="1.199cm" fo:text-indent="-0.3cm" fo:margin-left="1.199cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="5" text:style-name="Bullet_20_Symbols" loext:num-list-format="%5%" text:bullet-char="➔">
+   <text:list-level-style-bullet text:level="5" text:style-name="Bullet_20_Symbols" text:bullet-char="➔">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="1.499cm" fo:text-indent="-0.3cm" fo:margin-left="1.499cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="6" text:style-name="Bullet_20_Symbols" loext:num-list-format="%6%" text:bullet-char="➔">
+   <text:list-level-style-bullet text:level="6" text:style-name="Bullet_20_Symbols" text:bullet-char="➔">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
      <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="1.799cm" fo:text-indent="-0.3cm" fo:margin-left="1.799cm"/>
     </style:list-level-properties>
     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
    </text:list-level-style-bullet>
-   <text:list-level-style-bullet text:level="7" text:style-name="Bullet_20_Symbols" loext:num-list-format="%7%" text:bullet-char="➔">
+   <text:list-level-style-bullet text:level="7" text:style-name="Bullet_20_Symbols" text:bullet-char="➔">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
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     </style:list-level-properties>
     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
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-   <text:list-level-style-bullet text:level="8" text:style-name="Bullet_20_Symbols" loext:num-list-format="%8%" text:bullet-char="➔">
+   <text:list-level-style-bullet text:level="8" text:style-name="Bullet_20_Symbols" text:bullet-char="➔">
     <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
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     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
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-   <text:list-level-style-bullet text:level="9" text:style-name="Bullet_20_Symbols" loext:num-list-format="%9%" text:bullet-char="➔">
+   <text:list-level-style-bullet text:level="9" text:style-name="Bullet_20_Symbols" text:bullet-char="➔">
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     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
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-   <text:list-level-style-bullet text:level="10" text:style-name="Bullet_20_Symbols" loext:num-list-format="%10%" text:bullet-char="➔">
+   <text:list-level-style-bullet text:level="10" text:style-name="Bullet_20_Symbols" text:bullet-char="➔">
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@@ -574,123 +587,123 @@
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-   <text:list-level-style-bullet text:level="1" text:style-name="Numbering_20_Symbols" loext:num-list-format="%1%" text:bullet-char="☑">
+   <text:list-level-style-bullet text:level="1" text:style-name="Numbering_20_Symbols" text:bullet-char="☑">
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-    <style:text-properties style:font-name="OpenSymbol"/>
+    <style:text-properties fo:font-family="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="2" text:style-name="Numbering_20_Symbols" loext:num-list-format="%2%" text:bullet-char="□">
+   <text:list-level-style-bullet text:level="2" text:style-name="Numbering_20_Symbols" text:bullet-char="□">
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-    <style:text-properties style:font-name="OpenSymbol"/>
+    <style:text-properties fo:font-family="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="3" text:style-name="Numbering_20_Symbols" loext:num-list-format="%3%" text:bullet-char="☑">
+   <text:list-level-style-bullet text:level="3" text:style-name="Numbering_20_Symbols" text:bullet-char="☑">
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-    <style:text-properties style:font-name="OpenSymbol"/>
+    <style:text-properties fo:font-family="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="4" text:style-name="Numbering_20_Symbols" loext:num-list-format="%4%" text:bullet-char="□">
+   <text:list-level-style-bullet text:level="4" text:style-name="Numbering_20_Symbols" text:bullet-char="□">
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-    <style:text-properties style:font-name="OpenSymbol"/>
+    <style:text-properties fo:font-family="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="5" text:style-name="Numbering_20_Symbols" loext:num-list-format="%5%" text:bullet-char="☑">
+   <text:list-level-style-bullet text:level="5" text:style-name="Numbering_20_Symbols" text:bullet-char="☑">
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-    <style:text-properties style:font-name="OpenSymbol"/>
+    <style:text-properties fo:font-family="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="6" text:style-name="Numbering_20_Symbols" loext:num-list-format="%6%" text:bullet-char="□">
+   <text:list-level-style-bullet text:level="6" text:style-name="Numbering_20_Symbols" text:bullet-char="□">
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-    <style:text-properties style:font-name="OpenSymbol"/>
+    <style:text-properties fo:font-family="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="7" text:style-name="Numbering_20_Symbols" loext:num-list-format="%7%" text:bullet-char="☑">
+   <text:list-level-style-bullet text:level="7" text:style-name="Numbering_20_Symbols" text:bullet-char="☑">
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+    <style:text-properties fo:font-family="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="8" text:style-name="Numbering_20_Symbols" loext:num-list-format="%8%" text:bullet-char="□">
+   <text:list-level-style-bullet text:level="8" text:style-name="Numbering_20_Symbols" text:bullet-char="□">
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-    <style:text-properties style:font-name="OpenSymbol"/>
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-   <text:list-level-style-bullet text:level="9" text:style-name="Numbering_20_Symbols" loext:num-list-format="%9%" text:bullet-char="☑">
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+    <style:text-properties fo:font-family="OpenSymbol"/>
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+    <style:text-properties fo:font-family="OpenSymbol"/>
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   <text:list-style style:name="List_20_4" style:display-name="List 4">
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+   <text:list-level-style-bullet text:level="1" text:style-name="Numbering_20_Symbols" text:bullet-char="➢">
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     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
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+   <text:list-level-style-bullet text:level="4" text:style-name="Numbering_20_Symbols" text:bullet-char="">
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+   <text:list-level-style-bullet text:level="7" text:style-name="Numbering_20_Symbols" text:bullet-char="">
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     <style:text-properties fo:font-family="OpenSymbol" style:font-charset="x-symbol"/>
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-   <text:list-level-style-bullet text:level="8" text:style-name="Numbering_20_Symbols" loext:num-list-format="%8%" text:bullet-char="">
+   <text:list-level-style-bullet text:level="8" text:style-name="Numbering_20_Symbols" text:bullet-char="">
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-   <text:list-level-style-bullet text:level="9" text:style-name="Numbering_20_Symbols" loext:num-list-format="%9%" text:bullet-char="">
+   <text:list-level-style-bullet text:level="9" text:style-name="Numbering_20_Symbols" text:bullet-char="">
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-   <text:list-level-style-bullet text:level="10" text:style-name="Numbering_20_Symbols" loext:num-list-format="%10%" text:bullet-char="">
+   <text:list-level-style-bullet text:level="10" text:style-name="Numbering_20_Symbols" text:bullet-char="">
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@@ -698,61 +711,61 @@
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   <text:list-style style:name="List_20_5" style:display-name="List 5">
-   <text:list-level-style-bullet text:level="1" text:style-name="Numbering_20_Symbols" loext:num-list-format="%1%" text:bullet-char="✗">
+   <text:list-level-style-bullet text:level="1" text:style-name="Numbering_20_Symbols" text:bullet-char="✗">
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+   <text:list-level-style-bullet text:level="4" text:style-name="Numbering_20_Symbols" text:bullet-char="✗">
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+   <text:list-level-style-bullet text:level="5" text:style-name="Numbering_20_Symbols" text:bullet-char="✗">
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+   <text:list-level-style-bullet text:level="8" text:style-name="Numbering_20_Symbols" text:bullet-char="✗">
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+    </style:list-level-properties>
+   </text:list-level-style-number>
+   <text:list-level-style-number text:level="4" style:num-format="">
+    <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
+     <style:list-level-label-alignment text:label-followed-by="nothing"/>
+    </style:list-level-properties>
+   </text:list-level-style-number>
+   <text:list-level-style-number text:level="5" style:num-format="">
+    <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
+     <style:list-level-label-alignment text:label-followed-by="nothing"/>
+    </style:list-level-properties>
+   </text:list-level-style-number>
+   <text:list-level-style-number text:level="6" style:num-format="">
+    <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
+     <style:list-level-label-alignment text:label-followed-by="nothing"/>
+    </style:list-level-properties>
+   </text:list-level-style-number>
+   <text:list-level-style-number text:level="7" style:num-format="">
+    <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
+     <style:list-level-label-alignment text:label-followed-by="nothing"/>
+    </style:list-level-properties>
+   </text:list-level-style-number>
+   <text:list-level-style-number text:level="8" style:num-format="">
+    <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
+     <style:list-level-label-alignment text:label-followed-by="nothing"/>
+    </style:list-level-properties>
+   </text:list-level-style-number>
+   <text:list-level-style-number text:level="9" style:num-format="">
+    <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
+     <style:list-level-label-alignment text:label-followed-by="nothing"/>
+    </style:list-level-properties>
+   </text:list-level-style-number>
+   <text:list-level-style-number text:level="10" style:num-suffix="." style:num-format="1">
+    <style:list-level-properties text:list-level-position-and-space-mode="label-alignment">
+     <style:list-level-label-alignment text:label-followed-by="listtab" text:list-tab-stop-position="6.985cm" fo:text-indent="-0.635cm" fo:margin-left="6.985cm"/>
+    </style:list-level-properties>
+   </text:list-level-style-number>
+  </text:list-style>
   <text:notes-configuration text:note-class="footnote" text:citation-style-name="Footnote_20_Symbol" text:citation-body-style-name="Footnote_20_anchor" style:num-format="1" text:start-value="0" text:footnotes-position="page" text:start-numbering-at="document"/>
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   <text:bibliography-configuration text:prefix="[" text:suffix="]" fo:language="fr" fo:country="FR"/>
   <text:linenumbering-configuration text:number-lines="false" text:offset="0.499cm" style:num-format="1" text:number-position="left" text:increment="5"/>
+  <style:default-page-layout>
+   <style:page-layout-properties style:writing-mode="lr-tb" style:layout-grid-standard-mode="true"/>
+  </style:default-page-layout>
  </office:styles>
  <office:automatic-styles>
   <style:style style:name="P1" style:family="paragraph" style:parent-style-name="Footer">
@@ -1123,614 +1191,358 @@
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+    <text:p text:style-name="P1">JRES 2021 – Marseille<text:tab/><text:tab/><text:page-number text:select-page="current">8</text:page-number>/<text:page-count>8</text:page-count></text:p>
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-   <text:p text:style-name="P65">Edlira Nano</text:p>
-   <text:p text:style-name="P88">Associations April, </text:p>
-   <text:p text:style-name="P88">La Quadrature Du Net, </text:p>
-   <text:p text:style-name="P88">informaticienne indépendante</text:p>
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-   <text:p text:style-name="P71">Plateforme PAPPSO</text:p>
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-   <text:p text:style-name="P71">filippo.rusconi@universite-paris-saclay.fr</text:p>
+   <text:p text:style-name="P54">Logiciels libres : à la recherche du bien commun</text:p>
+   <text:p text:style-name="P31">Edlira Nano</text:p>
+   <text:p text:style-name="P36">Associations April, </text:p>
+   <text:p text:style-name="P36">La Quadrature Du Net, </text:p>
+   <text:p text:style-name="P36">informaticienne indépendante</text:p>
+   <text:p text:style-name="P36"><text:a xlink:type="simple" xlink:href="mailto:eda@mutu.net" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">eda@mutu.net</text:a> / eda@laquadrature.net</text:p>
+   <text:p text:style-name="P32">Olivier Langella</text:p>
+   <text:p text:style-name="P34">Ingénieur au CNRS</text:p>
+   <text:p text:style-name="P34">Plateforme PAPPSO</text:p>
+   <text:p text:style-name="P34">Laboratoire GQE-Le Moulon</text:p>
+   <text:p text:style-name="P34">Ferme du Moulon</text:p>
+   <text:p text:style-name="P34">91190 Gif-sur-Yvette</text:p>
+   <text:p text:style-name="P34">France</text:p>
+   <text:p text:style-name="P34">olivier.langella@universite-paris-saclay.fr</text:p>
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+   <text:p text:style-name="P33"><text:span text:style-name="T6">Filippo</text:span><text:span text:style-name="T30"> </text:span><text:span text:style-name="T6">Rusconi</text:span></text:p>
+   <text:p text:style-name="P55">Chercheur au CNRS</text:p>
+   <text:p text:style-name="P35">Plateforme <text:span text:style-name="T42">PAPPSO</text:span></text:p>
+   <text:p text:style-name="P34">Laboratoire GQE-Le Moulon</text:p>
+   <text:p text:style-name="P34">Ferme du Moulon</text:p>
+   <text:p text:style-name="P34">91190 Gif-sur-Yvette</text:p>
+   <text:p text:style-name="P34">France</text:p>
+   <text:p text:style-name="P34">filippo.rusconi@universite-paris-saclay.fr</text:p>
    <text:p text:style-name="Titre_20_résumé">Résumé</text:p>
-   <text:p text:style-name="P43"><text:change-start text:change-id="ct94407799201200"/>Ce document résume les instructions aux auteurs de la conférence JRES.</text:p>
-   <text:p text:style-name="P43"><text:change-end text:change-id="ct94407799201200"/>Le Logiciel libre et la recherche publique partagent un objectif : le bien commun, au service de tous. Cette présentation revient sur ce que sont le bien commun et la science ouverte pour essayer de les analyser à l&apos;aide de l&apos;exemple de la plateforme scientifique Analyses protéomiques de Paris Sud-Ouest(PAPPSO).</text:p>
-   <text:p text:style-name="P43"><text:line-break/>PAPPSO s&apos;est dotée d&apos;une infrastructure informatique complète basée exclusivement sur du Logiciel libre : réseau, serveurs, stockage, calcul et postes personnels. Elle développe plusieurs logiciels sous licence libre, dont ceux qui forment la chaîne de traitement des données de spectrométrie de masse. Ce choix naturel facilite la reproductibilité des traitements, apporte la maîtrise des logiciels et permet l&apos;intégration de code source tiers.</text:p>
-   <text:p text:style-name="P43"><text:line-break/>L&apos;apport majeur du Logiciel libre à la recherche publique permet l&apos;utilisation des réseaux et systèmes informatiques. Scientifiquement, l&apos;ouverture du code source et la liberté d&apos;utilisation des logiciels garantissent l&apos;échange des données, leur réutilisation et leur vérification par les pairs. Cet ensemble forme un bien commun protégé par des licences. De nombreux laboratoires y contribuent en utilisant ou en produisant des logiciels libres, comme en témoigne en partie la forge du code source du secteur public (<text:a xlink:type="simple" xlink:href="https://code.etalab.gouv.fr/" office:target-frame-name="_blank" xlink:show="new" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://code.etalab.gouv.fr</text:a>).</text:p>
-   <text:p text:style-name="P43"><text:line-break/>Comment contribuer efficacement ? Quelles sont les recommandations et obligations pour les <text:soft-page-break/>établissements publics ? Quelle licence choisir ? Comment une licence copyleft peut-elle aussi séduire les partenaires privés ? Nous apporterons des réponses et des éléments de réflexion pour corriger quelques fausses croyances et promouvoir la construction collective d&apos;une culture libre, au service du bien commun.<text:change-start text:change-id="ct94407800321840"/>Le résumé doit faire de quinze à vingt lignes. <text:span text:style-name="T40">Comme le reste du document, i</text:span><text:span text:style-name="T34">l utilise la </text:span><text:span text:style-name="T35">feuille de style Jres ; ici, </text:span><text:span text:style-name="T34">définition de</text:span><text:span text:style-name="T12"> style « </text:span><text:span text:style-name="T33">Résumé » : </text:span>écrit<text:span text:style-name="T33">ure</text:span> en italique, police avec empattement en taille 12 points. Le titre <text:span text:style-name="T33">utilisant le style </text:span>« <text:span text:style-name="T33">Titre r</text:span>ésumé » (ainsi que le titre « Mots-clefs » ci-dessous) sont en 14 points, gras, sans empattement.<text:change-end text:change-id="ct94407800321840"/></text:p>
+   <text:p text:style-name="P37"><text:change-start text:change-id="ct94011468841648"/>Ce document résume les instructions aux auteurs de la conférence JRES.</text:p>
+   <text:p text:style-name="P37"><text:change-end text:change-id="ct94011468841648"/>Le logiciel libre et la recherche publique partagent un objectif : le bien commun, au service de tous. Cette présentation revient sur ce que sont le bien commun et la science ouverte pour essayer de les analyser à l&apos;aide de l&apos;exemple de la plateforme scientifique Analyses protéomiques de Paris Sud-Ouest(PAPPSO).</text:p>
+   <text:p text:style-name="P37"><text:line-break/>PAPPSO s&apos;est dotée d&apos;une infrastructure informatique complète basée exclusivement sur du Logiciel libre : réseau, serveurs, stockage, calcul et postes personnels. Elle développe plusieurs logiciels sous licence libre, dont ceux qui forment la chaîne de traitement des données de spectrométrie de masse. Ce choix naturel facilite la reproductibilité des traitements, apporte la maîtrise des logiciels et permet l&apos;intégration de code source tiers.</text:p>
+   <text:p text:style-name="P37"><text:line-break/>L&apos;apport majeur du Logiciel libre à la recherche publique permet l&apos;utilisation des réseaux et systèmes informatiques. Scientifiquement, l&apos;ouverture du code source et la liberté d&apos;utilisation des logiciels garantissent l&apos;échange des données, leur réutilisation et leur vérification par les pairs. Cet ensemble forme un bien commun protégé par des licences. De nombreux laboratoires y contribuent en utilisant ou en produisant des logiciels libres, comme en témoigne en partie la forge du code source du secteur public (<text:a xlink:type="simple" xlink:href="https://code.etalab.gouv.fr/" office:target-frame-name="_blank" xlink:show="new" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://code.etalab.gouv.fr</text:a>).</text:p>
+   <text:p text:style-name="P37"><text:soft-page-break/><text:line-break/>Comment contribuer efficacement ? Quelles sont les recommandations et obligations pour les établissements publics ? Quelle licence choisir ? Comment une licence copyleft peut-elle aussi séduire les partenaires privés ? Nous apporterons des réponses et des éléments de réflexion pour corriger quelques fausses croyances et promouvoir la construction collective d&apos;une culture libre, au service du bien commun.<text:change-start text:change-id="ct94011468268960"/>Le résumé doit faire de quinze à vingt lignes. <text:span text:style-name="T13">Comme le reste du document, i</text:span><text:span text:style-name="T11">l utilise la </text:span><text:span text:style-name="T12">feuille de style Jres ; ici, </text:span><text:span text:style-name="T11">définition de</text:span><text:span text:style-name="T1"> style « </text:span><text:span text:style-name="T10">Résumé » : </text:span>écrit<text:span text:style-name="T10">ure</text:span> en italique, police avec empattement en taille 12 points. Le titre <text:span text:style-name="T10">utilisant le style </text:span>« <text:span text:style-name="T10">Titre r</text:span>ésumé » (ainsi que le titre « Mots-clefs » ci-dessous) sont en 14 points, gras, sans empattement.<text:change-end text:change-id="ct94011468268960"/></text:p>
    <text:p text:style-name="Titre_20_Mots-clés">Mots-clefs</text:p>
-   <text:p text:style-name="Mots-clefs"><text:change-start text:change-id="ct94407800399520"/><text:span text:style-name="T66">logiciel libre, </text:span><text:change-end text:change-id="ct94407800399520"/><text:change-start text:change-id="ct94407800399760"/><text:span text:style-name="T66">IPV6, PKI, CMS, </text:span><text:span text:style-name="T61">Calmar</text:span><text:span text:style-name="T66">…</text:span><text:change-end text:change-id="ct94407800399760"/><text:change-start text:change-id="ct94407800400000"/><text:span text:style-name="T66">licences</text:span><text:change-end text:change-id="ct94407800400000"/><text:change-start text:change-id="ct94407800400240"/><text:span text:style-name="T66">, </text:span><text:span text:style-name="T67">protéomique</text:span><text:change-end text:change-id="ct94407800400240"/></text:p>
+   <text:p text:style-name="Mots-clefs"><text:change-start text:change-id="ct94011468271280"/><text:span text:style-name="T17">logiciel libre, </text:span><text:change-end text:change-id="ct94011468271280"/><text:change-start text:change-id="ct94011468271696"/><text:span text:style-name="T17">IPV6, PKI, CMS, </text:span><text:span text:style-name="T15">Calmar</text:span><text:span text:style-name="T17">…</text:span><text:change-end text:change-id="ct94011468271696"/><text:span text:style-name="T43">logiciel scientifique, biens communs, recherche scientifique, </text:span><text:change-start text:change-id="ct94011468274032"/><text:span text:style-name="T17">licences</text:span><text:change-end text:change-id="ct94011468274032"/><text:change-start text:change-id="ct94011468791632"/><text:span text:style-name="T17">, </text:span><text:span text:style-name="T18">protéomique</text:span><text:change-end text:change-id="ct94011468791632"/></text:p>
    <text:p text:style-name="Mots-clefs"/>
-   <text:p text:style-name="P89">% <text:span text:style-name="T94">Ajouter </text:span>Intro : Poser le contexte, présenter le sujet, et faire le lien entre nos parties <text:span text:style-name="T94">puis annoncer le plan.</text:span></text:p>
-   <text:h text:style-name="Heading_20_1" text:outline-level="1"><text:change-start text:change-id="ct94407799862176"/>Introduction<text:change-end text:change-id="ct94407799862176"/><text:change-start text:change-id="ct94407800312128"/><text:span text:style-name="T26">Plateforme d’analyses protéomique</text:span><text:change-end text:change-id="ct94407800312128"/><text:change-start text:change-id="ct94407800386752"/><text:span text:style-name="T26">s</text:span></text:h>
-   <text:p text:style-name="P37"><text:change-end text:change-id="ct94407800386752"/><text:span text:style-name="T66">La protéomique est l’étude de l’ensemble des protéines produites par une cellule, un organe ou un organisme dans des conditions particulières ou en réponse à un traitement. Elle permet de </text:span><text:span text:style-name="T67">répondre à de nombreuses questions biologiques, de comprendre la physiologie ou différentes pathologie</text:span><text:span text:style-name="T83">s</text:span><text:span text:style-name="T67"> dans de</text:span><text:span text:style-name="T83">s espèces distinctes</text:span><text:span text:style-name="T67"> ou </text:span><text:span text:style-name="T83">dans des </text:span><text:span text:style-name="T67">groupes d’espèces (métaprotéomique). On peut connaître les protéines impliquées dans un processus biologique, ainsi que leur quantité et en déduire les caractéristiques de certains génomes ou lignées, </text:span><text:span text:style-name="T83">ou encore </text:span><text:span text:style-name="T67">comprendre la réponse physiologique liée à un stress</text:span><text:span text:style-name="T83">,</text:span><text:span text:style-name="T67"> par exemple.</text:span></text:p>
-   <text:p text:style-name="P19">Depuis 1997, date d’apparition du terme « protéomique », les techniques utilisées n’ont cessé d’évoluer. <text:span text:style-name="T83">Il s&apos;agit néanmoins toujours de mesurer la masse moléculaire des molécules qui pénètrent dans l&apos;instrument: un spectromètre de masse. </text:span><text:span text:style-name="T68">Dans une expérience de protéomique, les échantillons biologiques sont préparés, les protéines extraites, séparées par chromatographie et analysées par spectrométrie de masse</text:span><text:span text:style-name="T83">.</text:span></text:p>
-   <text:p text:style-name="P22">Les analyses <text:span text:style-name="T83">par</text:span> spectrométrie de masse produisent de grande<text:span text:style-name="T83">s</text:span> quantité<text:span text:style-name="T83">s</text:span> de données, <text:span text:style-name="T83">directement en sortie de l&apos;instrument. Chaque fabricant a son propre format de données, qui est le plus souvent propriétaire.</text:span> <text:span text:style-name="T83">Ordinairement, les données aux formats propriétaires sont traitées par les logiciels fournis avec l&apos;instrument, eux aussi propriétaires. Comme souvent dans le domaine des formats de fichiers, c</text:span>es formats ne sont pas pérennes<text:span text:style-name="T83"> et les licences d&apos;utilisation des logiciels propriétaires sont très coûteuses</text:span>. <text:span text:style-name="T83">Il y a donc ici un problème majeur d&apos;interopérabilité.</text:span></text:p>
-   <text:p text:style-name="P37"><text:span text:style-name="T69">Depuis 2005, </text:span><text:span text:style-name="T83">l</text:span><text:span text:style-name="T69">a plateforme scientifique </text:span><text:span text:style-name="T83">&quot;</text:span><text:span text:style-name="T69">Analyses protéomiques de Paris Sud-Ouest</text:span><text:span text:style-name="T83">&quot;</text:span><text:span text:style-name="T69"> (PAPPSO) a fait le choix du </text:span><text:span text:style-name="T91">L</text:span><text:span text:style-name="T69">ogiciel libre pour garantir la pérennité de ses chaînes de traitement, la reproductibilité des expériences et </text:span><text:span text:style-name="T83">la </text:span><text:span text:style-name="T69">capitalisation de son savoir faire.</text:span><text:change-start text:change-id="ct94407800412240"/></text:p>
-   <text:p text:style-name="P23">Il est recommandé d’utiliser <text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">la dernière version stable de Libre Office (au moment de la rédaction, v</text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T65">7</text:span></text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">.</text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T65">0</text:span></text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">.</text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T65">4</text:span></text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">)</text:a>.</text:p>
-   <text:p text:style-name="P37"><text:span text:style-name="T13">L</text:span>e document sera <text:span text:style-name="T13">finalement </text:span>transformé en format « Portable Document Format » (.pdf) pour la phase finale de publication.<text:change-end text:change-id="ct94407800412240"/></text:p>
-   <text:h text:style-name="P39" text:outline-level="2"><text:change-start text:change-id="ct94407800429200"/>Taille des articles<text:change-end text:change-id="ct94407800429200"/><text:span text:style-name="T21">Transition d</text:span><text:span text:style-name="T22">es</text:span><text:span text:style-name="T21"> logiciel</text:span><text:span text:style-name="T22">s</text:span><text:span text:style-name="T21"> propriétaire</text:span><text:span text:style-name="T22">s</text:span><text:span text:style-name="T21"> au </text:span><text:span text:style-name="T22">L</text:span><text:span text:style-name="T21">ogiciel libre</text:span></text:h>
-   <text:p text:style-name="P37"><text:change-start text:change-id="ct94407800430096"/>L’article doit faire entre 5 et 10 pages.<text:change-end text:change-id="ct94407800430096"/><text:span text:style-name="T70">Le passage progressif au </text:span><text:span text:style-name="T83">L</text:span><text:span text:style-name="T70">ogiciel libre a permis une rationalisation de l’utilisation des ressources informatiques. Nous sommes passés de postes dédiés à licence unique</text:span><text:span text:style-name="T83"> pour usage</text:span><text:span text:style-name="T70"> unique </text:span><text:span text:style-name="T71">à une infrastructure collective combinant stockage, calcul et enchaînement des traitements depuis n’importe quel poste de travail.</text:span></text:p>
-   <text:p text:style-name="P37"><text:span text:style-name="T72">Durant la période 2005–2015, notre travail a été facilité par la définition de formats standards en protéomique, l’émergence de nombreux logiciels libres dans le domaine </text:span><text:span text:style-name="T72"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4219_4199412181">[1]</text:bookmark-ref></text:span><text:span text:style-name="T72"><text:s/>et le développement en interne de nouvelles solutions </text:span><text:span text:style-name="T83">logicielles </text:span><text:span text:style-name="T73">(PROTICdb </text:span><text:span text:style-name="T73"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4321_4199412181">[2]</text:bookmark-ref></text:span><text:span text:style-name="T73">, mineXpert2 </text:span><text:span text:style-name="T73"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4323_4199412181">[3]</text:bookmark-ref></text:span><text:span text:style-name="T73">, X!TandemPipeline </text:span><text:span text:style-name="T73"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4176_4199412181">[4]</text:bookmark-ref></text:span><text:span text:style-name="T73">, MassChroQ </text:span><text:span text:style-name="T73"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4381_4199412181">[5]</text:bookmark-ref></text:span><text:span text:style-name="T73">)</text:span><text:span text:style-name="T72">.</text:span><text:change-start text:change-id="ct94407800423440"/></text:p>
-   <text:h text:style-name="P61" text:outline-level="2"><text:change-end text:change-id="ct94407800423440"/><text:soft-page-break/><text:span text:style-name="T83">Choix du s</text:span>ystème<text:span text:style-name="T83"> d&apos;exploitation</text:span><text:change-start text:change-id="ct94407800445312"/></text:h>
-   <text:p text:style-name="P37"><text:change-end text:change-id="ct94407800445312"/><text:span text:style-name="T73">Le choix de PAPPSO s’est porté d’abord sur </text:span><text:span text:style-name="T83">la distribution GNU/Linux </text:span><text:span text:style-name="T73">Ubuntu</text:span><text:span text:style-name="T83">,</text:span><text:span text:style-name="T73"> puis sur Debian. </text:span><text:span text:style-name="T83">Un groupe de développeurs officiels Debian, dont un auteur de ce rapport, s&apos;attache à fournir </text:span><text:span text:style-name="T84">dans la distribution </text:span><text:span text:style-name="T83">de </text:span><text:span text:style-name="T73">nombreux logiciels </text:span><text:span text:style-name="T83">pour la chimie, et en particulier pour la spectrométrie de masse (&quot;team debichem&quot;)</text:span><text:span text:style-name="T73">. L</text:span><text:span text:style-name="T83">&apos;intérêt principal de la </text:span><text:span text:style-name="T73">distribution Debian </text:span><text:span text:style-name="T83">est la richesse de son </text:span><text:span text:style-name="T73">offre </text:span><text:span text:style-name="T83">logicielle qui permet de disposer d&apos;</text:span><text:span text:style-name="T73">un socle </text:span><text:span text:style-name="T83">de fonctionnalités robuste</text:span><text:span text:style-name="T73"> </text:span><text:span text:style-name="T83">couvrant les exigences &quot;serveur&quot; et les impératifs &quot;</text:span><text:span text:style-name="T73">bureautique</text:span><text:span text:style-name="T83">&quot;</text:span><text:span text:style-name="T73">. </text:span><text:span text:style-name="T83">Tous les logiciels développés par PAPPSO sont disponibles</text:span><text:span text:style-name="T74"> sous forme de paquets Debian dans </text:span><text:span text:style-name="T83">des</text:span><text:span text:style-name="T74"> dépôt</text:span><text:span text:style-name="T83">s</text:span><text:span text:style-name="T74"> publi</text:span><text:span text:style-name="T83">cs</text:span><text:span text:style-name="T74">. </text:span><text:span text:style-name="T83">Le déploiement des </text:span><text:span text:style-name="T84">logiciels </text:span><text:span text:style-name="T74">sur les serveurs et les postes de travail de l’équipe</text:span><text:span text:style-name="T84"> </text:span><text:span text:style-name="T83">est ainsi </text:span><text:span text:style-name="T84">totalement automatisé.</text:span><text:change-start text:change-id="ct94407800444576"/></text:p>
-   <text:h text:style-name="P68" text:outline-level="2"><text:span text:style-name="T21">S</text:span><text:span text:style-name="T18">tockage</text:span></text:h>
-   <text:p text:style-name="P28"><text:change-end text:change-id="ct94407800444576"/>Les besoins en stockage de la plateforme évoluent constamment en fonction des progrès techniques. <text:span text:style-name="T84"><text:s/>Chaque nouvelle génération d&apos;instrument apporte des améliorations, en particulier sur la précision de mesure de masse, qui provoquent une augmentation significative du volume des données générées.</text:span> </text:p>
-   <text:p text:style-name="P28">Le système de stockage <text:span text:style-name="T84">des données de spectrométrie de masse </text:span>doit permettre une adaptation en continu de l<text:span text:style-name="T84">a</text:span> volumétrie <text:span text:style-name="T84">d&apos;espace disque </text:span>disponible ainsi que <text:span text:style-name="T84">l</text:span>es <text:span text:style-name="T84">meilleures </text:span>performances en lecture<text:span text:style-name="T84"> et </text:span>écriture. Les solutions classiques de type NAS ont été écartées pour éviter la dépendance matérielle et les problèmes liés au renouvellement des équipements.</text:p>
-   <text:p text:style-name="P44">Dès 2011, nous avons été parmi les premiers à faire confiance à une solution nouvelle de stockage distribué: Ceph. La principale caractéristique de ce système de stockage est de ne requérir que des serveurs standard. La flexibilité et l&apos;adaptabilité de ce système à des besoins perpétuellement en évolution en ont fait la solution la plus robuste que nous connaissions.</text:p>
-   <text:p text:style-name="P37"><draw:frame draw:style-name="fr1" draw:name="Image1" text:anchor-type="char" svg:x="3.106cm" svg:y="0.18cm" svg:width="10.788cm" svg:height="6.396cm" draw:z-index="0"><draw:image xlink:href="deluge/deluge.png" xlink:type="simple" xlink:show="embed" xlink:actuate="onLoad" draw:mime-type="image/png"/>
+   <text:p text:style-name="P39">% <text:span text:style-name="T38">Ajouter </text:span>Intro : Poser le contexte, présenter le sujet, et faire le lien entre nos parties <text:span text:style-name="T38">puis annoncer le plan.</text:span></text:p>
+   <text:h text:style-name="Heading_20_1" text:outline-level="1"><text:change-start text:change-id="ct94011468794384"/>Introduction<text:change-end text:change-id="ct94011468794384"/>Une p<text:change-start text:change-id="ct94011468794624"/><text:span text:style-name="T7">lateforme </text:span><text:change-end text:change-id="ct94011468794624"/><text:span text:style-name="T7">pour la recherche sous Logiciel libre</text:span></text:h>
+   <text:h text:style-name="Heading_20_2" text:outline-level="2">Contexte scientifique</text:h>
+   <text:p text:style-name="P10"><text:span text:style-name="T51">La </text:span><text:span text:style-name="T46">protéomique</text:span><text:span text:style-name="T51"> est l’étude de l’ensemble des protéines produites par une cellule, un organe ou un</text:span><text:span text:style-name="T46"><office:annotation>
+      <dc:creator>Michel Zivy</dc:creator>
+      <dc:date>2022-01-07T13:12:04.107907877</dc:date>
+      <text:p>j&apos;ai modifié les 2 premiers paragraphes du chapitre &quot;plateforme d&apos;analyse protéomique&quot;.</text:p>
+      <text:p>je pense que c&apos;est plus clair et complet (mais j&apos;ai perdu la généralisation à l&apos;analyse des protéines entières, Filippo ne va pas être content...) </text:p>
+     </office:annotation></text:span><text:span text:style-name="T51"> organisme . Elle permet d’analyser sans a priori les changements qualitatifs ou quantitatifs dans la composition en protéines en fonction de traitements, du développement ou de variations génétiques, et de comprendre par exemple comment un organisme répond à un stress ou à une maladie.</text:span></text:p>
+   <text:p text:style-name="P60">L’apparition du terme « protéomique » en 1995 coïncide avec le début de l’utilisation de la spectrométrie de masse pour l’identification des protéines puis pour leur quantification. Aujourd’hui la méthode utilisée quasi-exclusivement est l’analyse de peptides issus de la digestion tryptique des protéines, par un spectromètre de masse couplé à une chaîne de chromatographie liquide. Les appareils n’ont pas cessé d’évoluer mais au final il s’agit toujours de mesurer la masse moléculaire des peptides ayant pénétré dans le spectromètre et/ou de leurs fragments et de quantifier leur intensité.</text:p>
+   <text:p text:style-name="P3"><text:span text:style-name="T42">Les analyses </text:span><text:span text:style-name="T44">par</text:span><text:span text:style-name="T42"> spectrométrie de masse produisent de grande</text:span><text:span text:style-name="T44">s</text:span><text:span text:style-name="T42"> quan</text:span>tité<text:span text:style-name="T30">s</text:span> de données, <text:span text:style-name="T30">directement en sortie de l&apos;instrument. Chaque fabricant a son propre format de données, qui est le plus souvent propriétaire.</text:span> <text:span text:style-name="T30">Ordinairement, les données aux formats propriétaires sont traitées par les logiciels fournis avec l&apos;instrument, eux aussi propriétaires. Comme souvent dans le domaine des formats de fichiers, c</text:span>es formats ne sont pas pérennes<text:span text:style-name="T30"> et les licences d&apos;utilisation des logiciels propriétaires sont très coûteuses</text:span>. <text:span text:style-name="T30">Il y a donc ici un problème majeur d&apos;interopérabilité.</text:span></text:p>
+   <text:p text:style-name="P10"><text:span text:style-name="T19">Depuis 2005, </text:span><text:span text:style-name="T30">l</text:span><text:span text:style-name="T19">a plateforme scientifique </text:span><text:span text:style-name="T30">&quot;</text:span><text:span text:style-name="T19">Analyses protéomiques de Paris Sud-Ouest</text:span><text:span text:style-name="T30">&quot;</text:span><text:span text:style-name="T19"> (PAPPSO) a fait le choix du </text:span><text:span text:style-name="T36">L</text:span><text:span text:style-name="T19">ogiciel libre pour garantir la pérennité de ses chaînes de traitement, la reproductibilité des expériences et </text:span><text:span text:style-name="T30">la </text:span><text:span text:style-name="T19">capitalisation de son savoir faire.</text:span><text:change-start text:change-id="ct94011468796752"/></text:p>
+   <text:p text:style-name="P22">Il est recommandé d’utiliser <text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">la dernière version stable de Libre Office (au moment de la rédaction, v</text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T16">7</text:span></text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">.</text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T16">0</text:span></text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">.</text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T16">4</text:span></text:a><text:a xlink:type="simple" xlink:href="https://fr.libreoffice.org/download/telecharger-libreoffice/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">)</text:a>.</text:p>
+   <text:p text:style-name="P10"><text:span text:style-name="T2">L</text:span>e document sera <text:span text:style-name="T2">finalement </text:span>transformé en format « Portable Document Format » (.pdf) pour la phase finale de publication.<text:change-end text:change-id="ct94011468796752"/></text:p>
+   <text:h text:style-name="P43" text:outline-level="2"><text:change-start text:change-id="ct94011469200160"/>Taille des articles<text:change-end text:change-id="ct94011469200160"/><text:span text:style-name="T4">Transition d</text:span><text:span text:style-name="T5">es</text:span><text:span text:style-name="T4"> logiciel</text:span><text:span text:style-name="T5">s</text:span><text:span text:style-name="T4"> propriétaire</text:span><text:span text:style-name="T5">s</text:span><text:span text:style-name="T4"> au </text:span><text:span text:style-name="T5">L</text:span><text:span text:style-name="T4">ogiciel libre</text:span></text:h>
+   <text:p text:style-name="P10"><text:change-start text:change-id="ct94011469191536"/>L’article doit faire entre 5 et 10 pages.<text:change-end text:change-id="ct94011469191536"/><text:span text:style-name="T20">Le passage progressif au </text:span><text:span text:style-name="T44">L</text:span><text:span text:style-name="T45">ogiciel</text:span><text:span text:style-name="T20"> libre a permis une rationalisation de l’utilisation des ressources informatiques. Nous sommes passés de postes dédiés à licence unique</text:span><text:span text:style-name="T30"> pour usage</text:span><text:span text:style-name="T20"> unique </text:span><text:span text:style-name="T21">à une infrastructure collective combinant stockage, calcul et enchaînement des traitements depuis n’importe quel poste de travail.</text:span></text:p>
+   <text:p text:style-name="P10"><text:span text:style-name="T22">Durant la période 2005–2015, notre travail a été facilité par la définition de formats standards en protéomique, l’émergence de nombreux logiciels libres dans le domaine </text:span><text:span text:style-name="T22"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4219_4199412181">[1]</text:bookmark-ref></text:span><text:span text:style-name="T22"><text:s/>et le développement de </text:span><text:soft-page-break/><text:span text:style-name="T22">nouvelles solutions </text:span><text:span text:style-name="T30">logicielles sous licence libre </text:span><text:span text:style-name="T23">(PROTICdb </text:span><text:span text:style-name="T23"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4321_4199412181">[2]</text:bookmark-ref></text:span><text:span text:style-name="T23">, mineXpert2 </text:span><text:span text:style-name="T23"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4323_4199412181">[3]</text:bookmark-ref></text:span><text:span text:style-name="T23">, X!TandemPipeline </text:span><text:span text:style-name="T23"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4176_4199412181">[4]</text:bookmark-ref></text:span><text:span text:style-name="T23">, MassChroQ </text:span><text:span text:style-name="T23"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4381_4199412181">[5]</text:bookmark-ref></text:span><text:span text:style-name="T23">)</text:span><text:span text:style-name="T23"><text:note text:id="ftn1" text:note-class="footnote"><text:note-citation>1</text:note-citation><text:note-body>
+       <text:p text:style-name="Footnote">http://pappso.inrae.fr/</text:p></text:note-body></text:note></text:span><text:span text:style-name="T22">. </text:span><text:change-start text:change-id="ct94011468774032"/></text:p>
+   <text:h text:style-name="P44" text:outline-level="2"><text:change-end text:change-id="ct94011468774032"/><text:span text:style-name="T30">Choix du s</text:span>ystème<text:span text:style-name="T30"> d&apos;exploitation</text:span><text:change-start text:change-id="ct94011468929680"/></text:h>
+   <text:p text:style-name="P10"><text:change-end text:change-id="ct94011468929680"/><text:span text:style-name="T23">Le choix de PAPPSO s’est porté d’abord sur </text:span><text:span text:style-name="T30">la distribution GNU/Linux </text:span><text:span text:style-name="T23">Ubuntu</text:span><text:span text:style-name="T30">,</text:span><text:span text:style-name="T23"> puis sur Debian. </text:span><text:span text:style-name="T30">Un groupe de développeurs officiels Debian, dont un auteur de ce rapport, s&apos;attache à fournir </text:span><text:span text:style-name="T31">dans la distribution </text:span><text:span text:style-name="T30">de </text:span><text:span text:style-name="T23">nombreux logiciels </text:span><text:span text:style-name="T30">pour la chimie, et en particulier pour la spectrométrie de masse (&quot;team debichem&quot;)</text:span><text:span text:style-name="T23">. L</text:span><text:span text:style-name="T30">&apos;intérêt principal de la </text:span><text:span text:style-name="T23">distribution Debian </text:span><text:span text:style-name="T30">est la richesse de son </text:span><text:span text:style-name="T23">offre </text:span><text:span text:style-name="T30">logicielle qui permet de disposer d&apos;</text:span><text:span text:style-name="T23">un socle </text:span><text:span text:style-name="T30">de fonctionnalités robuste</text:span><text:span text:style-name="T23"> </text:span><text:span text:style-name="T30">couvrant les exigences &quot;serveur&quot; et les impératifs &quot;</text:span><text:span text:style-name="T23">bureautique</text:span><text:span text:style-name="T30">&quot;</text:span><text:span text:style-name="T23">. </text:span><text:span text:style-name="T30">Tous les logiciels développés par PAPPSO sont disponibles</text:span><text:span text:style-name="T24"> sous forme de paquets Debian dans </text:span><text:span text:style-name="T30">des</text:span><text:span text:style-name="T24"> dépôt</text:span><text:span text:style-name="T30">s</text:span><text:span text:style-name="T24"> publi</text:span><text:span text:style-name="T30">cs</text:span><text:span text:style-name="T24">. </text:span><text:span text:style-name="T30">Le déploiement des </text:span><text:span text:style-name="T31">logiciels, dépendances comprises, </text:span><text:span text:style-name="T24">sur les serveurs et les postes de travail de l’équipe</text:span><text:span text:style-name="T31"> </text:span><text:span text:style-name="T30">est ainsi simplifié et </text:span><text:span text:style-name="T31">totalement automatisé.</text:span><text:change-start text:change-id="ct94011469192720"/></text:p>
+   <text:h text:style-name="P51" text:outline-level="2"><text:span text:style-name="T4">S</text:span><text:span text:style-name="T3">tockage</text:span><text:change-end text:change-id="ct94011469192720"/><text:span text:style-name="T3"> des données</text:span><text:change-start text:change-id="ct94011469442768"/></text:h>
+   <text:p text:style-name="P4"><text:change-end text:change-id="ct94011469442768"/>Les besoins en stockage de la plateforme évoluent constamment en fonction des progrès techniques des spectromètres de masse. <text:s/><text:span text:style-name="T31"><text:s/>Chaque nouvelle génération d&apos;instruments apporte des améliorations, en particulier sur la précision de mesure de masse, qui provoquent une augmentation significative du volume des données générées.</text:span> Cette progression des besoins en volume de stockage sur les quinze dernières années est illustrée dans la figure ci-dessous.</text:p>
+   <text:p text:style-name="P4">Le système de stockage <text:span text:style-name="T31">des données de spectrométrie de masse </text:span>doit permettre une adaptation en continu de l<text:span text:style-name="T31">a</text:span> volumétrie <text:span text:style-name="T31">d&apos;espace disque </text:span>disponible ainsi que <text:span text:style-name="T31">l</text:span>es <text:span text:style-name="T31">meilleures </text:span>performances en lecture<text:span text:style-name="T31"> et </text:span>écriture. Les solutions classiques de type NAS ont été écartées pour éviter la dépendance matérielle et les problèmes liés au renouvellement des équipements.</text:p>
+   <text:p text:style-name="P11">Dès 2011, nous avons été parmi les premiers à faire confiance à une solution nouvelle de stockage distribué: Ceph<text:note text:id="ftn2" text:note-class="footnote"><text:note-citation>2</text:note-citation><text:note-body>
+      <text:p text:style-name="Footnote"><text:span text:style-name="T42">https://ceph.io/</text:span><text:span text:style-name="T42"><office:annotation>
+         <dc:creator>Rusconi (Guest)</dc:creator>
+         <dc:date>2022-01-07T12:43:03.185399034</dc:date>
+         <text:p>Olivier, c&apos;est bien ce site, non ?</text:p>
+        </office:annotation></text:span><text:span text:style-name="T42"><office:annotation>
+         <dc:creator>Olivier Langella</dc:creator>
+         <dc:date>2022-01-07T12:57:45.281774077</dc:date>
+         <text:p>ceph.io, ça évite de tomber chez redhat</text:p>
+        </office:annotation></text:span></text:p></text:note-body></text:note>. La principale caractéristique de ce système de stockage est de ne requérir que des serveurs standard. La flexibilité et l&apos;adaptabilité de ce système à des besoins perpétuellement en évolution en ont fait<office:annotation office:name="__Annotation__1473_3826984812111" loext:resolved="false">
+     <dc:creator>Rusconi (Guest)</dc:creator>
+     <dc:date>2022-01-07T12:54:19.075460059</dc:date>
+     <text:p>Idéalement, cette figure irait juste en-dessous du premier parg. de cette section ?</text:p>
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+     </draw:image>
+    </draw:frame><office:annotation-end office:name="__Annotation__1473_3826984812111"/><text:span text:style-name="T30"><office:annotation>
+      <dc:creator>Olivier Langella</dc:creator>
+      <dc:date>2022-01-07T15:43:48.374133582</dc:date>
+      <text:p>A ne pas oublier déplacement après le premier paragraphe</text:p>
+     </office:annotation></text:span> la solution la plus robuste que nous connaissions.</text:p>
+   <text:p text:style-name="P10"/>
+   <text:p text:style-name="P29"><text:span text:style-name="T14">Figure </text:span><text:span text:style-name="T14"><text:sequence text:ref-name="refFigure0" text:name="Figure" text:formula="ooow:Figure+1" style:num-format="1">1</text:sequence></text:span><text:span text:style-name="T14"><text:s/>– </text:span><text:span text:style-name="T33">Evolution des besoins de stockage de la plateforme en To/an, comparée à l’évolution des disques durs</text:span><text:change-start text:change-id="ct94011469638816"/></text:p>
+   <text:h text:style-name="P45" text:outline-level="2"><text:soft-page-break/>Calcul<text:change-end text:change-id="ct94011469638816"/> scientifique<text:change-start text:change-id="ct94011469642368"/></text:h>
+   <text:p text:style-name="P5"><text:change-end text:change-id="ct94011469642368"/>La plateforme PAPPSO est <text:span text:style-name="T42">spécialisée</text:span> dans les traitements en protéomique haut débit (nombreux échantillons<text:span text:style-name="T31"> à traiter dans les plus brefs délais</text:span>). Pour assurer la disponibilité de nos moyens de calcul à l’ensemble des utilisateurs, nous utilisons le gestionnaire de processus HTCondor<text:note text:id="ftn3" text:note-class="footnote"><text:note-citation>3</text:note-citation><text:note-body>
+      <text:p text:style-name="Footnote">https://htcondor.org/</text:p></text:note-body></text:note>.</text:p>
+   <text:p text:style-name="P5">Les besoins en calcul évoluent eux aussi en fonction des instruments utilisés. Avec l<text:span text:style-name="T42">’évolution des techniques, de nouvelles possibilités sont apparues dans le traitement de données en</text:span> protéomique, exigeant elles aussi des capacités de calcul supplémentaires. De la même manière que pour les capacités de stockage, les machines dédiées au calcul doivent être ainsi renouvelées régulièrement et intégrées au fur et à mesure.<text:span text:style-name="T42"> </text:span></text:p>
+   <text:h text:style-name="P40" text:outline-level="1">Retour d’expérience sur 10 <text:span text:style-name="T49">ans</text:span></text:h>
+   <text:h text:style-name="P46" text:outline-level="2">Matériel</text:h>
+   <text:p text:style-name="P6">L’<text:span text:style-name="T25">intégration de nouvelles machines de calcul ou de stockage s’est faite de manière transparente. Nous sommes passés d’une capacité de stockage initiale de 18To (3 serveurs R515, disques de 3To) en 2011 à une capacité de 917To (8 serveurs hétérogènes). Le réseau est passé du 1Gb cuivre au 10Gb SFP+. Il n’y a pas eu de transfert de données/migration, pas de modification de l’architecture logique pour les utilisateurs. Le système de fichier</text:span><text:span text:style-name="T31">s</text:span><text:span text:style-name="T25"> cephfs permet un accès direct aux données depuis chaque nœud de calcul</text:span><text:span text:style-name="T31">. Globalement</text:span><text:span text:style-name="T25">, les performances ont suivi les évolutions matérielles (augmentation du débit, augmentation des capacités de calcul). La résistance aux pannes a été mise à rude épreuve (panne électrique, disques ou erreurs humaines) et nous n’avons </text:span><text:span text:style-name="T31">jamais</text:span><text:span text:style-name="T25"> eu de perte de données.</text:span></text:p>
+   <text:h text:style-name="P47" text:outline-level="2">Logiciel</text:h>
+   <text:p text:style-name="P7">Les systèmes <text:span text:style-name="T31">pour les </text:span>serveurs et <text:span text:style-name="T31">pour les postes </text:span>utilisateur ont été migrés en 2013 de Ubuntu GNU/Linux vers Debian. Nous y avons gagné en stabilité et en simplicité lors des mises à jour de version. <text:span text:style-name="T31">La stratégie consiste à maintenir le parc informatique sous Debian &quot;stable&quot; et effectuer le passage à la version successive dans les mois qui suivent sa publication officielle. </text:span>Le stockage centralisé est disponible pour tous les postes dans une arborescence commune,<text:span text:style-name="T31"> via un</text:span> montage automatique sur les nœud de calculs (cephfs via systemd sur les serveurs, sshfs sur les postes clients). Les logiciels sont les mêmes sur les serveurs et les postes utilisateurs. L’accès distant au cluster de calcul se fait avec x2go, via <text:span text:style-name="T31">une </text:span>clé publique ssh.</text:p>
+   <text:h text:style-name="P48" text:outline-level="2">Scientifique</text:h>
+   <text:p text:style-name="P10"><text:span text:style-name="T26">Les analyses de la plateforme ont évolué pour passer de la technique des gels d’électrophorèse 2D vers des analyses uniquement basées sur la spectrométrie de masse. Le traitement des images des gels 2D était majoritairement effectué avec des logiciels propriétaires sous Windows</text:span><text:span text:style-name="T35">, sur des </text:span><text:span text:style-name="T26">postes dédiés, ce qui limitait les capacités de traitement. </text:span><text:span text:style-name="T35">Le passage progressif à des processus analytiques qui faisaient l&apos;économie de l&apos;étape d&apos;électrophorèse a coincidé avec les apports massif du Logiciel libre dans le domaine scientifique, au milieu des années 2000. Nous avons alors pu commencer la transition vers certains </text:span><text:span text:style-name="T26">logiciels libres qui émergeaient à cette époque. </text:span><text:span text:style-name="T35">Cependant, ces logiciels étaient principalement des librairies encore imparfaitement dotées des fonctionnalités requises <text:s/>dans notre domaine. </text:span><text:span text:style-name="T26">Nous avons </text:span><text:span text:style-name="T35">alors entrepris le </text:span><text:span text:style-name="T26">développe</text:span><text:span text:style-name="T35">ment</text:span><text:span text:style-name="T26"> </text:span><text:span text:style-name="T35">de nos logiciels sur la base des besoins scientifiques particuliers à notre plateforme</text:span><text:span text:style-name="T27">. </text:span><text:span text:style-name="T34">Le logiciel </text:span><text:span text:style-name="T27"><text:s/>MassChroQ</text:span><text:span text:style-name="T34"> est né ainsi, de nos besoins en protéomique quantitative</text:span><text:span text:style-name="T27">. </text:span><text:span text:style-name="T34">Notre </text:span><text:span text:style-name="T27">indépendance vis</text:span><text:span text:style-name="T34">-</text:span><text:span text:style-name="T27">à</text:span><text:span text:style-name="T34">-</text:span><text:span text:style-name="T27">vis des formats</text:span><text:span text:style-name="T34"> de données propriétaires </text:span><text:span text:style-name="T27">des fabricants nous a permis de produire un logiciel évolutif et pérenne dès le départ, évitant l’effet </text:span><text:soft-page-break/><text:span text:style-name="T27">« boîte noire ». Ainsi, no</text:span><text:span text:style-name="T32">tre</text:span><text:span text:style-name="T27"> </text:span><text:span text:style-name="T34">offre logicielle a</text:span><text:span text:style-name="T27"> pu être adapté</text:span><text:span text:style-name="T34">e</text:span><text:span text:style-name="T27"> au fur et à mesure aux nouvelles techniques</text:span><text:span text:style-name="T34">, à des </text:span><text:span text:style-name="T27">instruments</text:span><text:span text:style-name="T34"> significativement différents de génération en génération</text:span><text:span text:style-name="T27">, absorbant </text:span><text:span text:style-name="T34">ainsi </text:span><text:span text:style-name="T27">les « chocs » technologiques : doublement des fréquences d’acquisition à chaque génération (3 ans), doublement d</text:span><text:span text:style-name="T34">u pouvoir</text:span><text:span text:style-name="T27"> résoluti</text:span><text:span text:style-name="T34">f</text:span><text:span text:style-name="T27"> (précision de</text:span><text:span text:style-name="T34">s</text:span><text:span text:style-name="T27"> mesure</text:span><text:span text:style-name="T34">s</text:span><text:span text:style-name="T27"> des masse).</text:span></text:p>
+   <text:p text:style-name="P10"><text:span text:style-name="T27">La dernière « rupture technologique » </text:span><text:span text:style-name="T34">a été</text:span><text:span text:style-name="T27"> l’apparition du tim</text:span><text:span text:style-name="T31">s</text:span><text:span text:style-name="T27">TOF </text:span><text:span text:style-name="T34">P</text:span><text:span text:style-name="T27">ro du fabricant Bruker. Cet appareil dispose d’une fréquence d’acquisition 10 fois </text:span><text:span text:style-name="T34">supérieure à celle de</text:span><text:span text:style-name="T27"> la génération précédente ainsi que d’une nouvelle dimension de séparation des peptides (mobilité ionique). Fait unique depuis les débuts de la protéomique, Bruker </text:span><text:span text:style-name="T34">nous </text:span><text:span text:style-name="T27">a </text:span><text:span text:style-name="T34">confié </text:span><text:span text:style-name="T27">les spécifications techniques de son </text:span><text:span text:style-name="T34">format de fichier de données</text:span><text:span text:style-name="T27">. Cela nous a permis d’adapter MassChroQ pour pouvoir utiliser </text:span><text:span text:style-name="T34">de manière native</text:span><text:span text:style-name="T27"> les données </text:span><text:span text:style-name="T34">obtenues sur cet instrument</text:span><text:span text:style-name="T27">. No</text:span><text:span text:style-name="T34">tre savoir faire en développment C++ nous a ainsi permis d&apos;obtenir</text:span><text:span text:style-name="T27"> des gains de performances remarquables par rapport aux logiciels commerciaux, ainsi que de meilleurs </text:span><text:span text:style-name="T34">résultats scientifiques</text:span><text:span text:style-name="T27">.</text:span></text:p>
+   <text:p text:style-name="P8"/>
+   <text:h text:style-name="P41" text:outline-level="1">Bilan <text:span text:style-name="T37">(</text:span>%<text:span text:style-name="T37">eda :</text:span> <text:span text:style-name="T37">mettre ce paragraphe en 2.4 et garder le 3 </text:span><text:span text:style-name="T50"><office:annotation>
+      <dc:creator>Olivier Langella</dc:creator>
+      <dc:date>2022-01-07T12:06:46.767924996</dc:date>
+      <text:p>ok pour moi, on fait le bilan à la fin, on recase ça</text:p>
+     </office:annotation></text:span><text:span text:style-name="T37">pour ma partie?)</text:span></text:h>
+   <text:p text:style-name="P10"><text:span text:style-name="T28">Le passage au </text:span><text:span text:style-name="T34">L</text:span><text:span text:style-name="T28">ogiciel libre pour </text:span><text:span text:style-name="T34">tous les besoins informatiques de </text:span><text:span text:style-name="T28">la plateforme PAPPSO a permis une maîtrise totale de ses outils, de</text:span><text:span text:style-name="T34">pui</text:span><text:span text:style-name="T32">s</text:span><text:span text:style-name="T28"> la production des données brutes </text:span><text:span text:style-name="T34">ju</text:span><text:span text:style-name="T32">s</text:span><text:span text:style-name="T34">qu’</text:span><text:span text:style-name="T28">à l’interprétation biologique. Les sommes importantes économisées en licences de logiciels propriétaires (20k€ par an) ont été investies dans la maintenance des ressources de calcul et de stockage. Le savoir faire développé par PAPPSO dans l’analyse protéomique à haut débit est reconnu au niveau international (129 articles citant MassChroQ depuis 2011, </text:span><text:span text:style-name="T29">publication d’un article de référence en métaprotéomique </text:span><text:span text:style-name="T29"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4411_4199412181">[6]</text:bookmark-ref></text:span><text:span text:style-name="T32">)</text:span><text:span text:style-name="T29">. Toutes les analyses sont complètement vérifiables et reproductibles, les logiciels étant tous librement </text:span><text:span text:style-name="T34">téléchargeables, </text:span><text:span text:style-name="T29">sous licence GPLv3+</text:span><text:span text:style-name="T34">, sans demande préalable</text:span><text:span text:style-name="T29">.</text:span></text:p>
+   <text:p text:style-name="P10"/>
+   <text:h text:style-name="P42" text:outline-level="1">Importance et apports du libre dans la recherche scientifique</text:h>
+   <text:h text:style-name="P49" text:outline-level="2">Importance</text:h>
+   <text:p text:style-name="P53"/>
+   <text:p text:style-name="P23">La recherche publique vise <text:s/>à produire et à développer des connaissances, les améliorer sans cesse, puis les faire connaître et les transmettre au public. Dans ce travail incrémental, il est crucial de pouvoir partir de l’existant, ne pas réinventer sans cesse ce qu’on a déjà acquis, pour pouvoir le préciser, l’améliorer ou le rejetter si besoin. Le partage de la connaissance semble naturellement indispensable dans ce processus. Tout comme semble naturelle la possibilité de réutiliser le travail déjà effectué, et les résultats auparavant obtenus, de pouvoir modifier et adapter ceux-ci, plûtot que de devoir à chaque fois repartir de zéro. De pouvoir ensuite à son tour partager et diffuser ses résultats, ainsi obtenus à l’aide de ceux des autres, en y ajoutant à chaque fois une nouveauté, modification, précision. </text:p>
+   <text:p text:style-name="P25"/>
+   <text:p text:style-name="P23">Vous avez là la définition d’un logiciel libre ou plus largement d’un bien libre. La culture du libre n’est pas unique aux logiciels, elle peut concerner un logiciel, un service informatique en ligne, un document (article scientifique, livre, poème, rapport) un produit artistique (oeuvre numérique, production graphique, reproduction numérique d’une œuvre physique comme par exemple les tableaux d’un musée, les photos de monuments etc), une semence agricole (les graines libres de <text:soft-page-break/>droit), un médicament libre, etc. Une œuvre / bien libre est quelque chose qu’on peut utiliser librement, <text:s/>partager librement, distribuer librement autour de nous, mais aussi modifier le contenu, l’adapter, l’améliorer, pour pouvoir ensuite librement le repartager, redistribuer etc. Cette liberté n’est pas sans règles : on doit souvent (pas toujours selon la licence choisie) attribuer la paternité / maternité de l’oeuvre (le droit d’auteur) et parfois on doit aussi lors de modifications et redistributions de ces versions modifiées, <text:s/>s’assurer que cette version qui en découle bénéficie de ces mêmes obligations en termes de libertés : on parle alors de conditions de copyleft, le sharealike en anglais, le SA des licences creatives commons. </text:p>
+   <text:p text:style-name="P23"/>
+   <text:p text:style-name="P23">La recherche publique et le mouvement du libre ont toutes deux un objectif commun : <text:s/>partager la connaissance librement, au service de tous.</text:p>
+   <text:p text:style-name="P24"/>
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     </draw:frame></text:p>
-   <text:p text:style-name="P45"><text:span text:style-name="T47">Figure </text:span><text:span text:style-name="T47"><text:sequence text:ref-name="refFigure0" text:name="Figure" text:formula="ooow:Figure+1" style:num-format="1">1</text:sequence></text:span><text:span text:style-name="T47"><text:s/>– </text:span><text:span text:style-name="T86">Evolution des besoins de stockage de la plateforme en To/an, comparée à l’évolution des disques durs</text:span><text:change-start text:change-id="ct94407800482704"/></text:p>
-   <text:h text:style-name="P59" text:outline-level="2">Calcul</text:h>
-   <text:p text:style-name="P30"><text:change-end text:change-id="ct94407800482704"/>La plateforme PAPPSO est spécialisée dans les traitements en protéomique haut débit (nombreux échantillons<text:span text:style-name="T84"> à traiter dans les plus brefs délais</text:span>). Pour assurer la disponibilité de nos moyens de calcul à l’ensemble des utilisateurs, nous utilisons le gestionnaire de processus HTCondor.</text:p>
-   <text:p text:style-name="P30"><text:soft-page-break/>Les besoins en calcul évoluent eux aussi en fonction des instruments utilisés. Avec l’évolution des techniques, de nouvelles possibilités sont apparues dans le traitement de données en protéomique exigeant elles aussi des capacités de calcul supplémentaires. Les machines dédiées au calcul doivent être ainsi renouvelées régulièrement et intégrées au fur et à mesure (comme pour le stockage).</text:p>
-   <text:h text:style-name="P57" text:outline-level="1">Evolution sur 10 ans</text:h>
-   <text:h text:style-name="P62" text:outline-level="2">Matériel</text:h>
-   <text:p text:style-name="P32">L’<text:span text:style-name="T77">intégration de nouvelles machines de calcul ou de stockage s’est faite de manière transparente. Nous sommes passés d’une capacité de stockage initiale de 18To (3 serveurs R515, disques de 3To) en 2011 à une capacité de 917To (8 serveurs hétérogènes). Le réseau est passé du 1Gb cuivre au 10Gb SFP+. Il n’y a pas eu de transfert de données/migration, pas de modification de l’architecture logique pour les utilisateurs. Le système de fichier</text:span><text:span text:style-name="T84">s</text:span><text:span text:style-name="T77"> cephfs permet un accès direct aux données depuis chaque nœud de calcul</text:span><text:span text:style-name="T84">. Globalement</text:span><text:span text:style-name="T77">, les performances ont suivi les évolutions matérielles (augmentation du débit, augmentation des capacités de calcul). La résistance aux pannes a été mise à rude épreuve (panne électrique, disques ou erreurs humaines) et nous n’avons </text:span><text:span text:style-name="T84">jamais</text:span><text:span text:style-name="T77"> eu de perte de données.</text:span></text:p>
-   <text:h text:style-name="P63" text:outline-level="2">Logiciel</text:h>
-   <text:p text:style-name="P34">Les systèmes <text:span text:style-name="T84">pour les </text:span>serveurs et <text:span text:style-name="T84">pour les postes </text:span>utilisateur ont été migrés en 2013 de Ubuntu vers Debian. Nous y avons gagné en stabilité et en simplicité lors des mises à jour de version. <text:span text:style-name="T84">La stratégie consiste à maintenir le parc informatique sous Debian &quot;stable&quot; et effectuer le passage à la version successive dans les mois qui suivent sa publication officielle. </text:span>Le stockage centralisé est disponible pour tous les postes dans une arborescence commune,<text:span text:style-name="T84"> via un</text:span> montage automatique sur les nœud de calculs (cephfs via systemd sur les serveurs, sshfs sur les postes clients). Les logiciels sont les mêmes sur les serveurs et les postes utilisateurs. L’accès distant au cluster de calcul se fait avec x2go via <text:span text:style-name="T84">une </text:span>clé publique ssh.</text:p>
-   <text:h text:style-name="P64" text:outline-level="2">Scientifique</text:h>
-   <text:p text:style-name="P37"><text:span text:style-name="T78">Les analyses de la plateforme ont évolué pour passer de la technique des gels électrophorèses 2D vers les analyses shotgun en spectrométrie de masse. Le traitement d’images 2D était majoritairement effectué avec des logiciels propriétaires sous Windows</text:span><text:span text:style-name="T88">, sur des </text:span><text:span text:style-name="T78">postes dédiés, ce qui limitait les capacités de traitement. </text:span><text:span text:style-name="T88">Le passage progressif à des processus analytiques qui faisaient l&apos;économie de l&apos;étape d&apos;électrophorèse a coincidé avec la révolution du Logiciel libre dans le domaine scientifique au milieu des années 2000. Nous avons alors pu effectuer la transition vers des </text:span><text:span text:style-name="T78">logiciels libres. </text:span><text:span text:style-name="T88">Cependant, les logiciels disponibles étaient principalement des librairies encore imparfaitement dotées des fonctionnalités requises. </text:span><text:span text:style-name="T78">Nous avons </text:span><text:span text:style-name="T88">alors entrepris le </text:span><text:span text:style-name="T78">développe</text:span><text:span text:style-name="T88">ment</text:span><text:span text:style-name="T78"> </text:span><text:span text:style-name="T88">de nos logiciels sur la base des besoins scientifiques particuliers à notre plateforme</text:span><text:span text:style-name="T79">. </text:span><text:span text:style-name="T87">Le logiciel </text:span><text:span text:style-name="T79"><text:s/>MassChroQ</text:span><text:span text:style-name="T87"> est né ainsi, de nos besoins en protéomique quantitative</text:span><text:span text:style-name="T79">. </text:span><text:span text:style-name="T87">Note </text:span><text:span text:style-name="T79">indépendance vis</text:span><text:span text:style-name="T87">-</text:span><text:span text:style-name="T79">à</text:span><text:span text:style-name="T87">-</text:span><text:span text:style-name="T79">vis des formats</text:span><text:span text:style-name="T87"> de données propriétaires </text:span><text:span text:style-name="T79">des fabricants nous a permis de produire un logiciel évolutif et pérenne dès le départ, évitant l’effet « boîte noire ». Ainsi, no</text:span><text:span text:style-name="T85">tre</text:span><text:span text:style-name="T79"> </text:span><text:span text:style-name="T87">offre logicielle a</text:span><text:span text:style-name="T79"> pu être adapté</text:span><text:span text:style-name="T87">e</text:span><text:span text:style-name="T79"> au fur et à mesure aux nouvelles techniques</text:span><text:span text:style-name="T87">, à des </text:span><text:span text:style-name="T79">instruments</text:span><text:span text:style-name="T87"> significativement différents de génération en génération</text:span><text:span text:style-name="T79">, absorbant </text:span><text:span text:style-name="T87">ainsi </text:span><text:span text:style-name="T79">les « chocs » technologiques : doublement des fréquences d’acquisition à chaque génération (3 ans), doublement d</text:span><text:span text:style-name="T87">u pouvoir</text:span><text:span text:style-name="T79"> résoluti</text:span><text:span text:style-name="T87">f</text:span><text:span text:style-name="T79"> (précision de</text:span><text:span text:style-name="T87">s</text:span><text:span text:style-name="T79"> mesure</text:span><text:span text:style-name="T87">s</text:span><text:span text:style-name="T79"> des masse).</text:span></text:p>
-   <text:p text:style-name="P37"><text:span text:style-name="T79">La dernière « rupture technologique » </text:span><text:span text:style-name="T87">a été</text:span><text:span text:style-name="T79"> l’apparition du tim</text:span><text:span text:style-name="T84">s</text:span><text:span text:style-name="T79">TOF </text:span><text:span text:style-name="T87">P</text:span><text:span text:style-name="T79">ro du fabricant Bruker. Cet appareil dispose d’une fréquence d’acquisition 10 fois </text:span><text:span text:style-name="T87">supérieure à celle de</text:span><text:span text:style-name="T79"> la génération précédente </text:span><text:soft-page-break/><text:span text:style-name="T79">ainsi que d’une nouvelle dimension de séparation des peptides (mobilité ionique). Fait unique depuis les débuts de la protéomique, Bruker </text:span><text:span text:style-name="T87">nous </text:span><text:span text:style-name="T79">a </text:span><text:span text:style-name="T87">confié </text:span><text:span text:style-name="T79">les spécifications techniques de son </text:span><text:span text:style-name="T87">format de fichier de données</text:span><text:span text:style-name="T79">. Cela nous a permis d’adapter MassChroQ pour pouvoir utiliser </text:span><text:span text:style-name="T87">de manière native</text:span><text:span text:style-name="T79"> les données </text:span><text:span text:style-name="T87">obtenues sur cet instrument</text:span><text:span text:style-name="T79">. No</text:span><text:span text:style-name="T87">tre savoir faire en développment C++ nous a ainsi permis d&apos;obtenir</text:span><text:span text:style-name="T79"> des gains de performances remarquables par rapport aux logiciels commerciaux, ainsi que de meilleurs </text:span><text:span text:style-name="T87">résultats scientifiques</text:span><text:span text:style-name="T79">.</text:span></text:p>
-   <text:p text:style-name="P35"/>
-   <text:h text:style-name="P58" text:outline-level="1">Bilan <text:span text:style-name="T92">(</text:span>%<text:span text:style-name="T92">eda :</text:span> <text:span text:style-name="T92">mettre ce paragraphe en 2.4 et garder le 3 pour ma partie?)</text:span></text:h>
-   <text:p text:style-name="P37"><text:span text:style-name="T80">Le passage au </text:span><text:span text:style-name="T87">L</text:span><text:span text:style-name="T80">ogiciel libre pour </text:span><text:span text:style-name="T87">tous les besoins informatiques de </text:span><text:span text:style-name="T80">la plateforme PAPPSO a permis une maîtrise totale de ses outils, de</text:span><text:span text:style-name="T87">pui</text:span><text:span text:style-name="T85">s</text:span><text:span text:style-name="T80"> la production des données brutes </text:span><text:span text:style-name="T87">ju</text:span><text:span text:style-name="T85">s</text:span><text:span text:style-name="T87">qu’</text:span><text:span text:style-name="T80">à l’interprétation biologique. Les sommes importantes économisées en licences de logiciels propriétaires (20k€ par an) ont été transférées dans la maintenance des ressources de calcul et de stockage. Le savoir faire développé par PAPPSO dans l’analyse protéomique haut débit est reconnu au niveau international (129 articles citant MassChroQ depuis 2011, </text:span><text:span text:style-name="T81">publication d’un article de référence en métaprotéomique </text:span><text:span text:style-name="T81"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4411_4199412181">[6]</text:bookmark-ref></text:span><text:span text:style-name="T85">)</text:span><text:span text:style-name="T81">. Toutes les analyses sont complètement vérifiables et reproductibles, les logiciels étant tous librement </text:span><text:span text:style-name="T87">téléchargeables, </text:span><text:span text:style-name="T81">sous licence GPLv3</text:span><text:span text:style-name="T87">, sans demande préalable</text:span><text:span text:style-name="T81">.</text:span></text:p>
-   <text:p text:style-name="P37"/>
-   <text:h text:style-name="P78" text:outline-level="1"><text:span text:style-name="T28">Importance et apports du libre dans la recherche scientifique</text:span></text:h>
-   <text:h text:style-name="P86" text:outline-level="2"><text:span text:style-name="T28">Importance</text:span></text:h>
-   <text:p text:style-name="P96">* <text:span text:style-name="T92">idéologique : </text:span><text:span text:style-name="T97">idée de contribution aux communs, revenir sur l’histoire et la fonction de la recherche publique, notion de liberté et d’éthique du travail public </text:span></text:p>
-   <text:p text:style-name="P93">* <text:span text:style-name="T92">scientifique :</text:span><text:span text:style-name="T97">, parler de la campagne public money public code, // avec l’édition libre et culture libre en général</text:span></text:p>
-   <text:p text:style-name="P93">* <text:span text:style-name="T92">pratico-pragmatique </text:span></text:p>
-   <text:h text:style-name="P86" text:outline-level="2"><text:span text:style-name="T28">Apport</text:span><text:span text:style-name="T29">s</text:span></text:h>
-   <text:p text:style-name="P94">* <text:span text:style-name="T92">scientifique </text:span><text:span text:style-name="T94">(PAPPSO ci dessus)</text:span></text:p>
-   <text:p text:style-name="P94">* <text:span text:style-name="T95">informatique: sécurité, communauté, auditable etc ...</text:span></text:p>
-   <text:p text:style-name="P99">* <text:span text:style-name="T94">pratico-pragm</text:span><text:span text:style-name="T95">a</text:span><text:span text:style-name="T94">tique </text:span><text:span text:style-name="T95">(travail communautaire, économies sur les licences et autres coûts?)</text:span></text:p>
-   <text:p text:style-name="P99">* <text:span text:style-name="T95">longévité (citer le rapport cour des comptes sur les logiciels en milieu médical)</text:span></text:p>
-   <text:p text:style-name="P99"><text:span text:style-name="T94">citer d’autres exemples que Pappso p</text:span><text:span text:style-name="T92">des </text:span>et <text:span text:style-name="T94">des </text:span>contrexemples <text:span text:style-name="T92">(inkscape, plantnet, Rijkmuseum, etc …)</text:span></text:p>
-   <text:p text:style-name="P99"><text:tab/>* <text:span text:style-name="T94">parler de œuvre culturelle libre</text:span></text:p>
-   <text:p text:style-name="Standard">* <text:span text:style-name="T94">avantages économiques ? </text:span><text:span text:style-name="T92">quelques mots sur les modèles économiques actuels du libre (au passage parler de la SAT)</text:span></text:p>
-   <text:p text:style-name="P95">* <text:span text:style-name="T92">idéologique : </text:span><text:span text:style-name="T95">bien commun + lutter contre la marchandisation de la recherche publique</text:span></text:p>
-   <text:h text:style-name="P87" text:outline-level="2"><text:soft-page-break/><text:span text:style-name="T28">Comment libérer ses logiciels / infrastructures en pratique ? </text:span></text:h>
-   <text:h text:style-name="P87" text:outline-level="2" text:is-list-header="true"><text:span text:style-name="T28">Etat actuel des recommandations et obligations officielles versus difficultés rencontrées</text:span></text:h>
+   <text:p text:style-name="P15">* <text:span text:style-name="T37">idéologique : </text:span><text:span text:style-name="T41">idée de contribution aux communs, revenir sur l’histoire et la fonction de la recherche publique, notion de liberté et d’éthique du travail public </text:span></text:p>
+   <text:p text:style-name="P15">Faire ici un aperçu de la situation d’enchâinement / privatrice de libertés dans laquelle on peut facilement se retrouver en recherche : instruments boites noires, formats de données fermés, specifications gardées secrètes, logiciels qu’on ne peut installer que sur un nombre limité de postes, aux formats non interopérables, </text:p>
+   <text:p text:style-name="P15"/>
+   <text:p text:style-name="P15">Parler de l’effet mode → attention aux vraies problématiques.</text:p>
+   <text:p text:style-name="P16">* <text:span text:style-name="T37">scientifique ;</text:span></text:p>
+   <text:p text:style-name="P17">% faire le liant dont parlait Filipo (plateforme parametrage, scientifique, apport …) avec l’exemple de Pappso (ex grouping en métoprotéomique) : on y arrive pas avec les logiciels commerciaux.</text:p>
+   <text:p text:style-name="P17">Agilité, de développement. </text:p>
+   <text:p text:style-name="P61">parler de la campagne public money public code, // avec l’édition libre et culture libre en général (interopérabilité, formats standards, <text:s/></text:p>
+   <text:p text:style-name="P16"><text:soft-page-break/>- tirer parti du travail déjà effectué, intégrer le code d’autres projets, intégration d’autres codes (Proteowizard, OpenMS etc) (copyleft un petit mot pour le défendre ici)</text:p>
+   <text:p text:style-name="P16">- retrouver le mail de l’INRA</text:p>
+   <text:p text:style-name="P16">- <text:span text:style-name="T37">pratico-pragmatique : la science / savoir est universelle (développer la dessus), parler de l’idéologie libre, politique.</text:span></text:p>
+   <text:p text:style-name="P16">- parler de public money, public code</text:p>
+   <text:h text:style-name="P52" text:outline-level="2"><text:span text:style-name="T8">Apport</text:span><text:span text:style-name="T9">s concrets</text:span></text:h>
+   <text:p text:style-name="P18">* <text:span text:style-name="T37">scientifique </text:span><text:span text:style-name="T38">(</text:span><text:span text:style-name="T47">PAPPSO</text:span><text:span text:style-name="T38"> ci dessus), R, Python, cf montrer que nos infrastructures, serveurs sous Linux, etc. </text:span></text:p>
+   <text:p text:style-name="P18"><text:a xlink:type="simple" xlink:href="https://mran.microsoft.com/documents/rro/multithread" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T38">https://mran.microsoft.com/documents/rro/multithread</text:span></text:a><text:span text:style-name="T38"> (microsoft qui fait son R)</text:span></text:p>
+   <text:p text:style-name="P13">* <text:span text:style-name="T39">sécurité informatique : logiciel libre, <text:s/></text:span><text:span text:style-name="T48">communauté</text:span><text:span text:style-name="T39">, auditable etc …</text:span></text:p>
+   <text:p text:style-name="P13">* ethique numérique : fait attention aux données personnelles, respect de la vie privée, respect RGPD etc. </text:p>
+   <text:p text:style-name="P13">* auto-formation, éducation : insister sur l’importance de la formation éducation aux concepts, au bidouillage, au mettre les mains à la pâte, (rebondir sur les concepts de diy, fab lab, etc qui au départ viennent de la communauté scientifique …), ne pas créer des dépendances à des outils et laisser se développer des attitudes qui n’aident pas le scientifique à avancer </text:p>
+   <text:p text:style-name="P13">* maîtrises ses données, ses outils etc.</text:p>
+   <text:p text:style-name="P26">* <text:span text:style-name="T39">travail communautaire</text:span></text:p>
+   <text:p text:style-name="P62">* apport financier : économies sur les licences et autres coûts?</text:p>
+   <text:p text:style-name="P20">* <text:span text:style-name="T39">longévité : car interopérabilité et formats standards (citer le rapport cour des comptes sur les logiciels en milieu médical)</text:span></text:p>
+   <text:p text:style-name="P20"><text:span text:style-name="T38">citer d’autres exemples que Pappso </text:span><text:span text:style-name="T37">des </text:span>et <text:span text:style-name="T38">des </text:span>contrexemples <text:span text:style-name="T37">(inkscape, plantnet, Rijkmuseum, etc …)</text:span></text:p>
+   <text:p text:style-name="P20">* <text:span text:style-name="T38">parler de œuvre culturelle libre</text:span></text:p>
+   <text:p text:style-name="Standard">* <text:span text:style-name="T38">avantages économiques ? </text:span><text:span text:style-name="T37">quelques mots sur les modèles économiques actuels du libre (au passage parler de la SAT)</text:span></text:p>
+   <text:p text:style-name="P14">* <text:span text:style-name="T37">idéologique : </text:span><text:span text:style-name="T39">bien commun + lutter contre la marchandisation de la recherche publique</text:span></text:p>
+   <text:h text:style-name="P50" text:outline-level="2">Comment libérer ses logiciels / infrastructures en pratique ? </text:h>
+   <text:h text:style-name="P50" text:outline-level="2">Etat actuel des recommandations et obligations officielles versus difficultés rencontrées</text:h>
    <text:p text:style-name="Standard">* Recommandations et obligations publiques actuelles</text:p>
-   <text:p text:style-name="P98"><text:tab/>* circulaire Eyraut</text:p>
-   <text:p text:style-name="P98"><text:tab/>* <text:span text:style-name="T92">Bothorel</text:span></text:p>
-   <text:p text:style-name="P98"><text:tab/>* <text:span text:style-name="T92">Etalab</text:span></text:p>
-   <text:p text:style-name="P92"><text:tab/>* SILL</text:p>
-   <text:p text:style-name="P101">versus</text:p>
-   <text:p text:style-name="P98">* Freins concrets / <text:span text:style-name="T93">réalité</text:span></text:p>
-   <text:p text:style-name="P98"><text:tab/>* <text:span text:style-name="T93">marchés fermés</text:span></text:p>
-   <text:p text:style-name="P98"><text:span text:style-name="T93">Et enfin </text:span>– comment les déjouer <text:span text:style-name="T93">et procéder en pratique ?</text:span></text:p>
-   <text:p text:style-name="P98"><text:s/><text:tab/>* <text:span text:style-name="T96">code.gouv.fr</text:span></text:p>
-   <text:p text:style-name="P98"><text:tab/>* https://communs.numerique.gouv.fr/</text:p>
-   <text:p text:style-name="P98"><text:tab/>* <text:span text:style-name="T96">Etalab, atelier</text:span><text:span text:style-name="T97">s </text:span><text:span text:style-name="T96"><text:s/>et gazette bluehats : https://communs.numerique.gouv.fr/bluehats/ateliers/</text:span></text:p>
-   <text:p text:style-name="P100">(Idée % de conclusion : privacy by default, security by design → libre parce que public, ou alors public money, public interest &amp; public code)</text:p>
+   <text:p text:style-name="P19"><text:tab/>* circulaire Ayraut : <office:annotation>
+     <dc:creator>Rusconi (Guest)</dc:creator>
+     <dc:date>2022-01-07T13:06:30.344861915</dc:date>
+     <text:p>tu veux dire Jean-Marc Ayrault, le premier ministre de FHollande ?</text:p>
+    </office:annotation></text:p>
+   <text:p text:style-name="P19"><text:tab/>* rapport <text:span text:style-name="T37">Bothorel : </text:span></text:p>
+   <text:p text:style-name="P19"><text:tab/>* <text:span text:style-name="T37">Etalab </text:span></text:p>
+   <text:p text:style-name="P27">* <text:span text:style-name="T40">code.gouv.fr</text:span></text:p>
+   <text:p text:style-name="P27"><text:tab/>* https://communs.numerique.gouv.fr/</text:p>
+   <text:p text:style-name="P27"><text:soft-page-break/><text:tab/>* <text:span text:style-name="T40">Etalab, atelier</text:span><text:span text:style-name="T41">s </text:span><text:span text:style-name="T40"><text:s/>et gazette bluehats : https://communs.numerique.gouv.fr/bluehats/ateliers/</text:span></text:p>
+   <text:p text:style-name="P12"><text:tab/>* SILL</text:p>
+   <text:p text:style-name="P28">mettre en place des infra publiques, insister pour que </text:p>
+   <text:p text:style-name="P28"/>
+   <text:p text:style-name="P28">Parler du fait que la recherche a été précurseur ds le domaine du bien commun, logiciel libre etc. Le monde economique utilise le logiciel libre, l’open source etc. Les GAFAM et entreprises se sont développés en gde partie, et de plus en plus sur des logiciels open source, c’est un terreau économique pour eux (faire tomber l’image du gd innovateur Steve Jobbs, Facebook etc), trouver un article qui parle de l’innovation </text:p>
+   <text:p text:style-name="P28">Parler de la SATT, <text:s/></text:p>
+   <text:p text:style-name="P21">(Idée % de conclusion : privacy by default, security by design → libre parce que public, ou alors public money, public interest &amp; public code)</text:p>
    <text:p text:style-name="Standard"/>
-   <text:p text:style-name="P102"><text:span text:style-name="T24"/></text:p>
-   <text:p text:style-name="P36"/>
-   <text:p text:style-name="P36"/>
+   <text:p text:style-name="P38"/>
+   <text:p text:style-name="P9"/>
+   <text:p text:style-name="P9"/>
    <text:p text:style-name="Titre_20_Bibliographie">Bibliographie</text:p>
-   <text:list xml:id="list3837479098" text:style-name="Numbering_20_4">
+   <text:list xml:id="list1534284587" text:style-name="Numbering_20_4">
     <text:list-item>
-     <text:p text:style-name="P74"><text:bookmark-start text:name="__RefNumPara__4219_4199412181"/>Rusconi F. Free Open Source Software for Protein and Peptide Mass Spectrometry- based Science. Curr Protein Pept Sci, 2 (22) 134-147, 2021 ; https://doi.org/10.2174/1389203722666210118160946<text:bookmark-end text:name="__RefNumPara__4219_4199412181"/></text:p>
+     <text:p text:style-name="P57"><text:bookmark-start text:name="__RefNumPara__4219_4199412181"/><text:span text:style-name="T42">Rusconi</text:span> F. Free Open Source Software for Protein and Peptide Mass Spectrometry- based Science. Curr Protein Pept Sci, 2 (22) 134-147, 2021 ; https://doi.org/10.2174/1389203722666210118160946<text:bookmark-end text:name="__RefNumPara__4219_4199412181"/></text:p>
     </text:list-item>
     <text:list-item>
-     <text:p text:style-name="P75"><text:bookmark-start text:name="__RefNumPara__4321_4199412181"/>Langella O. , Valot B., Jacob D., Balliau T., Flores R., Hoogland C., Joets J., Zivy M.. (2013) Management and dissemination of MS proteomic data with PROTICdb: Example of a quantitative comparison between methods of protein extraction. Proteomics, 9 (13) 1457-66<text:bookmark-end text:name="__RefNumPara__4321_4199412181"/></text:p>
+     <text:p text:style-name="P58"><text:bookmark-start text:name="__RefNumPara__4321_4199412181"/>Langella O. , Valot B., Jacob D., Balliau T., Flores R., Hoogland C., Joets J., Zivy M.. (2013) Management and dissemination of MS proteomic data with PROTICdb: Example of a quantitative comparison between methods of protein extraction. Proteomics, 9 (13) 1457-66<text:bookmark-end text:name="__RefNumPara__4321_4199412181"/></text:p>
     </text:list-item>
     <text:list-item>
-     <text:p text:style-name="P74"><text:bookmark-start text:name="__RefNumPara__4323_4199412181"/>Langella O, Rusconi F. mineXpert2: Full-Depth Visualization and Exploration of MSn Mass Spectrometry Data. J. Am. Soc. Mass Spectrom., 4 (32) 1138-114, mars 2021 ; https://doi.org/10.1021/jasms.0c00402<text:bookmark-end text:name="__RefNumPara__4323_4199412181"/></text:p>
+     <text:p text:style-name="P57"><text:bookmark-start text:name="__RefNumPara__4323_4199412181"/>Langella O, Rusconi F. mineXpert2: Full-Depth Visualization and Exploration of MSn Mass Spectrometry Data. J. Am. Soc. Mass Spectrom., 4 (32) 1138-114, mars 2021 ; https://doi.org/10.1021/jasms.0c00402<text:bookmark-end text:name="__RefNumPara__4323_4199412181"/></text:p>
     </text:list-item>
     <text:list-item>
-     <text:p text:style-name="P74"><text:bookmark-start text:name="__RefNumPara__4176_4199412181"/>Langella O, Valot B, Balliau T, Blein-Nicolas M, Bonhomme L, Zivy M. X!TandemPipeline: A Tool to Manage Sequence Redundancy for Protein Inference and Phosphosite Identification. J. Proteome Res., 2 (16) 494-503, décembre 2016 ; <text:a xlink:type="simple" xlink:href="https://doi.org/10.1021/acs.jproteome.6b00632" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://doi.org/10.1021/acs.jproteome.6b00632</text:a><text:bookmark-end text:name="__RefNumPara__4176_4199412181"/></text:p>
+     <text:p text:style-name="P57"><text:bookmark-start text:name="__RefNumPara__4176_4199412181"/>Langella O, Valot B, Balliau T, Blein-Nicolas M, Bonhomme L, Zivy M. X!TandemPipeline: A Tool to Manage Sequence Redundancy for Protein Inference and Phosphosite Identification. J. Proteome Res., 2 (16) 494-503, décembre 2016 ; <text:a xlink:type="simple" xlink:href="https://doi.org/10.1021/acs.jproteome.6b00632" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://doi.org/10.1021/acs.jproteome.6b00632</text:a><text:bookmark-end text:name="__RefNumPara__4176_4199412181"/></text:p>
     </text:list-item>
     <text:list-item>
-     <text:p text:style-name="P74"><text:bookmark-start text:name="__RefNumPara__4381_4199412181"/>Valot B, Langella O, Nano E, Zivy M. MassChroQ: a versatile tool for mass spectrometry quantification. Proteomics, 17 (11) 3572-3577, juin 2011 ; https://doi.org/10.1002/pmic.201100120<text:bookmark-end text:name="__RefNumPara__4381_4199412181"/></text:p>
+     <text:p text:style-name="P57"><text:bookmark-start text:name="__RefNumPara__4381_4199412181"/>Valot B, Langella O, Nano E, Zivy M. MassChroQ: a versatile tool for mass spectrometry quantification. Proteomics, 17 (11) 3572-3577, juin 2011 ; https://doi.org/10.1002/pmic.201100120<text:bookmark-end text:name="__RefNumPara__4381_4199412181"/></text:p>
     </text:list-item>
     <text:list-item>
-     <text:p text:style-name="P74"><text:bookmark-start text:name="__RefNumPara__4411_4199412181"/><text:soft-page-break/>Van Den Bossche T, Kunath BJ, Schallert K, Schäpe SS, Abraham PE, Armengaud J, Arntzen M, Bassignani A, Benndorf D, Fuchs S, Giannone RJ, Griffin TJ, Hagen LH, Halder R, Henry C, Hettich RL, Heyer R, Jagtap P, Jehmlich N, Jensen M, Juste C, Kleiner M, Langella O, Lehmann T, Leith E, May P, Mesuere B, Miotello G, Peters SL, Pible O, Queiros PT, Reichl U, Renard BY, Schiebenhoefer H, Sczyrba A, Tanca A, Trappe K, Trezzi JP, Uzzau S, Verschaffelt P, von Bergen M, Wilmes P, Wolf M, Martens L, Muth T. Critical Assessment of MetaProteome Investigation (CAMPI): a multi-laboratory comparison of established workflows. Nature <text:s/>Communiations, 1 (12) 7305, décembre 2021 ; https://doi.org/10.1038/s41467-021-27542-8<text:bookmark-end text:name="__RefNumPara__4411_4199412181"/></text:p>
+     <text:p text:style-name="P57"><text:bookmark-start text:name="__RefNumPara__4411_4199412181"/>Van Den Bossche T, Kunath BJ, Schallert K, Schäpe SS, Abraham PE, Armengaud J, Arntzen M, Bassignani A, Benndorf D, Fuchs S, Giannone RJ, Griffin TJ, Hagen LH, Halder R, Henry C, Hettich RL, Heyer R, Jagtap P, Jehmlich N, Jensen M, Juste C, Kleiner M, Langella O, Lehmann T, Leith E, May P, Mesuere B, Miotello G, Peters SL, Pible O, Queiros PT, Reichl U, Renard BY, Schiebenhoefer H, Sczyrba A, Tanca A, Trappe K, Trezzi JP, Uzzau S, Verschaffelt P, von Bergen M, Wilmes P, Wolf M, Martens L, Muth T. Critical Assessment of MetaProteome Investigation (CAMPI): a multi-laboratory comparison of established workflows. Nature <text:s/>Communiations, 1 (12) 7305, décembre 2021 ; https://doi.org/10.1038/s41467-021-27542-8<text:bookmark-end text:name="__RefNumPara__4411_4199412181"/></text:p>
     </text:list-item>
    </text:list>
   </office:text>