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       <dc:creator>Pascal AUBRY</dc:creator>
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       <dc:creator>Pascal AUBRY</dc:creator>
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   <text:p text:style-name="P3">Logiciels libres : à la recherche du bien commun</text:p>
   <text:p text:style-name="P45">Edlira Nano</text:p>
   <text:p text:style-name="Laboratoire"><text:change-start text:change-id="ct94327720134304"/><text:span text:style-name="T1"><office:annotation>
      <dc:creator>Pascal AUBRY</dc:creator>
      <dc:date>2022-02-03T06:01:07.937000000</dc:date>
      <meta:creator-initials>PA</meta:creator-initials>
      <text:p text:style-name="P87"><text:span text:style-name="T161">Styles Laboratoire/Adresse (pour tous)</text:span></text:p>
      <text:p text:style-name="P87"><text:span text:style-name="T161">Passage sur une ligne pour faire tenir le résumé sur la première page.</text:span></text:p>
     </office:annotation></text:span><text:change-end text:change-id="ct94327720134304"/><text:span text:style-name="T1">I</text:span>nformaticienne indépendante – <text:span text:style-name="T153">Associations April, La Quadrature Du Net </text:span></text:p>
   <text:p text:style-name="Adresse">eda@mutu.net / eda@laquadrature.net</text:p>
   <text:p text:style-name="P46">Olivier Langella</text:p>
   <text:p text:style-name="P69">Ingénieur au CNRS<text:change-start text:change-id="ct94327720130480"/> – <text:change-end text:change-id="ct94327720130480"/><text:change-start text:change-id="ct94327720134672"/></text:p>
   <text:p text:style-name="P69"><text:change-end text:change-id="ct94327720134672"/>Plateforme PAPPSO - Laboratoire GQE-Le Moulon</text:p>
   <text:p text:style-name="Adresse">Ferme du Moulon 91190 Gif-sur-Yvette France</text:p>
   <text:p text:style-name="Adresse">olivier.langella@universite-paris-saclay.fr</text:p>
   <text:p text:style-name="P54"/>
   <text:p text:style-name="P47"><text:span text:style-name="T31">Filippo</text:span><text:span text:style-name="T54"> </text:span><text:span text:style-name="T31">Rusconi</text:span></text:p>
   <text:p text:style-name="P70"><text:span text:style-name="T33">Chercheur au CNRS</text:span><text:change-start text:change-id="ct94327720120944"/><text:span text:style-name="T33"> – </text:span><text:change-end text:change-id="ct94327720120944"/><text:change-start text:change-id="ct94327720124944"/></text:p>
   <text:p text:style-name="P70"><text:change-end text:change-id="ct94327720124944"/>Plateforme <text:span text:style-name="T33">PAPPSO - </text:span>Laboratoire GQE-Le Moulon</text:p>
   <text:p text:style-name="Adresse">Ferme du Moulon 91190 Gif-sur-Yvette France</text:p>
   <text:p text:style-name="Adresse">filippo.rusconi@universite-paris-saclay.fr</text:p>
   <text:p text:style-name="Titre_20_résumé">Résumé</text:p>
   <text:p text:style-name="P51">Le logiciel libre et la recherche publique partagent un objectif : le bien commun, au service de tous. Cette présentation revient sur ce que sont le bien commun et la science ouverte pour essayer de les analyser à l&apos;aide de l&apos;exemple de la <text:span text:style-name="T1">P</text:span>lateforme scientifique Analyses <text:span text:style-name="T1">P</text:span>rotéomiques de Paris Sud-Ouest (PAPPSO).</text:p>
   <text:p text:style-name="P51">PAPPSO s&apos;est dotée d&apos;une infrastructure informatique complète basée exclusivement sur du <text:span text:style-name="T2">logiciel libre</text:span> : réseau, serveurs, stockage, calcul et postes personnels. Elle développe plusieurs logiciels<text:span text:style-name="T131"> scientifiques</text:span> sous licence libre, dont ceux qui forment la chaîne de traitement des données de spectrométrie de masse. Ce choix naturel facilite la reproductibilité des traitements, apporte la maîtrise des logiciels et permet l&apos;intégration de code source tiers<text:span text:style-name="T131"> eux-mêmes publiés sous licence libre</text:span>.</text:p>
   <text:p text:style-name="P53"><text:span text:style-name="T131">Historiquement, l</text:span>&apos;apport majeur du <text:span text:style-name="T2">logiciel libre</text:span> à la recherche publique <text:span text:style-name="T131">a </text:span><text:span text:style-name="T132">d&apos;abord </text:span><text:span text:style-name="T131">résidé dans la mise en place de systèmes informatiques complexes tirant au mieux parti des réseaux</text:span>. <text:span text:style-name="T132">Progressivement, le logiciel libre s&apos;est implanté avec force dans les laboratoires</text:span><text:span text:style-name="T133">. </text:span><text:span text:style-name="T24">En effet</text:span><text:span text:style-name="T133">,</text:span><text:span text:style-name="T132"> d</text:span><text:span text:style-name="T131">&apos;un point de vue s</text:span>cientifique, l&apos;ouverture du code source et l<text:span text:style-name="T132">es licences libres</text:span> garantissent <text:span text:style-name="T132">une plus grande </text:span><text:change-start text:change-id="ct94327720043664"/><text:span text:style-name="T132"><text:s/></text:span><text:change-end text:change-id="ct94327720043664"/>réutilisation <text:span text:style-name="T132">du code source et sa vérificat</text:span>ion par les pairs<text:span text:style-name="T132">; la science gagnait ainsi en fiabilité.</text:span> <text:span text:style-name="T132">Cet élan a débordé le cadre strict du code source des logiciels pour irriguer le secteur </text:span><text:span text:style-name="T23">stratégique</text:span><text:span text:style-name="T132"> des formats de fichier. C&apos;est bien le monde du logiciel libre qui a contraint les éditeurs de logiciels à ouvrir les formats de leurs fichiers, jusqu&apos;alors conservés secrets comme </text:span><text:span text:style-name="T98">« </text:span><text:span text:style-name="T132">arme</text:span><text:span text:style-name="T98"> »</text:span><text:span text:style-name="T132"> commerciale redoutable. </text:span><text:span text:style-name="T133">De manière intéressante, l&apos;impact a été encore plus profond, avec la prise de conscience que les données aussi devaient être ouvertes. </text:span><text:span text:style-name="T132">Code source libre</text:span><text:span text:style-name="T133">,</text:span><text:span text:style-name="T132"> formats ouverts </text:span><text:span text:style-name="T133">et données publiques </text:span><text:span text:style-name="T132">forment un bien commun qui est</text:span> protégé par des licences. De nombreux laboratoires y contribuent en utilisant ou en produisant des logiciels libres, <text:span text:style-name="T133">ou encore en publiant les données en accès libre, </text:span>comme en témoigne<text:span text:style-name="T133">nt</text:span> la forge du code source du secteur public (<text:a xlink:type="simple" xlink:href="https://code.gouv.fr/" office:target-frame-name="_blank" xlink:show="new" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://code.gouv.fr</text:a>)<text:span text:style-name="T133"> et les actions ministérielles spécifiques (</text:span><text:a xlink:type="simple" xlink:href="https://www.ouvrirlascience.fr/college-donnees-de-la-recherche/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T133">https://www.ouvrirlascience.fr</text:span></text:a><text:span text:style-name="T133">).</text:span></text:p>
   <text:p text:style-name="P52">Comment contribuer efficacement<text:change-start text:change-id="ct94327720054032"/> <text:change-end text:change-id="ct94327720054032"/><text:change-start text:change-id="ct94327720203760"/> <text:change-end text:change-id="ct94327720203760"/>? Quelles sont les recommandations et obligations pour les établissements publics<text:change-start text:change-id="ct94327720204000"/> <text:change-end text:change-id="ct94327720204000"/><text:change-start text:change-id="ct94327720204240"/> <text:change-end text:change-id="ct94327720204240"/>? Quelle licence choisir<text:change-start text:change-id="ct94327720204480"/> <text:change-end text:change-id="ct94327720204480"/><text:change-start text:change-id="ct94327720204720"/> <text:change-end text:change-id="ct94327720204720"/>? Comment une licence <text:span text:style-name="T128">copyleft</text:span> peut-elle aussi séduire les partenaires privés<text:change-start text:change-id="ct94327720205312"/> <text:change-end text:change-id="ct94327720205312"/><text:change-start text:change-id="ct94327720205552"/> <text:change-end text:change-id="ct94327720205552"/>? Nous apporterons des réponses et des éléments de réflexion pour <text:soft-page-break/>corriger quelques fausses croyances et promouvoir la construction collective d&apos;une culture libre, au service du bien commun.</text:p>
   <text:p text:style-name="P57">Mots-clefs</text:p>
   <text:p text:style-name="P58"><text:change-start text:change-id="ct94327720207200"/><text:span text:style-name="T95">l</text:span><text:change-end text:change-id="ct94327720207200"/><text:change-start text:change-id="ct94327720207440"/><text:span text:style-name="T152">L</text:span><text:change-end text:change-id="ct94327720207440"/><text:span text:style-name="T95">ogiciel libre, </text:span><text:span text:style-name="T37">logiciel scientifique, biens communs, science ouverte, </text:span><text:span text:style-name="T45">open source</text:span><text:span text:style-name="T122">, </text:span><text:change-start text:change-id="ct94327720207680"/><text:span text:style-name="T129">copyleft</text:span><text:change-end text:change-id="ct94327720207680"/><text:span text:style-name="T95">, protéomique, infrastructure</text:span></text:p>
   <text:h text:style-name="Heading_20_1" text:outline-level="1">Une p<text:span text:style-name="T25">lateforme pour la recherche sous logiciel libre</text:span></text:h>
   <text:h text:style-name="Heading_20_2" text:outline-level="2">Contexte scientifique</text:h>
   <text:p text:style-name="P5"><text:span text:style-name="T98">La </text:span><text:span text:style-name="T38">protéomique</text:span><text:span text:style-name="T98"> est l’étude de l’ensemble des protéines produites par une cellule, un organe ou un organisme. Elle permet d’analyser sans </text:span><text:span text:style-name="T101">a priori</text:span><text:span text:style-name="T98"> les changements qualitatifs ou quantitatifs dans la composition en protéines en fonction de traitements, du développement ou de variations génétiques, et de comprendre par exemple comment un organisme répond à un stress ou à une maladie.</text:span></text:p>
   <text:p text:style-name="P24">L’apparition du terme « protéomique » en 1995 coïncide avec le début de l’utilisation de la spectrométrie de masse pour l’identification des protéines puis pour leur quantification. Aujourd’hui la méthode utilisée quasi exclusivement est l’analyse de peptides issus de la digestion <text:span text:style-name="T102">triptyque</text:span> des protéines, par un spectromètre de masse couplé à une chaîne de chromatographie liquide. Les appareils n’ont pas cessé d’évoluer mais au final il s’agit toujours de mesurer la masse moléculaire des peptides ayant pénétré dans le spectromètre et/ou de leurs fragments et de quantifier leur intensité.</text:p>
   <text:p text:style-name="P19"><text:span text:style-name="T33">Les analyses </text:span><text:span text:style-name="T34">par</text:span><text:span text:style-name="T33"> spectrométrie de masse produisent de grande</text:span><text:span text:style-name="T34">s</text:span><text:span text:style-name="T33"> quan</text:span>tité<text:span text:style-name="T54">s</text:span> de données, <text:span text:style-name="T54">directement en sortie de l&apos;instrument. Chaque fabricant a son propre format de données, qui est le plus souvent propriétaire.</text:span> <text:span text:style-name="T54">Ordinairement, les données aux formats propriétaires sont traitées par les logiciels fournis avec l&apos;instrument, eux aussi propriétaires. Comme souvent dans le domaine des formats de fichiers, c</text:span>es formats ne sont pas pérennes<text:span text:style-name="T54"> et les licences d&apos;utilisation des logiciels propriétaires sont très coûteuses</text:span>. <text:span text:style-name="T54">Il y a donc ici un problème majeur d&apos;interopérabilité.</text:span></text:p>
   <text:p text:style-name="P32">Depuis 2005, la plateforme scientifique « Analyses protéomiques de Paris Sud-Ouest » (PAPPSO) a fait le choix du logiciel libre pour garantir la pérennité de ses chaînes de traitement, la reproductibilité des expériences et la capitalisation de son savoir-faire.</text:p>
   <text:h text:style-name="P42" text:outline-level="2"><text:span text:style-name="T30">Transition d</text:span><text:span text:style-name="T29">es</text:span><text:span text:style-name="T30"> logiciel</text:span><text:span text:style-name="T29">s</text:span><text:span text:style-name="T30"> propriétaire</text:span><text:span text:style-name="T29">s</text:span><text:span text:style-name="T30"> au </text:span><text:span text:style-name="T29">logiciel libre</text:span></text:h>
   <text:p text:style-name="P5"><text:span text:style-name="T51">Le passage progressif au </text:span><text:span text:style-name="T34">logiciel libre</text:span><text:span text:style-name="T51"> a permis une rationalisation de l’utilisation des ressources informatiques. Nous sommes passés de postes dédiés à licence unique pour usage unique à une infrastructure collective combinant stockage, calcul et enchaînement des traitements depuis n’importe quel poste de travail.</text:span></text:p>
   <text:p text:style-name="P5"><text:span text:style-name="T52">Durant la période 2005–2015, notre travail a été facilité par la définition de formats standards en protéomique, l’émergence de nombreux logiciels libres dans le domaine </text:span><text:span text:style-name="T52"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4219_4199412181">[1]</text:bookmark-ref></text:span><text:span text:style-name="T52"> et le développement de nouvelles solutions logicielles sous licence libre (PROTICdb </text:span><text:span text:style-name="T52"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4321_4199412181">[2]</text:bookmark-ref></text:span><text:span text:style-name="T52">, mineXpert2 </text:span><text:span text:style-name="T52"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4323_4199412181">[3]</text:bookmark-ref></text:span><text:span text:style-name="T52">, X!TandemPipeline </text:span><text:span text:style-name="T52"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4176_4199412181">[4]</text:bookmark-ref></text:span><text:span text:style-name="T52">, MassChroQ </text:span><text:span text:style-name="T52"><text:bookmark-ref text:reference-format="number-all-superior" text:ref-name="__RefNumPara__2718_4175847089">[5]</text:bookmark-ref></text:span><text:span text:style-name="T52">).</text:span><text:change-start text:change-id="ct94327720178672"/><text:span text:style-name="T52"><text:tab/></text:span><text:change-end text:change-id="ct94327720178672"/></text:p>
   <text:h text:style-name="P35" text:outline-level="2"><text:span text:style-name="T54">Choix du s</text:span>ystème<text:span text:style-name="T54"> d’exploitation</text:span></text:h>
   <text:p text:style-name="P33"><text:span text:style-name="T53">Le choix de PAPPSO</text:span><text:span text:style-name="T52"><text:note text:id="ftn1" text:note-class="footnote"><text:note-citation>1</text:note-citation><text:note-body>
       <text:p text:style-name="Footnote">http://pappso.inrae.fr/</text:p></text:note-body></text:note></text:span><text:span text:style-name="T53"> s’est porté d’abord sur la distribution GNU/Linux Ubuntu, puis sur Debian. Un groupe de développeurs officiels Debian, dont un auteur de ce rapport, s&apos;attache à fournir dans la </text:span><text:soft-page-break/><text:span text:style-name="T53">distribution de nombreux logiciels pour la chimie, et en particulier pour la spectrométrie de masse (</text:span><text:span text:style-name="T4">team debichem</text:span><text:span text:style-name="T54">). L&apos;intérêt principal de la distribution Debian est la richesse de son offre logicielle qui permet de disposer d&apos;un socle de fonctionnalités robuste couvrant les exigences « serveur » et les impératifs « bureautique ». Tous les logiciels développés par PAPPSO sont disponibles sous forme de paquets Debian dans des dépôts publics. Le déploiement des logiciels, dépendances comprises, sur les serveurs et les postes de travail de l’équipe est ainsi simplifié et totalement automatisé.</text:span></text:p>
   <text:h text:style-name="P44" text:outline-level="2"><text:span text:style-name="T30">S</text:span><text:span text:style-name="T28">tockage des données</text:span></text:h>
   <text:p text:style-name="P20">Les besoins en stockage de la plateforme évoluent constamment en fonction des progrès techniques des spectromètres de masse. <text:span text:style-name="T55">Chaque nouvelle génération d&apos;instruments apporte des améliorations, en particulier sur la précision de mesure de masse, qui provoquent une augmentation significative du volume des données générées.</text:span> Cette progression des besoins en volume de stockage sur les quinze dernières années est illustrée dans la figure ci-dessous.</text:p>
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   <text:p text:style-name="P21"><text:span text:style-name="T32">Figure </text:span><text:sequence text:ref-name="refFigure0" text:name="Figure" text:formula="ooow:Figure+1" style:num-format="1">1</text:sequence><text:s/>– <text:span text:style-name="T100">É</text:span><text:span text:style-name="T99">volution</text:span><text:span text:style-name="T18"> des besoins de stockage de la plateforme en To/an, </text:span><text:span text:style-name="T19">en relation avec la production des données par les générations d&apos;instruments</text:span></text:p>
   <text:p text:style-name="P20">Le système de stockage <text:span text:style-name="T55">des données de spectrométrie de masse </text:span>doit permettre une adaptation en continu de l<text:span text:style-name="T55">a</text:span> volumétrie <text:span text:style-name="T55">d&apos;espace disque </text:span>disponible ainsi que <text:span text:style-name="T55">l</text:span>es <text:span text:style-name="T55">meilleures </text:span>performances en lecture<text:span text:style-name="T55"> et </text:span>écriture. Les solutions classiques de type NAS ont été écartées pour éviter la dépendance matérielle et les problèmes liés au renouvellement des équipements.</text:p>
   <text:p text:style-name="P6">Dès 2011, nous avons été parmi les premiers à faire confiance à une solution nouvelle de stockage distribué : Ceph<text:note text:id="ftn2" text:note-class="footnote"><text:note-citation>2</text:note-citation><text:note-body>
      <text:p text:style-name="P55">https://ceph.io/</text:p></text:note-body></text:note>. La principale caractéristique de ce système de stockage est de ne requérir que des serveurs standard. La flexibilité et l&apos;adaptabilité de ce système à des besoins perpétuellement en évolution en ont fait<text:span text:style-name="T54"> </text:span>la solution la plus robuste que nous connaissions.</text:p>
   <text:h text:style-name="P36" text:outline-level="2">Calcul scientifique</text:h>
   <text:p text:style-name="P22">La plateforme PAPPSO est <text:span text:style-name="T33">spécialisée</text:span> dans les traitements en protéomique haut débit (nombreux échantillons<text:span text:style-name="T55"> à traiter dans les plus brefs délais</text:span>). Pour assurer la disponibilité de nos moyens de calcul à l’ensemble des utilisateurs, nous utilisons le gestionnaire de processus HTCondor<text:note text:id="ftn3" text:note-class="footnote"><text:note-citation>3</text:note-citation><text:note-body>
      <text:p text:style-name="Footnote">https://htcondor.org/</text:p></text:note-body></text:note>.</text:p>
   <text:p text:style-name="P22"><text:soft-page-break/>Les besoins en calcul évoluent eux aussi en fonction des instruments utilisés. Avec l<text:span text:style-name="T33">’évolution des techniques, de nouvelles possibilités sont apparues dans le traitement de données en</text:span> protéomique, exigeant elles aussi des capacités de calcul supplémentaires. De la même manière que pour les capacités de stockage, les machines dédiées au calcul doivent être ainsi renouvelées régulièrement et intégrées au fur et à mesure.</text:p>
   <text:h text:style-name="P48" text:outline-level="1">Retour d’expérience sur 10 <text:span text:style-name="T97">ans</text:span></text:h>
   <text:h text:style-name="P37" text:outline-level="2">Matériel</text:h>
   <text:p text:style-name="P23">L’<text:span text:style-name="T96">intégration de nouvelles machines de calcul ou de stockage s’est faite de manière transparente. Nous sommes passés d’une capacité de stockage initiale de 18 To (3 serveurs R515, disques de 3 To) en 2011 à une capacité de 917 To (8 serveurs hétérogènes). Le réseau est passé du 1 Gb cuivre au 10 Gb SFP+. Il n’y a pas eu de transfert de données/migration, pas de modification de l’architecture logique pour les utilisateurs. Le système de fichiers </text:span><text:span text:style-name="T6">cephfs</text:span><text:span text:style-name="T96"> permet un accès direct aux données depuis chaque nœud de calcul. Globalement, les performances ont suivi les évolutions matérielles (augmentation du débit, augmentation des capacités de calcul). La résistance aux pannes a été mise à rude épreuve (panne électrique, disques ou erreurs humaines) et nous n’avons jamais eu de perte de données.</text:span></text:p>
   <text:h text:style-name="P38" text:outline-level="2">Logiciel</text:h>
   <text:p text:style-name="P7">Les systèmes <text:span text:style-name="T55">pour les </text:span>serveurs et <text:span text:style-name="T55">pour les postes </text:span>utilisateurs ont été migrés en 2013 de Ubuntu GNU/Linux vers Debian. Nous y avons gagné en stabilité et en simplicité lors des mises à jour de version. <text:span text:style-name="T55">La stratégie consiste à maintenir le parc informatique sous Debian « stable » et effectuer le passage à la version successive dans les mois qui suivent sa publication officielle. </text:span>Le stockage centralisé est disponible pour tous les postes dans une arborescence commune,<text:span text:style-name="T55"> via un</text:span> montage automatique sur les nœuds de calculs (<text:span text:style-name="T3">cephfs</text:span> via <text:span text:style-name="T3">systemd</text:span> sur les serveurs, <text:span text:style-name="T3">sshfs</text:span> sur les postes clients). Les logiciels sont les mêmes sur les serveurs et les postes utilisateurs. L’accès distant au cluster de calcul se fait avec <text:span text:style-name="T3">x2go</text:span>, via <text:span text:style-name="T55">une </text:span>clé publique <text:span text:style-name="T130">SSH</text:span>.</text:p>
   <text:h text:style-name="P39" text:outline-level="2">Scientifique</text:h>
   <text:p text:style-name="P5"><text:span text:style-name="T56">Les analyses de la plateforme ont évolué pour passer de la technique </text:span><text:span text:style-name="T134">chronophage </text:span><text:span text:style-name="T56">des gels d’électrophorèse 2D</text:span><text:note text:id="ftn4" text:note-class="footnote"><text:note-citation>4</text:note-citation><text:note-body>
      <text:p text:style-name="P56">Technique visant à séparer les nombreuses protéines d&apos;un échantillon complexe en fonction de leur poids moléculaire, dans l&apos;épaisseur d&apos;un feuillet qui agit comme un tamis moléculaire.</text:p></text:note-body></text:note><text:span text:style-name="T56"> vers des analyses uniquement basées sur la spectrométrie de masse. Le traitement des images des gels 2D était majoritairement effectué avec des logiciels propriétaires sous Windows, sur des postes dédiés, ce qui limitait les capacités de traitement. Le passage progressif à des processus analytiques qui faisaient l&apos;économie de l&apos;étape d&apos;électrophorèse a coïncidé avec les apports massifs du logiciel libre dans le domaine scientifique, au milieu des années 2000. Nous avons alors pu commencer la transition vers certains logiciels libres qui émergeaient à cette époque. Cependant, ces logiciels étaient principalement des </text:span><text:span text:style-name="T135">bibliothèques partagées</text:span><text:span text:style-name="T56"> encore imparfaitement dotées des fonctionnalités requises dans notre domaine. Nous avons alors entrepris le développement de nos logiciels sur la base des besoins scientifiques particuliers à notre plateforme. Le logiciel MassChroQ est né ainsi, de nos besoins en protéomique quantitative. Notre indépendance vis-à-vis des formats de données propriétaires des fabricants nous a permis de produire un logiciel évolutif et pérenne dès le départ, évitant l’effet « boîte noire ». Ainsi, notre offre logicielle a pu être adaptée au fur et à mesure aux nouvelles techniques, à des instruments significativement différents de génération en génération, absorbant ainsi les « chocs » </text:span><text:soft-page-break/><text:span text:style-name="T56">technologiques : doublement des fréquences d’acquisition à chaque génération (3 ans), doublement du pouvoir résolutif (précision des mesures des masses).</text:span></text:p>
   <text:p text:style-name="P5"><text:span text:style-name="T57">La dernière « rupture technologique » a été l’apparition du </text:span><text:span text:style-name="T7">tim</text:span><text:span text:style-name="T8">s</text:span><text:span text:style-name="T7">TOF </text:span><text:span text:style-name="T9">P</text:span><text:span text:style-name="T7">ro</text:span><text:span text:style-name="T57"> du fabricant Bruker. Cet appareil dispose d’une fréquence d’acquisition 10 fois supérieure à celle de la génération précédente ainsi que d’une nouvelle dimension de séparation des peptides (mobilité ionique). Fait unique depuis les débuts de la protéomique, Bruker nous a confié les spécifications techniques de son format de fichier de données. Cela nous a permis d’adapter MassChroQ pour pouvoir utiliser de manière native les données obtenues sur cet instrument. Notre savoir-faire en développement C++ nous a ainsi permis d’obtenir des gains de performances remarquables par rapport aux logiciels commerciaux, ainsi que de meilleurs résultats scientifiques.</text:span></text:p>
   <text:h text:style-name="P49" text:outline-level="1">Importance d<text:span text:style-name="T123">e la culture l</text:span>ibre dans la recherche scientifique</text:h>
   <text:h text:style-name="Heading_20_2" text:outline-level="2"><text:span text:style-name="T123">C</text:span>ulture libre, communs et recherche publique</text:h>
   <text:p text:style-name="P8">La recherche publique vise à produire et à développer des connaissances, <text:span text:style-name="T135">à </text:span>les améliorer sans cesse, puis <text:span text:style-name="T135">à </text:span><text:span text:style-name="T136">les </text:span><text:span text:style-name="T135">rendre disponibles à la société</text:span>, <text:span text:style-name="T135">au cours</text:span> <text:span text:style-name="T135">d</text:span>es générations, constituant ainsi un <text:span text:style-name="T135">corpus de </text:span>savoir<text:span text:style-name="T135">s</text:span> qui caractérisent notre civilisation. La recherche scientifique est par essence incrémentale, <text:span text:style-name="T108">elle se nourrit du savoir établi, pour venir à son tour nourrir cet ensemble commun de savoirs.</text:span> Pour ce faire, <text:span text:style-name="T108">elle a besoin d’accéder aux connaissances établies sans entrave, puis de pouvoir à son tour faire l’objet d’une diffusion libre.</text:span></text:p>
   <text:p text:style-name="P8"><text:span text:style-name="T103">Nous</text:span> av<text:span text:style-name="T103">ons</text:span> là <text:span text:style-name="T137">les caractéristiques </text:span>d’un logiciel libre ou<text:span text:style-name="T137">,</text:span> plus largement<text:span text:style-name="T137">,</text:span> d’un bien libre : quelque chose qu’on peut utiliser librement, distribuer librement autour de nous, mais aussi en modifier le contenu, <text:span text:style-name="T137">pour </text:span>l’adapter<text:span text:style-name="T137"> ou</text:span> l’améliorer, pour ensuite le redistribuer<text:span text:style-name="T137"> tout aussi librement</text:span>. L<text:span text:style-name="T33">a</text:span> culture du libre n’est pas unique aux logiciels. Elle peut concerner <text:span text:style-name="T137">du</text:span> <text:span text:style-name="T109">code source, un algorithme, un </text:span>service informatique en ligne, un document (article scientifique, livre, poème)<text:span text:style-name="T137">,</text:span> un produit artistique (œuvre numérique, reproduction numérique d’une œuvre <text:span text:style-name="T123">physique </text:span>d’un musée, photo <text:span text:style-name="T123">numérique</text:span> d<text:span text:style-name="T137">&apos;un</text:span> monument <text:span text:style-name="T123">historique</text:span>), une semence agricole (les graines libres de droit), un médicament<text:span text:style-name="T137"> ou un vaccin</text:span> <text:span text:style-name="T103">qu</text:span><text:span text:style-name="T137">e l</text:span><text:span text:style-name="T103">’on peut fabriquer </text:span>libre<text:span text:style-name="T103">ment (</text:span><text:span text:style-name="T138">libre de</text:span><text:span text:style-name="T103"> brevet</text:span><text:span text:style-name="T123">)</text:span>.</text:p>
   <text:p text:style-name="P9">Cette culture du libre est inhérente à la recherche publique également, et plus largement à ce qu’on appelle les communs. Les communs sont des ressources, naturelles ou culturelles, partagées et gérées collectivement, accessibles et disponibles pour tous, et qui n’appartiennent pas à qui que ce soit au sens de la propriété, qu’elle soit publique ou privée <text:span text:style-name="T33">(Elinor Ostrom, prix</text:span><text:span text:style-name="T35"> </text:span><text:span text:style-name="T33">Nobel </text:span><text:span text:style-name="T35">d’</text:span><text:span text:style-name="T33">économie pour ses travaux sur l</text:span><text:span text:style-name="T40">es </text:span><text:span text:style-name="T33">communs, parle par exemple de « ressources de propriété commune » </text:span><text:span text:style-name="T33"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__1061291_151231740">[6]</text:bookmark-ref></text:span><text:span text:style-name="T33">).</text:span></text:p>
   <text:p text:style-name="P9"><text:span text:style-name="T39">La recherche publique, </text:span><text:span text:style-name="T35">en ce qu’elle </text:span><text:span text:style-name="T39">vise à améliorer, </text:span><text:span text:style-name="T35">à </text:span><text:span text:style-name="T39">rendre accessibles et disponibles</text:span><text:span text:style-name="T35"> </text:span><text:span text:style-name="T39">les savoirs </text:span><text:span text:style-name="T35">communs</text:span><text:span text:style-name="T39">, </text:span><text:span text:style-name="T35">peut ainsi ê</text:span><text:span text:style-name="T36">tre vue comme un processus cumulatif et collectif dont les résultats constituent un « bien commun » </text:span><text:span text:style-name="T36"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__126661_151231740">[7]</text:bookmark-ref></text:span><text:span text:style-name="T36"> .</text:span></text:p>
   <text:h text:style-name="Heading_20_2" text:outline-level="2">Vers une science ouverte</text:h>
   <text:p text:style-name="P10">La recherche publique en France <text:span text:style-name="T123">(voir Figure ci-dessous, sources 2018)</text:span> est financée à 75 % par des fonds publics français (MIRES, hors MIRES, <text:span text:style-name="T123">a</text:span>dministrations), et parmi les 25 % restants on ne retrouve que 5 % de ressources contractuelles provenant d’entreprises, les autres 20 % sont un mélange de fonds publics étrangers, notamment européens, ressources propres tels que les prestations de services des structures de recherche elle<text:span text:style-name="T139">s</text:span>-même<text:span text:style-name="T126">s</text:span>, et enfin des ressources privées<text:span text:style-name="T139"> provenant </text:span>d’entreprises étrangères) <text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__2284_944871799">[8]</text:bookmark-ref>.</text:p>
   <text:p text:style-name="P13"><text:span text:style-name="T139">En dépit de la très faible proportion de financements privés, </text:span><text:span text:style-name="T58">la recherche publique fait face à </text:span><text:span text:style-name="T139">la</text:span><text:span text:style-name="T58"> mise en place progressive de mécanismes de privatisation et de verrouillage de </text:span><text:span text:style-name="T139">ses </text:span><text:span text:style-name="T58">productions par des acteurs privés de plus en plus envahissants, </text:span><text:span text:style-name="T139">malheureusement </text:span><text:span text:style-name="T58">soutenus par des politiques publiques </text:span><text:change-start text:change-id="ct94327720191888"/><text:span text:style-name="T58"><text:s/></text:span><text:change-end text:change-id="ct94327720191888"/><text:soft-page-break/><text:span text:style-name="T58">de plus en plus</text:span><text:span text:style-name="T139"> </text:span><text:span text:style-name="T58">tournées vers les transferts de technologies à tout prix et la </text:span><text:span text:style-name="T139">valorisation, de type </text:span><text:span text:style-name="T58">brevet</text:span><text:span text:style-name="T139"> entre autres</text:span><text:span text:style-name="T58">. </text:span><text:span text:style-name="T139">Une autre difficulté est liée au </text:span><text:span text:style-name="T58">financement </text:span><text:span text:style-name="T139">sur projet </text:span><text:span text:style-name="T58">de la recherche </text:span><text:span text:style-name="T139">publique</text:span><text:span text:style-name="T58">, </text:span><text:span text:style-name="T139">à </text:span><text:span text:style-name="T58">un niveau insuffisant d</text:span><text:span text:style-name="T139">u</text:span><text:span text:style-name="T58"> financement public face à l’augmentation du nombre d’étudiants, </text:span><text:span text:style-name="T139">au</text:span><text:span text:style-name="T58"> recours massif à des contrats temporaires,</text:span><text:span text:style-name="T139"> qui</text:span><text:span text:style-name="T58"> perturbent grandement son fonctionnement</text:span><text:span text:style-name="T139"> (voir </text:span><text:span text:style-name="T58">le </text:span><text:span text:style-name="T139">rapport 2019 du </text:span><text:span text:style-name="T58">Comité national </text:span><text:span text:style-name="T139">du CNRS</text:span><text:span text:style-name="T58"> </text:span><text:span text:style-name="T58"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__1183515_151231740">[9]</text:bookmark-ref></text:span><text:span text:style-name="T139">,</text:span><text:span text:style-name="T58"> qui souhaite « un soutien public mû par la volonté de faire progresser les connaissances ».</text:span></text:p>
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     </draw:image>
    </draw:frame><text:span text:style-name="T20">Figure </text:span><text:span text:style-name="T20"><text:sequence text:ref-name="refFigure1" text:name="Figure" text:formula="ooow:Figure+1" style:num-format="1">2</text:sequence></text:span><text:span text:style-name="T20"><text:s/>– </text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T20">Nature des ressources de la recherche publique en 2018 (en %)</text:span></text:span><text:change-start text:change-id="ct94327731166528"/><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T20"><office:annotation>
       <dc:creator>Pascal AUBRY</dc:creator>
       <dc:date>2022-02-03T05:54:56.784000000</dc:date>
       <meta:creator-initials>PA</meta:creator-initials>
       <text:p text:style-name="P87"><text:span text:style-name="T161">Centrer l’image ?</text:span></text:p>
      </office:annotation></text:span></text:span><text:change-end text:change-id="ct94327731166528"/></text:p>
   <text:p text:style-name="P26"/>
   <text:p text:style-name="P14"><text:span text:style-name="T60">La</text:span><text:span text:style-name="T71"> culture libre, au service du savoir commun, que la recherche publique incarne </text:span><text:span text:style-name="T72">et qui la structure</text:span><text:span text:style-name="T71">, </text:span><text:span text:style-name="T78">est illustrée</text:span><text:span text:style-name="T60"> par l</text:span><text:span text:style-name="T73">es </text:span><text:span text:style-name="T60">nombreux</text:span><text:span text:style-name="T73"> mouvements </text:span><text:span text:style-name="T60">pour une science ouverte, mouvements</text:span><text:span text:style-name="T111"> qui ont souvent vu le jour au sein des organismes de recherche. Ce sont des chercheurs, des étudiants ou des bibliothécaires, confrontés sans doute à cette nécessité d’ouverture, qui œuvrent, parfois leur vie durant, pour faire avancer l’ouverture des productions scientifiques. Ce n’est qu’après ces premières impulsions venant du terrain, qu’on voit s’opérer petit à petit une institutionnalisation progressive de cette ouverture.</text:span></text:p>
   <text:p text:style-name="P14"><text:span text:style-name="T81">Ainsi le mouvement de l’« </text:span><text:span text:style-name="T10">open access </text:span><text:span text:style-name="T82">» en est un bel exemple. ArXiv</text:span><text:span text:style-name="T82"><text:note text:id="ftn5" text:note-class="footnote"><text:note-citation>5</text:note-citation><text:note-body>
       <text:p text:style-name="Footnote">https://fr.wikipedia.org/wiki/ArXiv</text:p></text:note-body></text:note></text:span><text:span text:style-name="T82"> a été l&apos;une des premières archives ouvertes de publications scientifiques, créée dès 1991 par le physicien Paul Ginsparg</text:span><text:change-start text:change-id="ct94327731223248"/><text:span text:style-name="T82"> </text:span><text:change-end text:change-id="ct94327731223248"/><text:change-start text:change-id="ct94327731216096"/><text:span text:style-name="T82"> </text:span><text:change-end text:change-id="ct94327731216096"/><text:span text:style-name="T82">et maintenue par des laboratoires de recherche. L’équivalent français de ArXiv, HAL</text:span><text:span text:style-name="T82"><text:note text:id="ftn6" text:note-class="footnote"><text:note-citation>6</text:note-citation><text:note-body>
       <text:p text:style-name="Footnote">https://fr.wikipedia.org/wiki/HAL_(archive_ouverte)</text:p></text:note-body></text:note></text:span><text:span text:style-name="T82">, </text:span><text:span text:style-name="T140">a été</text:span><text:span text:style-name="T82"> créé en 2001 par des chercheurs et s’</text:span><text:span text:style-name="T140">est </text:span><text:span text:style-name="T82">institutionnalis</text:span><text:span text:style-name="T140">é</text:span><text:span text:style-name="T82"> </text:span><text:span text:style-name="T140">au cours des années suivantes</text:span><text:span text:style-name="T82">. Avant HAL, les travaux précurseurs de la bibliothécaire de l’INRA Hélène Bosc sont également remarquables </text:span><text:span text:style-name="T82"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__313535_151231740">[10]</text:bookmark-ref></text:span><text:span text:style-name="T82">. Témoignant de l’institutionnalisation progressive de la démarche, la plateforme de publications ouvertes orientée sciences humaines et sociales Open Edition</text:span><text:span text:style-name="T82"><text:note text:id="ftn7" text:note-class="footnote"><text:note-citation>7</text:note-citation><text:note-body>
       <text:p text:style-name="Footnote"><text:a xlink:type="simple" xlink:href="https://www.openedition.org/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T140">https://www.openedition.org/</text:span></text:a></text:p></text:note-body></text:note></text:span><text:span text:style-name="T82"> </text:span><text:span text:style-name="T140">a vu</text:span><text:span text:style-name="T82">, elle, le jour en 2011 en France. </text:span></text:p>
   <text:p text:style-name="P30"><text:span text:style-name="T113">Du côté des </text:span><text:span text:style-name="T140">ha</text:span><text:span text:style-name="T113">c</text:span><text:span text:style-name="T140">k</text:span><text:span text:style-name="T113">tivistes, en cette même année 2011, naissait le projet de captation et de diffusion d’articles scientifiques Sci-Hub</text:span><text:span text:style-name="T113"><text:note text:id="ftn8" text:note-class="footnote"><text:note-citation>8</text:note-citation><text:note-body>
       <text:p text:style-name="Footnote">https://fr.wikipedia.org/wiki/Sci-Hub</text:p></text:note-body></text:note></text:span><text:span text:style-name="T113">. Initié par </text:span><text:a xlink:type="simple" xlink:href="https://fr.wikipedia.org/wiki/Alexandra_Elbakyan" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T113">Alexandra Elbakyan</text:span></text:a><text:span text:style-name="T140">, une </text:span><text:span text:style-name="T113">étudiante chercheuse</text:span><text:span text:style-name="T83">, ce projet consiste en un logiciel de captation d’articles scientifiques (y compris ceux fermés dans les plateformes de publication</text:span><text:span text:style-name="T140">s</text:span><text:span text:style-name="T83"> propriétaires), qui sont ensuite diffusés sur des portails web décentralisés et autonomes. Sci-Hub témoigne de cette culture de hacktivisme, </text:span><text:span text:style-name="T140">dont les projets sont </text:span><text:soft-page-break/><text:span text:style-name="T83">conçu</text:span><text:span text:style-name="T140">s</text:span><text:span text:style-name="T83"> de manière à être résilient</text:span><text:span text:style-name="T140">s</text:span><text:span text:style-name="T83"> aux pannes, </text:span><text:span text:style-name="T140">aux </text:span><text:span text:style-name="T83">fermetures et interdictions administratives</text:span><text:span text:style-name="T140">,</text:span><text:span text:style-name="T83"> de par </text:span><text:span text:style-name="T140">leur</text:span><text:span text:style-name="T83"> caractère décentralisé : chaque portail d’accès est géré de façon indépendante, mettant en commun les données en mode miroir ; si un portail ferme, d’autres miroirs sont toujours là pour assurer l’accès aux données. Quelques années auparavant, Aaron Swartz</text:span><text:span text:style-name="T140">, un h</text:span><text:span text:style-name="T83">ac</text:span><text:span text:style-name="T140">k</text:span><text:span text:style-name="T83">tiviste </text:span><text:span text:style-name="T154">important</text:span><text:span text:style-name="T83"> de la culture libre</text:span><text:span text:style-name="T140">,</text:span><text:span text:style-name="T83"> jouait</text:span><text:span text:style-name="T140"> </text:span><text:span text:style-name="T83">aussi un rôle déterminant dès 2008 avec ses multiples actions de mise en place d’un portail d’accès aux documents publics administratifs d’abord, puis d’accès aux publications scientifiques. Swartz est également à l’origine de la création des licences libres </text:span><text:span text:style-name="T12">Creative Commons</text:span><text:span text:style-name="T114">, du projet </text:span><text:span text:style-name="T13">Open Library</text:span><text:span text:style-name="T84">, une des nombreuses fonctionnalités de l’</text:span><text:span text:style-name="T13">Internet Archive</text:span><text:span text:style-name="T84">, ce multi-projet d’archivage du web. Tout comme </text:span><text:a xlink:type="simple" xlink:href="https://fr.wikipedia.org/wiki/Alexandra_Elbakyan" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T84">Alexandra Elbakyan</text:span></text:a><text:span text:style-name="T84">, il a fait l’objet de poursuites pénales et de pressions administratives conséquentes. Tous deux ont pourtant joué un rôle déterminant de lanceurs d’alerte dans le domaine de l’ouverture des données publiques et de la science ouverte, terme</text:span><text:span text:style-name="T155">s ces derniers</text:span><text:span text:style-name="T84"> qui ser</text:span><text:span text:style-name="T155">ont</text:span><text:span text:style-name="T84">, quelques années après leur condamnation, tant repris dans les discours et les orientations </text:span><text:span text:style-name="T155">affichées </text:span><text:span text:style-name="T84">des politiques publiques.</text:span></text:p>
   <text:h text:style-name="P43" text:outline-level="2">Vers des codes sources <text:span text:style-name="T86">sous licences </text:span>libres</text:h>
   <text:p text:style-name="P15"><text:span text:style-name="T141">En matière de </text:span>code source, <text:span text:style-name="T85">le combat s’est également déroulé en grande partie dans le milieu de la recherche et </text:span><text:span text:style-name="T141">par </text:span><text:span text:style-name="T85">des hacktivistes d’un internet et d’une informatique libres. La </text:span><text:span text:style-name="T11">Free Software Foundation</text:span><text:span text:style-name="T85"> </text:span><text:span text:style-name="T141">a été</text:span><text:span text:style-name="T85"> créée en 1985 sous l’impulsion du chercheur Richard Stallman, pour tenter de donner un cadre légal de protection et de promotion des logiciels libres. C’est ainsi que la plus emblématique des licences libres dites </text:span><text:span text:style-name="T5">copyleft</text:span><text:span text:style-name="T86"> </text:span><text:span text:style-name="T141">a vu</text:span><text:span text:style-name="T86"> le jour : la GNU </text:span><text:span text:style-name="T5">General Public Licence</text:span><text:span text:style-name="T86"> (GPL). Cette licence va non seulement introduire les quatre libertés fondamentales qui caractérisent le logiciel libre</text:span><text:note text:id="ftn9" text:note-class="footnote"><text:note-citation>9</text:note-citation><text:note-body>
      <text:p text:style-name="Footnote"><text:a xlink:type="simple" xlink:href="https://www.gnu.org/philosophy/free-sw.html#four-freedoms" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T141">https://www.gnu.org/philosophy/</text:span></text:a></text:p></text:note-body></text:note><text:span text:style-name="T86">, mais elle va également s’assurer de la pérennité de cette liberté à travers la notion de </text:span><text:span text:style-name="T5">copyleft</text:span><text:span text:style-name="T86">, également appelé</text:span><text:span text:style-name="T141">e</text:span><text:span text:style-name="T86"> </text:span><text:span text:style-name="T5">share-alik</text:span><text:span text:style-name="T86">e (le « SA » des licences </text:span><text:span text:style-name="T5">Creative Commons</text:span><text:span text:style-name="T86">). Le </text:span><text:span text:style-name="T14">copyleft</text:span><text:span text:style-name="T86"> va permettre à un code libre de ne pas se retrouver enfermé dans un code propriétaire non libre au cours de son existence et va ainsi assurer la persistance du caractère libre du code à travers les modifications et les transformations de celui-ci. </text:span><text:span text:style-name="T141">C’est</text:span><text:span text:style-name="T86"> là un principe protecteur très fort, qui revendique la centralité de la notion éthique de liberté dans l’idéologie et la culture du Libre. </text:span><text:span text:style-name="T141">Ainsi, l</text:span><text:span text:style-name="T86">e principe de </text:span><text:span text:style-name="T5">copyleft</text:span><text:span text:style-name="T86"> </text:span><text:span text:style-name="T141">est-il fondamental pour éviter que du code ouvert ne soit </text:span><text:span text:style-name="T86">enferm</text:span><text:span text:style-name="T141">é</text:span><text:span text:style-name="T86"> dans du code source propriétaire, </text:span><text:span text:style-name="T141">comme il advient </text:span><text:span text:style-name="T86">de plus en plus </text:span><text:span text:style-name="T141">dans </text:span><text:span text:style-name="T86">les grandes sociétés privées monopolistiques et privatrices telles que les GAFAM (Google, Amazon, Facebook, Apple et Microsoft).</text:span></text:p>
   <text:p text:style-name="P29"><text:span text:style-name="T87">En 1995</text:span>, l’<text:span text:style-name="T3">Open Source Initiative</text:span> <text:span text:style-name="T87">présente la définition de logiciel </text:span><text:span text:style-name="T15">Open Source</text:span><text:span text:style-name="T87">. Cette définition peu connue en détails, et employée à tort pour désigner tout code ouvert dans </text:span><text:span text:style-name="T142">l&apos;acception de </text:span>« <text:span text:style-name="T87">accessible</text:span> »<text:span text:style-name="T87">, </text:span><text:span text:style-name="T142">r</text:span><text:span text:style-name="T87">enferme en réalité dix conditions</text:span><text:note text:id="ftn10" text:note-class="footnote"><text:note-citation>10</text:note-citation><text:note-body>
      <text:p text:style-name="Footnote"><text:a xlink:type="simple" xlink:href="https://opensource.org/osd" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T142">https://opensource.org</text:span></text:a></text:p></text:note-body></text:note><text:span text:style-name="T87"> qui assurent entre autres les quatre libertés fondamentales des logiciels libres. Les deux types de licences, libres et open source vont coïncider la plupart du temps, mais le terme de logiciel libre </text:span><text:span text:style-name="T143">est</text:span><text:span text:style-name="T87"> préféré par ceux qui souhaitent mettre l’accent sur la </text:span><text:span text:style-name="T143">notion de </text:span><text:span text:style-name="T87">liberté</text:span><text:span text:style-name="T143"> ainsi que sur</text:span><text:span text:style-name="T87"> le caractère idéologique et politique qu’elle revêt.</text:span></text:p>
   <text:p text:style-name="P16"><text:span text:style-name="T88">En France, l’April est la plus grande association de défense et de promotion les logiciels libres, qui était nommée ainsi au départ en tant qu’acronyme d’Association </text:span><text:span text:style-name="T155">P</text:span><text:span text:style-name="T88">our la </text:span><text:span text:style-name="T155">R</text:span><text:span text:style-name="T88">echerche en </text:span><text:span text:style-name="T155">I</text:span><text:span text:style-name="T88">nformatique </text:span><text:span text:style-name="T155">L</text:span><text:span text:style-name="T88">ibre. Notons également deux autres grandes associations dans le domaine : Framasoft d’une part, qui met l’accent sur l’éducation populaire via la culture libre au sens général et d’autre part</text:span><text:span text:style-name="T144">,</text:span><text:span text:style-name="T88"> La Quadrature du Net, qui focalise ses actions sur les libertés numériques. Ces associations jouent un rôle important dans le plaidoyer, l’activisme, et la défense de la culture libre.</text:span></text:p>
   <text:p text:style-name="P16"><text:span text:style-name="T115">Notons également une ressource européenne importante que l’on doit à l</text:span>a campagne « <text:change-start text:change-id="ct94327731267776"/><text:span text:style-name="T3">Public Money, Public Code</text:span><text:change-end text:change-id="ct94327731267776"/> » <text:span text:style-name="T104">portée par la </text:span><text:span text:style-name="T3">Free Software Foundation</text:span> Europe, <text:span text:style-name="T124">qui </text:span>résume <text:span text:style-name="T117">dans sa brochure <text:s/></text:span><text:soft-page-break/>l<text:span text:style-name="T116">es bénéfices et apports multiples </text:span>d<text:span text:style-name="T144">e l’</text:span>ouverture d<text:span text:style-name="T144">u</text:span> code source produit <text:span text:style-name="T116">et utilisé </text:span>dans <text:span text:style-name="T144">le</text:span> cadre de<text:span text:style-name="T144"> la </text:span><text:s/>recherche <text:span text:style-name="T89">publique </text:span><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__709949_151231740">[12]</text:bookmark-ref><text:span text:style-name="T105">.</text:span></text:p>
   <text:h text:style-name="Heading_20_2" text:outline-level="2"><text:span text:style-name="T106">Vers des obligations légales, </text:span><text:span text:style-name="T107">mais</text:span><text:span text:style-name="T106"> des pratiques en demi-teinte</text:span></text:h>
   <text:p text:style-name="P18"><text:span text:style-name="T90">En termes de politiques publiques, les expressions science ouverte et données ouvertes sont progressivement entrées dans le vocabulaire et </text:span><text:span text:style-name="T145">dans </text:span><text:span text:style-name="T90">les plans des gouvernements et tutelles de la recherche. En France</text:span><text:span text:style-name="T145">,</text:span><text:span text:style-name="T90"> l’obligation légale s’instaure enfin en 2016 à l’occasion du </text:span><text:span text:style-name="T145">P</text:span><text:span text:style-name="T90">lan pour une République numérique</text:span><text:note text:id="ftn11" text:note-class="footnote"><text:note-citation>11</text:note-citation><text:note-body>
      <text:p text:style-name="Footnote"><text:a xlink:type="simple" xlink:href="https://www.economie.gouv.fr/republique-numerique" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T145">Loi pour une République numérique</text:span></text:a><text:span text:style-name="T145">.</text:span></text:p></text:note-body></text:note><text:span text:style-name="T104">. Depuis cette date, les données de la recherche, y compris le code source </text:span><text:span text:style-name="T146">des logiciels </text:span><text:span text:style-name="T104">produits, sont considérées comme des données administratives publiques et sont soumises à ce titre à la même obligation de publication que ces dernières, au titre du Code des Relations entre le Public et l’Administration. Ce plan sera renommé en 2018 </text:span>Plan national pour la science ouverte <text:span text:style-name="T90">et porte désormais comme sous-inscription </text:span>: <text:span text:style-name="T90">« </text:span>les résultats de la recherche scientifique ouvert<text:span text:style-name="T146">s</text:span> à tous, sans<office:annotation>
     <dc:creator>Filippo Matteo Rusconi</dc:creator>
     <dc:date>2022-01-12T09:34:34.740752134</dc:date>
     <meta:creator-initials>FMR</meta:creator-initials>
     <text:p text:style-name="P88"><text:span text:style-name="T161">On ne comprend pas si ce sont les résultats qui sont ouverts à tous ou la recherche scientifique qui est ouverte à tous. Je ne crois pas que la deuxième proposition soit la bonne :-)</text:span></text:p>
    </office:annotation><office:annotation>
     <dc:creator>David Verdin</dc:creator>
     <dc:date>2022-01-13T18:21:02.981498651</dc:date>
     <meta:creator-initials>DV</meta:creator-initials>
     <text:p text:style-name="P88"><text:span text:style-name="T162">Reply to Filippo Matteo Rusconi (12/01/2022, 09:34): &quot;...&quot;</text:span></text:p>
     <text:p><text:span text:style-name="T160">Pourtant on dirait bien que c’est la deuxième : « ouverte » fait référence à « recherche », pas à « résultats ».</text:span></text:p>
    </office:annotation><office:annotation>
     <dc:creator>Filippo Matteo Rusconi</dc:creator>
     <dc:date>2022-01-19T13:25:22.064634883</dc:date>
     <meta:creator-initials>FMR</meta:creator-initials>
     <text:p text:style-name="P87"><text:span text:style-name="T162">Reply to David Verdin (01/13/2022, 18:21): &quot;...&quot;</text:span></text:p>
     <text:p><text:span text:style-name="T160">Non, c’est bien ce que je pensais : les résultats sont ouverts. Vérification : https://www.enseignementsup-recherche.gouv.fr/fr/le-plan-national-pour-la-science-ouverte-les-resultats-de-la-recherche-scientifique-ouverts-tous-49241</text:span></text:p>
    </office:annotation> entrave, sans délai, sans paiement <text:span text:style-name="T104">».</text:span></text:p>
   <text:p text:style-name="P17"><text:span text:style-name="T88">Les logiciels libres et </text:span><text:span text:style-name="T16">open source</text:span><text:span text:style-name="T88"> se retrouvent aujourd’hui partout autour de nous, et cela bien souvent de manière non visible : les serveurs, les sites web, les objets intelligents, les services dans le </text:span><text:span text:style-name="T17">cloud</text:span><text:span text:style-name="T125">, reposent en grande majorité sur des logiciels et </text:span><text:span text:style-name="T147">des </text:span><text:span text:style-name="T125">systèmes d’exploitation libres. Ce n’est pas le cas des environnements personnels de travail, ni des services utilisés au quotidien sur ces environnements, dominés et monopolisés par les GAFAM qui proposent des outils la plupart du temps non libres et soumis à des restrictions d’usage diverses et variées (coût élevé, code source fermé, usage unique, DRM</text:span><text:note text:id="ftn12" text:note-class="footnote"><text:note-citation>12</text:note-citation><text:note-body>
      <text:p text:style-name="Footnote">« Digital Rights Management »<text:span text:style-name="T147"> (gestion [restrictive] des droits numériques, principalement des droits d&apos;auteur</text:span><text:span text:style-name="T148">, contre laquelle lu</text:span><text:span text:style-name="T150">tte la campagne </text:span><text:span text:style-name="T149"><text:s/></text:span><text:a xlink:type="simple" xlink:href="https://www.defectivebydesign.org/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T150">« Defective by design »</text:span></text:a><text:span text:style-name="T149">).</text:span></text:p>
      <text:p text:style-name="P59"/></text:note-body></text:note><text:span text:style-name="T88"> intégrés, captation de données personnelles en échange de service, obsolescence, etc.). </text:span><office:annotation office:name="__Annotation__3625_4175847089" loext:resolved="false">
     <dc:creator>Auteur inconnu</dc:creator>
     <dc:date>2022-01-12T20:19:21.755000000</dc:date>
     <text:p text:style-name="P88"><text:span text:style-name="T161">Tous sauf un petit ENT breton qui s’appelle Toutatice pour les 1</text:span><text:span text:style-name="T163">er</text:span><text:span text:style-name="T161"> et 2</text:span><text:span text:style-name="T163">e</text:span><text:span text:style-name="T161"> cycles et ESUP-Portal pour le supérieur. C’est un breton ex ESUP qui parle… :-).</text:span></text:p>
    </office:annotation><text:span text:style-name="T88">Ce n’est pas non plus le ca</text:span><text:span text:style-name="T156">s </text:span><text:span text:style-name="T88">des environnements de travail de l’administration publique, ni de celui des millions d’élèves et </text:span><text:span text:style-name="T156">d’</text:span><text:span text:style-name="T88">étudiants qui sont confrontés de plus en plus tôt à un environnement et des services informatiques dominés par les contrats publics passés avec les GAFAM et autres sociétés aux pratiques privatrices et liberticides</text:span><office:annotation-end office:name="__Annotation__3625_4175847089"/><text:change-start text:change-id="ct94327733081984"/><office:annotation>
     <dc:creator>eda</dc:creator>
     <dc:date>2022-02-23T14:02:48.572830909</dc:date>
     <meta:creator-initials>e</meta:creator-initials>
     <text:p text:style-name="P87"><text:span text:style-name="T162">Reply to Auteur inconnu (12/01/2022, 20:19): &quot;...&quot;</text:span></text:p>
     <text:p><text:span text:style-name="T160">Et oui heureusement il y a des belles initiatives qui ne vont pas que dans ce sens &lt;3 Mais là je parle des gros contrats surtout.</text:span></text:p>
    </office:annotation><text:change-end text:change-id="ct94327733081984"/><office:annotation>
     <dc:creator>David Verdin</dc:creator>
     <dc:date>2022-01-13T18:23:05.371083161</dc:date>
     <meta:creator-initials>DV</meta:creator-initials>
     <text:p text:style-name="P88"><text:span text:style-name="T162">Reply to Auteur inconnu (12/01/2022, 20:19): &quot;...&quot;</text:span></text:p>
     <text:p><text:span text:style-name="T160">💘</text:span></text:p>
    </office:annotation><office:annotation>
     <dc:creator>Filippo Matteo Rusconi</dc:creator>
     <dc:date>2022-01-19T13:32:50.121086221</dc:date>
     <meta:creator-initials>FMR</meta:creator-initials>
     <text:p text:style-name="P87"><text:span text:style-name="T162">Reply to David Verdin (01/13/2022, 18:23): &quot;...&quot;</text:span></text:p>
     <text:p><text:span text:style-name="T160">+1 :-)</text:span></text:p>
    </office:annotation> <text:span text:style-name="T156">(citons par exemple le partenariat en 2015 entre Microsoft et l’Éducation Nationale</text:span><text:span text:style-name="T156"><text:note text:id="ftn13" text:note-class="footnote"><text:note-citation>13</text:note-citation><text:note-body>
       <text:p text:style-name="Footnote">https://www.april.org/microsoft-educ-nat-partenariat-indigne<text:change-start text:change-id="ct94327733147968"/>/<text:change-end text:change-id="ct94327733147968"/></text:p></text:note-body></text:note></text:span><text:span text:style-name="T156">, ou encore les tablettes numériques pour tous au collège sous système Windows de Microsoft</text:span><text:span text:style-name="T155">).</text:span></text:p>
   <text:h text:style-name="P40" text:outline-level="2">Apports du libre</text:h>
   <text:p text:style-name="P71">L’exemple de la plateforme PAPPSO ci-dessus nous démontre l’intérêt scientifique à libérer ses codes sources et son infrastructure de travail. Le logiciel libre et les infrastructures libres en milieu de recherche permettent et facilitent :</text:p>
   <text:list xml:id="list1325409576" text:style-name="L1">
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     <text:p text:style-name="P83"><office:annotation>
       <dc:creator>Pascal AUBRY</dc:creator>
       <dc:date>2022-02-03T05:57:15.409000000</dc:date>
       <meta:creator-initials>PA</meta:creator-initials>
       <text:p text:style-name="P87"><text:span text:style-name="T161">Style Liste 1</text:span></text:p>
      </office:annotation>un niveau de technicité et d’autonomie incomparable avec celui des logiciels propriétaires : <text:span text:style-name="T91">le </text:span>paramétrage fin des logiciels <text:span text:style-name="T91">libres</text:span>, leur adapta<text:span text:style-name="T91">bilité et l’autonomie dans la réalisation de ces adaptations</text:span><text:span text:style-name="T151">, l&apos;émulation positive entre développeurs ainsi que l&apos;auto-apprentissage (le code source ouvert et libre est un outil didactique en soi)</text:span><text:span text:style-name="T91"> </text:span>;<text:change-start text:change-id="ct94327635645184"/></text:p>
    </text:list-item>
    <text:list-item>
     <text:p text:style-name="P85"><text:change-end text:change-id="ct94327635645184"/>une meilleure productivité / efficacité : le mode de développement et de production scientifique libre est agile <text:span text:style-name="T92">par construction </text:span>: les besoins de la recherche peuvent être rapidement assouvis par <text:span text:style-name="T93">l</text:span>e paramétrage et <text:span text:style-name="T93">l’</text:span>adaptation du code source, <text:span text:style-name="T93">ou par la </text:span>réutilisation de code source <text:span text:style-name="T93">libre</text:span> tier<text:span text:style-name="T151">s</text:span>. <text:span text:style-name="T93">Ce code source </text:span>bénéficie <text:span text:style-name="T93">à </text:span><text:span text:style-name="T151">son </text:span><text:span text:style-name="T93">tour de la recherche s</text:span>cientifique pour s’enrichir de nouvelles fonctionnalité<text:span text:style-name="T119">s</text:span> <text:span text:style-name="T91">lors</text:span> <text:span text:style-name="T91">de</text:span> cycle<text:span text:style-name="T91">s</text:span> <text:span text:style-name="T92">développement</text:span><text:span text:style-name="T151">, test et</text:span><text:span text:style-name="T92"> mise en production</text:span> court<text:span text:style-name="T91">s</text:span> et <text:span text:style-name="T91">nombreux </text:span>;</text:p>
    </text:list-item>
    <text:list-item>
     <text:p text:style-name="P83"><text:soft-page-break/><text:span text:style-name="T118">une meilleure</text:span> collaboration <text:span text:style-name="T151">grâce au</text:span><text:span text:style-name="T118"> caractère ouvert d</text:span><text:span text:style-name="T151">u</text:span><text:span text:style-name="T118"> code source et </text:span><text:span text:style-name="T151">aux libertés conférées par l</text:span><text:span text:style-name="T118">es licences d’utilisation ;</text:span><text:change-start text:change-id="ct94327731225504"/></text:p>
    </text:list-item>
    <text:list-item>
     <text:p text:style-name="P83"><text:change-end text:change-id="ct94327731225504"/><text:span text:style-name="T118">un premier pas indispensable vers </text:span>la sécurité logiciell<text:span text:style-name="T92">e </text:span>: l’accès au code source permet un audit <text:span text:style-name="T127">de sécurité par la communauté</text:span> et ne nécessite pas de croire sur parole des fabricants aux conflit<text:span text:style-name="T118">s</text:span> d’intérêts évidents ;<text:change-start text:change-id="ct94327731246400"/></text:p>
    </text:list-item>
    <text:list-item>
     <text:p text:style-name="P83"><text:change-end text:change-id="ct94327731246400"/>une meilleure reproductibilité des résultats scientifiques : nul besoin de devoir ac<text:span text:style-name="T118">quérir</text:span> <text:span text:style-name="T118">les droits d’utilisation</text:span> pour pouvoir reproduire <text:span text:style-name="T93">des résultats obtenus </text:span><text:span text:style-name="T151">avec des</text:span><text:span text:style-name="T93"> logiciels libres ;</text:span></text:p>
    </text:list-item>
    <text:list-item>
     <text:p text:style-name="P82">une meilleure interopérabilité : les formats de données des logiciels libres sont ouverts et souvent standardisés. Les logiciels propriétaires reposent souvent sur des formats de données fermés et propres à chaque <text:span text:style-name="T151">éditeur</text:span>, rendant l’interopérabilité impossible ou difficile. Cela provoque des achats forcés et une obsolescence matérielle et logicielle qui a un coût économique et écologique non négligeable.</text:p>
    </text:list-item>
   </text:list>
   <text:h text:style-name="P41" text:outline-level="2">Le libre en pratique</text:h>
   <text:p text:style-name="P31"><text:span text:style-name="T120">Etalab est le département de la direction interministérielle du numérique (DINUM) qui </text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">coordonne </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T121">la politique d’ouverture et de partage des données publiques </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">des administrations de l’</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T61">É</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">tat</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">. Ce département </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T76">a</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">pporte son appui </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">aux administrations </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">pour </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T70">leur permettre de répondre </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">aux</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T70"> obligations légales d’ouverture</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">. </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T62">Il propose et maintien</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T61">t</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T62"> n</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T65">otamment :</text:span></text:span></text:p>
   <text:list xml:id="list2403781355" text:style-name="L2">
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     <text:p text:style-name="P84"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T65">la plateforme </text:span></text:span><text:a xlink:type="simple" xlink:href="https://code.gouv.fr/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T65">https://code.gouv.fr/</text:span></text:span></text:a><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T65"> qui recense aujourd’hui les dépôts et </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">le </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T65">code source d</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T80">es logiciels du</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T65"> secteur public </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T62">et qui invite ceux qui n’y sont pas répertoriés à s’y ajouter ;</text:span></text:span></text:p>
    </text:list-item>
    <text:list-item>
     <text:p text:style-name="P84"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">la plateforme </text:span></text:span><text:a xlink:type="simple" xlink:href="https://data.gouv.fr/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">https://data.gouv.fr</text:span></text:span></text:a><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59"> de diffusion de données publiques ;</text:span></text:span></text:p>
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     <text:p text:style-name="P84"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63">le SILL : Socle Interministériel de Logiciels Libres (</text:span></text:span><text:a xlink:type="simple" xlink:href="https://sill.etalab.gouv.fr/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63">https://sill.etalab.gouv.fr</text:span></text:span></text:a><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63">)</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">,</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63"> un catalogue qui référence les logiciels libres recommandés pour les administrations ;</text:span></text:span></text:p>
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     <text:p text:style-name="P84"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63">un guide légal des obligations de</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">s</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63"> publications administratives : <text:s/></text:span></text:span><text:a xlink:type="simple" xlink:href="https://guides.etalab.gouv.fr/algorithmes/guide/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63">https://guides.etalab.gouv.fr/algorithmes/guide/</text:span></text:span></text:a><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T63">;</text:span></text:span></text:p>
    </text:list-item>
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     <text:p text:style-name="P84"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66">un accompagnement sur mesure </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T62">pour assurer les obligations d’ouverture des données ; </text:span></text:span></text:p>
    </text:list-item>
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     <text:p text:style-name="P84"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66">un groupe de travail logiciels libres </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T69">sur la plateforme </text:span></text:span><text:a xlink:type="simple" xlink:href="https://communs.numerique.gouv.fr/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T68">https://communs.numerique.gouv.fr/</text:span></text:span></text:a><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T68"> du Plan d’action logiciels libres et communs numériques. Notons en particulier la gazette et les ateliers vidéo BlueHats</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T68"><text:note text:id="ftn14" text:note-class="footnote"><text:note-citation>14</text:note-citation><text:note-body>
          <text:p text:style-name="Footnote">https://communs.numerique.gouv.fr/bluehats/</text:p></text:note-body></text:note></text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T68">.</text:span></text:span></text:p>
    </text:list-item>
   </text:list>
   <text:p text:style-name="P27"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T68">L</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66">e portail </text:span></text:span><text:a xlink:type="simple" xlink:href="https://www.ouvrirlascience.fr/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66">https://www.ouvrirlascience.fr/</text:span></text:span></text:a><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66"> mis en place par le Comité pour la science ouverte du MESRI, propose lui aussi différents guides et recommandations.</text:span></text:span></text:p>
   <text:p text:style-name="P28"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T70">Le portail du CNRS pour la science ouverte (</text:span></text:span><text:a xlink:type="simple" xlink:href="https://www.science-ouverte.cnrs.fr/" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T70">https://www.science-ouverte.cnrs.fr/</text:span></text:span></text:a><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T70">) référence également des dépôts publics de code source, de publications scientifiques et de données de la recherche.</text:span></text:span></text:p>
   <text:p text:style-name="P27"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66">Notons également l’initiative publique </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T21">Software Heritage</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66"><text:note text:id="ftn15" text:note-class="footnote"><text:note-citation>15</text:note-citation><text:note-body>
        <text:p text:style-name="Footnote">https://www.softwareheritage.org</text:p></text:note-body></text:note></text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66">, qui vise à créer une archive universelle des logiciels à laquelle vous pouvez vous-même contribuer en y inscrivant vo</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">tre</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66"> code source.</text:span></text:span></text:p>
   <text:p text:style-name="P27"><text:soft-page-break/><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66">Enfin, l’initiative REUSE</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66"><text:note text:id="ftn16" text:note-class="footnote"><text:note-citation>16</text:note-citation><text:note-body>
        <text:p text:style-name="Footnote">https://reuse.software/</text:p></text:note-body></text:note></text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T66"> de la </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T22">Free Software Foundation</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T67"> Europe vise à faciliter, voir</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T79">e</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T67"> à automatiser la mise sous licence libre de logiciels qui comportent différentes briques de code source, </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T74">chacun</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T77">e</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T74"> portant potentiellement une</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T67"> licence libre différente. REUSE calcule </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T70">l’inter</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T77">compatibilité</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T70"> </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T67">de ces licences et </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T77">permet ainsi </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T67">de les combiner </text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T77">pour une</text:span></text:span><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T67"> mise sous licence du logiciel complet.</text:span></text:span></text:p>
   <text:h text:style-name="P50" text:outline-level="1"><text:span text:style-name="T26">Bilan</text:span></text:h>
   <text:p text:style-name="Standard"><text:span text:style-name="T94">Le passage au logiciel libre pour tous les besoins informatiques de la plateforme PAPPSO a permis une maîtrise totale de ses outils, depuis la production des données brutes jusqu’à l’interprétation biologique. Les sommes importantes économisées en licences de logiciels propriétaires (20 k€ par an) ont été investies dans la maintenance des ressources de calcul et de stockage. Toutes les analyses sont complètement vérifiables et reproductibles, les logiciels étant tous librement téléchargeables, sous licence GPLv3+, sans demande préalable. Le savoir-faire développé par PAPPSO dans l’analyse protéomique à haut débit est reconnu au niveau international (129 articles citant MassChroQ depuis 2011, publication d’un article de référence en métaprotéomique </text:span><text:span text:style-name="T94"><text:bookmark-ref text:reference-format="number" text:ref-name="__RefNumPara__4411_4199412181">[11]</text:bookmark-ref></text:span><text:span text:style-name="T94">). </text:span></text:p>
   <text:p text:style-name="P86"><text:span text:style-name="T33">L’exemple de la plateforme PAPPSO n’est pas unique, d</text:span><text:span text:style-name="T48">e multiples autres initiatives locales </text:span><text:span text:style-name="T49">similaires ont lieu constamment.</text:span><text:span text:style-name="T48"> </text:span><text:span text:style-name="T49">L’initiative </text:span><text:span text:style-name="T50">apps.education.fr</text:span><text:span text:style-name="T49"><text:note text:id="ftn17" text:note-class="footnote"><text:note-citation>17</text:note-citation><text:note-body>
       <text:p text:style-name="Footnote">https://apps.education.fr/</text:p></text:note-body></text:note></text:span><text:span text:style-name="T49">, cette plateforme de services libres et éthiques pour travailler à distance née à l’occasion de la crise pandémique que l’Education Nationale est en train de pérenniser et d’étendre, en est un superbe exemple. </text:span><text:span text:style-name="T48">L</text:span><text:span text:style-name="T33">e monde de la recherche a </text:span><text:span text:style-name="T44">toujours </text:span><text:span text:style-name="T33">joué un rôle de précurseur, se positionnant comme un acteur </text:span><text:span text:style-name="T44">primordial</text:span><text:span text:style-name="T33"> dans le long processus d’ouverture de la science, </text:span><text:span text:style-name="T46">des formats de données, </text:span><text:span text:style-name="T33">des données publiques et de la préservation des savoirs communs. </text:span><text:span text:style-name="T44">Aidé</text:span><text:span text:style-name="T41"> </text:span><text:span text:style-name="T33">par les mouvements militants et activistes, le </text:span><text:span text:style-name="T42">chemin parcouru est</text:span><text:span text:style-name="T33"> considérable. </text:span><text:span text:style-name="T43">M</text:span><text:span text:style-name="T33">ais </text:span><text:span text:style-name="T44">le</text:span><text:span text:style-name="T41">s politiques publiques de financement et d’orientation de la recherche semblent </text:span><text:span text:style-name="T44">contradictoires et insuffisantes.</text:span><text:span text:style-name="T33"> </text:span><text:span text:style-name="T41">Les récentes avancées comme la remise « prix science ouverte des données de recherche et du logiciel libre de la recherche » seront peut-être l’occasion de prendre conscience de la richesse de nos productions et de favoriser la cohérence entre les discours et les actes.</text:span><text:change-start text:change-id="ct94327733295008"/><text:span text:style-name="T41"><office:annotation>
      <dc:creator>eda</dc:creator>
      <dc:date>2022-02-23T14:30:15.900769570</dc:date>
      <meta:creator-initials>e</meta:creator-initials>
      <text:p text:style-name="P87"><text:span text:style-name="T162">Reply to Auteur inconnu (12/01/2022, 20:28): &quot;...&quot;</text:span></text:p>
      <text:p><text:span text:style-name="T160">Merci pour vos commentaires. J’ai un peu changé la conclusion, j’ai ajouté un exemple et je laisse la question ouverte.</text:span></text:p>
     </office:annotation></text:span><text:change-end text:change-id="ct94327733295008"/><text:span text:style-name="T41"><office:annotation>
      <dc:creator>David Verdin</dc:creator>
      <dc:date>2022-01-13T18:28:42.810427314</dc:date>
      <meta:creator-initials>DV</meta:creator-initials>
      <text:p text:style-name="P88"><text:span text:style-name="T162">Reply to Auteur inconnu (12/01/2022, 20:28): &quot;...&quot;</text:span></text:p>
      <text:p><text:span text:style-name="T160">Assez d’accord. Pourquoi pas un hypothèse de collaboration entre structures de recherche publique dans un contexte de soudaine pandémie ? Aurions-nous vécu la même gabegie ?</text:span></text:p>
     </office:annotation></text:span></text:p>
   <text:p text:style-name="Titre_20_Bibliographie">Bibliographie<text:change-start text:change-id="ct94327733289808"/><office:annotation>
     <dc:creator>Auteur inconnu</dc:creator>
     <dc:date>2022-01-24T16:22:22.397000000</dc:date>
     <text:p text:style-name="P87"><text:span text:style-name="T161">Remise en forme des références biblio pour une meilleure présentation des items &gt; 10.</text:span></text:p>
    </office:annotation><text:change-end text:change-id="ct94327733289808"/></text:p>
   <text:list xml:id="list852081016" text:style-name="Numbering_20_4">
    <text:list-item>
     <text:p text:style-name="P74"><text:bookmark-start text:name="__RefNumPara__4219_4199412181"/><text:span text:style-name="T33">Rusconi</text:span> F. Free Open Source Software for Protein and Peptide Mass Spectrometry- based Science. Curr Protein Pept Sci, 2 (22) 134-147, 2021 ; https://doi.org/10.2174/1389203722666210118160946<text:bookmark-end text:name="__RefNumPara__4219_4199412181"/></text:p>
    </text:list-item>
    <text:list-item>
     <text:p text:style-name="P75"><text:bookmark-start text:name="__RefNumPara__4321_4199412181"/>Langella O. , Valot B., Jacob D., Balliau T., Flores R., Hoogland C., Joets J., Zivy M.. (2013) Management and dissemination of MS proteomic data with PROTICdb: Example of a quantitative comparison between methods of protein extraction. Proteomics, 9 (13) 1457-66<text:bookmark-end text:name="__RefNumPara__4321_4199412181"/></text:p>
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     <text:p text:style-name="P76"><text:bookmark-start text:name="__RefNumPara__4323_4199412181"/>Langella O, Rusconi F. mineXpert2: Full-Depth Visualization and Exploration of MSn Mass Spectrometry Data. J. Am. Soc. Mass Spectrom., 4 (32) 1138-114, mars 2021 ; https://doi.org/10.1021/jasms.0c00402<text:bookmark-end text:name="__RefNumPara__4323_4199412181"/></text:p>
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     <text:p text:style-name="P76"><text:bookmark-start text:name="__RefNumPara__4176_4199412181"/>Langella O, Valot B, Balliau T, Blein-Nicolas M, Bonhomme L, Zivy M. X!TandemPipeline: A Tool to Manage Sequence Redundancy for Protein Inference and Phosphosite Identification. J. Proteome Res., 2 (16) 494-503, décembre 2016 ; <text:a xlink:type="simple" xlink:href="https://doi.org/10.1021/acs.jproteome.6b00632" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://doi.org/10.1021/acs.jproteome.6b00632</text:a><text:bookmark-end text:name="__RefNumPara__4176_4199412181"/></text:p>
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     <text:p text:style-name="P77"><text:bookmark-start text:name="__RefNumPara__2718_4175847089"/>Valot B, Langella O, Nano E, Zivy M. MassChroQ: a versatile tool for mass spectrometry quantification. Proteomics, 17 (11) 3572-3577, juin 2011 ; <text:a xlink:type="simple" xlink:href="https://doi.org/10.1002/pmic.201100120" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://doi.org/10.1002/pmic.201100120</text:a><text:bookmark-end text:name="__RefNumPara__2718_4175847089"/></text:p>
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     <text:p text:style-name="P78"><text:bookmark-start text:name="__RefNumPara__1061291_151231740"/><text:soft-page-break/>El<text:span text:style-name="T116">i</text:span>nor Ostirom. Governing the Commons : the evolution of institutions for collective actions, 1990, Cambridge University Press ; <text:a xlink:type="simple" xlink:href="https://archive.org/details/ElinorOstromGoverningTheCommons" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://archive.org/details/ElinorOstromGoverningTheCommons</text:a><text:bookmark-end text:name="__RefNumPara__1061291_151231740"/></text:p>
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     <text:p text:style-name="P78"><text:bookmark-start text:name="__RefNumPara__126661_151231740"/><text:span text:style-name="T110">Maurel Lionel. </text:span>L’ouverture des données de recherche : un retour aux sources de l’Ethos de la Science ? <text:span text:style-name="T110">Colloque Intégrité Scientifique et Science Ouverte, avril 2019 ; </text:span><text:a xlink:type="simple" xlink:href="https://scinfolex.com/2019/06/05/louverture-des-donnees-de-recherche-un-retour-aux-sources-de-lethos-de-la-science" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T110">https://scinfolex.com/2019/06/05/louverture-des-donnees-de-recherche-un-retour-aux-sources-de-lethos-de-la-science</text:span></text:a><text:bookmark-end text:name="__RefNumPara__126661_151231740"/></text:p>
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     <text:p text:style-name="P79"><text:bookmark-start text:name="__RefNumPara__2284_944871799"/><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T59">MESRI, L’état de l&apos;Enseignement supérieur, de la Recherche et de l&apos;Innovation en France n°14, 2021 ; </text:span></text:span><text:a xlink:type="simple" xlink:href="https://publication.enseignementsup-recherche.gouv.fr/eesr/FR/T622/le_financement_des_activites_de_recherche_et_developpement_de_la_recherche_publique" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="Strong_20_Emphasis"><text:span text:style-name="T64">https://publication.enseignementsup-recherche.gouv.fr/eesr</text:span></text:span></text:a><text:bookmark-end text:name="__RefNumPara__2284_944871799"/></text:p>
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     <text:p text:style-name="P80"><text:bookmark-start text:name="__RefNumPara__1183515_151231740"/><text:span text:style-name="T58">CNRS. La recherche publique en France en 2019 : diagnostic et propositions du Comité national, 2019; <text:s/></text:span><text:a xlink:type="simple" xlink:href="https://www.cnrs.fr/comitenational/Actualites/Propositions_Comite-national_Juillet-2019.pdf" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://www.cnrs.fr/comitenational/Actualites/Propositions_Comite-national_Juillet-2019.pdf</text:a><text:bookmark-end text:name="__RefNumPara__1183515_151231740"/></text:p>
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     <text:p text:style-name="P77"><text:bookmark-start text:name="__RefNumPara__313535_151231740"/><text:span text:style-name="T112">Bosc H, Poynder R. The Open Access Interviews, 2009 ; </text:span><text:a xlink:type="simple" xlink:href="../../../../../eda/Conf-JRES-April-Pappso/MESRI,%20L’état%20de%20l&apos;Enseignement%20supérieur,%20de%20la%20Recherche%20et%20de%20l&apos;Innovation%20en%20France%20n°14,%202021%20%3B%20https://publication.enseignementsup-recherche.gouv.fr/eesr/FR/T622/le_financement_des_activites_de_recherche_et_developpement_de_la_recherche_publique" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://www.richardpoynder.co.uk/Helene_Bosc_Interview.pdf</text:a><text:bookmark-end text:name="__RefNumPara__313535_151231740"/></text:p>
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     <text:p text:style-name="P76"><text:bookmark-start text:name="__RefNumPara__4411_4199412181"/>Van Den Bossche T, Kunath BJ, Schallert K, Schäpe SS, Abraham PE, Armengaud J, Arntzen M, Bassignani A, Benndorf D, Fuchs S, Giannone RJ, Griffin TJ, Hagen LH, Halder R, Henry C, Hettich RL, Heyer R, Jagtap P, Jehmlich N, Jensen M, Juste C, Kleiner M, Langella O, Lehmann T, Leith E, May P, Mesuere B, Miotello G, Peters SL, Pible O, Queiros PT, Reichl U, Renard BY, Schiebenhoefer H, Sczyrba A, Tanca A, Trappe K, Trezzi JP, Uzzau S, Verschaffelt P, von Bergen M, Wilmes P, Wolf M, Martens L, Muth T. Critical Assessment of MetaProteome Investigation (CAMPI): a multi-laboratory comparison of established workflows. Nature Communiations, 1 (12) 7305, décembre 2021 ; <text:a xlink:type="simple" xlink:href="https://doi.org/10.1038/s41467-021-27542-8" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link">https://doi.org/10.1038/s41467-021-27542-8</text:a><text:bookmark-end text:name="__RefNumPara__4411_4199412181"/></text:p>
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     <text:p text:style-name="P81"><text:bookmark-start text:name="__RefNumPara__709949_151231740"/><text:span text:style-name="T75">FSFE. Public Money Public Code : Modernising Public Infrastructure with Free Software, 2019; </text:span><text:a xlink:type="simple" xlink:href="https://download.fsfe.org/campaigns/pmpc/PMPC-Modernising-with-Free-Software.pdf" text:style-name="Internet_20_link" text:visited-style-name="Visited_20_Internet_20_Link"><text:span text:style-name="T75">https://download.fsfe.org/campaigns/pmpc/PMPC-Modernising-with-Free-Software.pdf</text:span></text:a><text:bookmark-end text:name="__RefNumPara__709949_151231740"/></text:p>
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