api/.env

@@ -0,0 +1,33 @@
+# In all environments, the following files are loaded if they exist,
+# the latter taking precedence over the former:
+#
+#  * .env                contains default values for the environment variables needed by the app
+#  * .env.local          uncommitted file with local overrides
+#  * .env.$APP_ENV       committed environment-specific defaults
+#  * .env.$APP_ENV.local uncommitted environment-specific overrides
+#
+# Real environment variables win over .env files.
+#
+# DO NOT DEFINE PRODUCTION SECRETS IN THIS FILE NOR IN ANY OTHER COMMITTED FILES.
+# https://symfony.com/doc/current/configuration/secrets.html
+#
+# Run "composer dump-env prod" to compile .env files for production use (requires symfony/flex >=1.2).
+# https://symfony.com/doc/current/best_practices.html#use-environment-variables-for-infrastructure-configuration
+
+###> symfony/framework-bundle ###
+APP_ENV=dev
+APP_SECRET=2880857c2abf85444c6bd5a924771ce2
+###< symfony/framework-bundle ###
+
+###> doctrine/doctrine-bundle ###
+# Format described at https://www.doctrine-project.org/projects/doctrine-dbal/en/latest/reference/configuration.html#connecting-using-a-url
+# IMPORTANT: You MUST configure your server version, either here or in config/packages/doctrine.yaml
+#
+# DATABASE_URL="sqlite:///%kernel.project_dir%/var/data.db"
+# DATABASE_URL="mysql://app:!ChangeMe!@127.0.0.1:3306/app?serverVersion=8&charset=utf8mb4"
+DATABASE_URL="postgresql://caterpillar:!ChangeMe!@127.0.0.1:5432/catterpillar?serverVersion=14&charset=utf8"
+###< doctrine/doctrine-bundle ###
+
+###> nelmio/cors-bundle ###
+CORS_ALLOW_ORIGIN='^https?://(localhost|127\.0\.0\.1)(:[0-9]+)?$'
+###< nelmio/cors-bundle ###

api/.gitignore

@@ -0,0 +1,10 @@
+
+###> symfony/framework-bundle ###
+/.env.local
+/.env.local.php
+/.env.*.local
+/config/secrets/prod/prod.decrypt.private.php
+/public/bundles/
+/var/
+/vendor/
+###< symfony/framework-bundle ###

api/bin/console

@@ -0,0 +1,17 @@
+#!/usr/bin/env php
+<?php
+
+use App\Kernel;
+use Symfony\Bundle\FrameworkBundle\Console\Application;
+
+if (!is_file(dirname(__DIR__).'/vendor/autoload_runtime.php')) {
+    throw new LogicException('Symfony Runtime is missing. Try running "composer require symfony/runtime".');
+}
+
+require_once dirname(__DIR__).'/vendor/autoload_runtime.php';
+
+return function (array $context) {
+    $kernel = new Kernel($context['APP_ENV'], (bool) $context['APP_DEBUG']);
+
+    return new Application($kernel);
+};

api/composer.json

@@ -0,0 +1,87 @@
+{
+    "type": "project",
+    "license": "proprietary",
+    "minimum-stability": "stable",
+    "prefer-stable": true,
+    "require": {
+        "php": ">=8.1",
+        "ext-ctype": "*",
+        "ext-iconv": "*",
+        "api-platform/core": "^3.0",
+        "doctrine/annotations": "^1.0",
+        "doctrine/doctrine-bundle": "^2.7",
+        "doctrine/doctrine-migrations-bundle": "^3.2",
+        "doctrine/orm": "^2.13",
+        "nelmio/cors-bundle": "^2.2",
+        "phpdocumentor/reflection-docblock": "^5.3",
+        "phpstan/phpdoc-parser": "^1.8",
+        "symfony/asset": "6.1.*",
+        "symfony/console": "6.1.*",
+        "symfony/dotenv": "6.1.*",
+        "symfony/expression-language": "6.1.*",
+        "symfony/flex": "^2",
+        "symfony/framework-bundle": "6.1.*",
+        "symfony/property-access": "6.1.*",
+        "symfony/property-info": "6.1.*",
+        "symfony/proxy-manager-bridge": "6.1.*",
+        "symfony/runtime": "6.1.*",
+        "symfony/security-bundle": "6.1.*",
+        "symfony/serializer": "6.1.*",
+        "symfony/twig-bundle": "6.1.*",
+        "symfony/validator": "6.1.*",
+        "symfony/yaml": "6.1.*",
+        "webonyx/graphql-php": "^14.11"
+    },
+    "config": {
+        "allow-plugins": {
+            "composer/package-versions-deprecated": true,
+            "symfony/flex": true,
+            "symfony/runtime": true
+        },
+        "optimize-autoloader": true,
+        "preferred-install": {
+            "*": "dist"
+        },
+        "sort-packages": true
+    },
+    "autoload": {
+        "psr-4": {
+            "App\\": "src/"
+        }
+    },
+    "autoload-dev": {
+        "psr-4": {
+            "App\\Tests\\": "tests/"
+        }
+    },
+    "replace": {
+        "symfony/polyfill-ctype": "*",
+        "symfony/polyfill-iconv": "*",
+        "symfony/polyfill-php72": "*",
+        "symfony/polyfill-php73": "*",
+        "symfony/polyfill-php74": "*",
+        "symfony/polyfill-php80": "*",
+        "symfony/polyfill-php81": "*"
+    },
+    "scripts": {
+        "auto-scripts": {
+            "cache:clear": "symfony-cmd",
+            "assets:install %PUBLIC_DIR%": "symfony-cmd"
+        },
+        "post-install-cmd": [
+            "@auto-scripts"
+        ],
+        "post-update-cmd": [
+            "@auto-scripts"
+        ]
+    },
+    "conflict": {
+        "symfony/symfony": "*"
+    },
+    "extra": {
+        "symfony": {
+            "allow-contrib": false,
+            "require": "6.1.*"
+        }
+    }
+}

api/config/bundles.php

@@ -0,0 +1,11 @@
+<?php
+
+return [
+    Symfony\Bundle\FrameworkBundle\FrameworkBundle::class => ['all' => true],
+    Symfony\Bundle\TwigBundle\TwigBundle::class => ['all' => true],
+    Symfony\Bundle\SecurityBundle\SecurityBundle::class => ['all' => true],
+    Doctrine\Bundle\DoctrineBundle\DoctrineBundle::class => ['all' => true],
+    Doctrine\Bundle\MigrationsBundle\DoctrineMigrationsBundle::class => ['all' => true],
+    Nelmio\CorsBundle\NelmioCorsBundle::class => ['all' => true],
+    ApiPlatform\Symfony\Bundle\ApiPlatformBundle::class => ['all' => true],
+];

api/config/packages/api_platform.yaml

@@ -0,0 +1,8 @@
+api_platform:
+    title: Caterpillar API
+    version: 0.0.0
+    # Good cache defaults for REST APIs
+    defaults:
+        stateless: true
+        cache_headers:
+            vary: ['Content-Type', 'Authorization', 'Origin']

api/config/packages/cache.yaml

@@ -0,0 +1,19 @@
+framework:
+    cache:
+        # Unique name of your app: used to compute stable namespaces for cache keys.
+        #prefix_seed: your_vendor_name/app_name
+
+        # The "app" cache stores to the filesystem by default.
+        # The data in this cache should persist between deploys.
+        # Other options include:
+
+        # Redis
+        #app: cache.adapter.redis
+        #default_redis_provider: redis://localhost
+
+        # APCu (not recommended with heavy random-write workloads as memory fragmentation can cause perf issues)
+        #app: cache.adapter.apcu
+
+        # Namespaced pools use the above "app" backend by default
+        #pools:
+            #my.dedicated.cache: null

api/config/packages/doctrine.yaml

@@ -0,0 +1,42 @@
+doctrine:
+    dbal:
+        url: '%env(resolve:DATABASE_URL)%'
+
+        # IMPORTANT: You MUST configure your server version,
+        # either here or in the DATABASE_URL env var (see .env file)
+        #server_version: '13'
+    orm:
+        auto_generate_proxy_classes: true
+        naming_strategy: doctrine.orm.naming_strategy.underscore_number_aware
+        auto_mapping: true
+        mappings:
+            App:
+                is_bundle: false
+                dir: '%kernel.project_dir%/src/Entity'
+                prefix: 'App\Entity'
+                alias: App
+
+when@test:
+    doctrine:
+        dbal:
+            # "TEST_TOKEN" is typically set by ParaTest
+            dbname_suffix: '_test%env(default::TEST_TOKEN)%'
+
+when@prod:
+    doctrine:
+        orm:
+            auto_generate_proxy_classes: false
+            query_cache_driver:
+                type: pool
+                pool: doctrine.system_cache_pool
+            result_cache_driver:
+                type: pool
+                pool: doctrine.result_cache_pool
+
+    framework:
+        cache:
+            pools:
+                doctrine.result_cache_pool:
+                    adapter: cache.app
+                doctrine.system_cache_pool:
+                    adapter: cache.system

api/config/packages/doctrine_migrations.yaml

@@ -0,0 +1,6 @@
+doctrine_migrations:
+    migrations_paths:
+        # namespace is arbitrary but should be different from App\Migrations
+        # as migrations classes should NOT be autoloaded
+        'DoctrineMigrations': '%kernel.project_dir%/migrations'
+    enable_profiler: false

api/config/packages/framework.yaml

@@ -0,0 +1,24 @@
+# see https://symfony.com/doc/current/reference/configuration/framework.html
+framework:
+    secret: '%env(APP_SECRET)%'
+    #csrf_protection: true
+    http_method_override: false
+
+    # Enables session support. Note that the session will ONLY be started if you read or write from it.
+    # Remove or comment this section to explicitly disable session support.
+    session:
+        handler_id: null
+        cookie_secure: auto
+        cookie_samesite: lax
+        storage_factory_id: session.storage.factory.native
+
+    #esi: true
+    #fragments: true
+    php_errors:
+        log: true
+
+when@test:
+    framework:
+        test: true
+        session:
+            storage_factory_id: session.storage.factory.mock_file

api/config/packages/nelmio_cors.yaml

@@ -0,0 +1,10 @@
+nelmio_cors:
+    defaults:
+        origin_regex: true
+        allow_origin: ['%env(CORS_ALLOW_ORIGIN)%']
+        allow_methods: ['GET', 'OPTIONS', 'POST', 'PUT', 'PATCH', 'DELETE']
+        allow_headers: ['Content-Type', 'Authorization']
+        expose_headers: ['Link']
+        max_age: 3600
+    paths:
+        '^/': null

api/config/packages/routing.yaml

@@ -0,0 +1,12 @@
+framework:
+    router:
+        utf8: true
+
+        # Configure how to generate URLs in non-HTTP contexts, such as CLI commands.
+        # See https://symfony.com/doc/current/routing.html#generating-urls-in-commands
+        #default_uri: http://localhost
+
+when@prod:
+    framework:
+        router:
+            strict_requirements: null

api/config/packages/security.yaml

@@ -0,0 +1,39 @@
+security:
+    # https://symfony.com/doc/current/security.html#registering-the-user-hashing-passwords
+    password_hashers:
+        Symfony\Component\Security\Core\User\PasswordAuthenticatedUserInterface: 'auto'
+    # https://symfony.com/doc/current/security.html#loading-the-user-the-user-provider
+    providers:
+        users_in_memory: { memory: null }
+    firewalls:
+        dev:
+            pattern: ^/(_(profiler|wdt)|css|images|js)/
+            security: false
+        main:
+            lazy: true
+            provider: users_in_memory
+
+            # activate different ways to authenticate
+            # https://symfony.com/doc/current/security.html#the-firewall
+
+            # https://symfony.com/doc/current/security/impersonating_user.html
+            # switch_user: true
+
+    # Easy way to control access for large sections of your site
+    # Note: Only the *first* access control that matches will be used
+    access_control:
+        # - { path: ^/admin, roles: ROLE_ADMIN }
+        # - { path: ^/profile, roles: ROLE_USER }
+
+when@test:
+    security:
+        password_hashers:
+            # By default, password hashers are resource intensive and take time. This is
+            # important to generate secure password hashes. In tests however, secure hashes
+            # are not important, waste resources and increase test times. The following
+            # reduces the work factor to the lowest possible values.
+            Symfony\Component\Security\Core\User\PasswordAuthenticatedUserInterface:
+                algorithm: auto
+                cost: 4 # Lowest possible value for bcrypt
+                time_cost: 3 # Lowest possible value for argon
+                memory_cost: 10 # Lowest possible value for argon

api/config/packages/twig.yaml

@@ -0,0 +1,6 @@
+twig:
+    default_path: '%kernel.project_dir%/templates'
+
+when@test:
+    twig:
+        strict_variables: true

api/config/packages/validator.yaml

@@ -0,0 +1,13 @@
+framework:
+    validation:
+        email_validation_mode: html5
+
+        # Enables validator auto-mapping support.
+        # For instance, basic validation constraints will be inferred from Doctrine's metadata.
+        #auto_mapping:
+        #    App\Entity\: []
+
+when@test:
+    framework:
+        validation:
+            not_compromised_password: false

api/config/preload.php

@@ -0,0 +1,5 @@
+<?php
+
+if (file_exists(dirname(__DIR__).'/var/cache/prod/App_KernelProdContainer.preload.php')) {
+    require dirname(__DIR__).'/var/cache/prod/App_KernelProdContainer.preload.php';
+}

api/config/routes.yaml

@@ -0,0 +1,3 @@
+controllers:
+    resource: ../src/Controller/
+    type: attribute

api/config/routes/api_platform.yaml

@@ -0,0 +1,4 @@
+api_platform:
+    resource: .
+    type: api_platform
+    prefix: /api

api/config/routes/framework.yaml

@@ -0,0 +1,4 @@
+when@dev:
+    _errors:
+        resource: '@FrameworkBundle/Resources/config/routing/errors.xml'
+        prefix: /_error

api/config/services.yaml

@@ -0,0 +1,24 @@
+# This file is the entry point to configure your own services.
+# Files in the packages/ subdirectory configure your dependencies.
+
+# Put parameters here that don't need to change on each machine where the app is deployed
+# https://symfony.com/doc/current/best_practices.html#use-parameters-for-application-configuration
+parameters:
+
+services:
+    # default configuration for services in *this* file
+    _defaults:
+        autowire: true      # Automatically injects dependencies in your services.
+        autoconfigure: true # Automatically registers your services as commands, event subscribers, etc.
+
+    # makes classes in src/ available to be used as services
+    # this creates a service per class whose id is the fully-qualified class name
+    App\:
+        resource: '../src/'
+        exclude:
+            - '../src/DependencyInjection/'
+            - '../src/Entity/'
+            - '../src/Kernel.php'
+
+    # add more service definitions when explicit configuration is needed
+    # please note that last definitions always *replace* previous ones

api/data/database.links.txt

@@ -0,0 +1,8 @@
+CIS_bdpm.txt
+CIS_CIP_bdpm.txt
+CIS_COMPO_bdpm.txt
+CIS_HAS_SMR_bdpm.txt
+CIS_HAS_ASMR_bdpm.txt
+HAS_LiensPageCT_bdpm.txt
+CIS_CPD_bdpm.txt
+CIS_InfoImportantes.txt

api/data/utils/fill_database.php

@@ -0,0 +1,20 @@
+<?php
+
+/**
+ * Fill API backend SQL database with data from government open data.
+ */
+
+// CIS_bdpm.txt
+// This database holds the list of medicines with status, holder, name, etc.
+
+$URL = "http://localhost/";
+
+function post($url, $data) {
+    $ch = curl_init($url);
+    curl_setopt($ch, CURLOPT_POST, true);
+    curl_setopt($ch, CURLOPT_POSTFIELDS, $data);
+    curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
+    $response = curl_exec($ch);
+    curl_close($ch);
+    return $response;
+}

api/data/utils/get_database.sh

@@ -0,0 +1,12 @@
+#! /usr/bin/env bash
+set -e
+
+DATABASE_DOWNLOAD_ENDPOINT="https://base-donnees-publique.medicaments.gouv.fr/telechargement.php?fichier="
+
+for file in $(cat ./data/database.links.txt); do
+    if [[ -z "$file" ]]; then
+        continue
+    fi
+    echo "Downloading $file"
+    wget -O "./data/bdpm/${file}" "${DATABASE_DOWNLOAD_ENDPOINT}${file}"
+done

api/docker-compose.override.yml

@@ -0,0 +1,8 @@
+version: '3'
+
+services:
+###> doctrine/doctrine-bundle ###
+  database:
+    ports:
+      - "5432"
+###< doctrine/doctrine-bundle ###

api/docker-compose.yml

@@ -0,0 +1,21 @@
+version: '3'
+
+services:
+###> doctrine/doctrine-bundle ###
+  database:
+    image: postgres:${POSTGRES_VERSION:-14}-alpine
+    environment:
+      POSTGRES_DB: ${POSTGRES_DB:-app}
+      # You should definitely change the password in production
+      POSTGRES_PASSWORD: ${POSTGRES_PASSWORD:-!ChangeMe!}
+      POSTGRES_USER: ${POSTGRES_USER:-app}
+    volumes:
+      - db-data:/var/lib/postgresql/data:rw
+      # You may use a bind-mounted host directory instead, so that it is harder to accidentally remove the volume and lose all your data!
+      # - ./docker/db/data:/var/lib/postgresql/data:rw
+###< doctrine/doctrine-bundle ###
+
+volumes:
+###> doctrine/doctrine-bundle ###
+  db-data:
+###< doctrine/doctrine-bundle ###

api/migrations/.gitignore

@@ -0,0 +1 @@
+*

api/public/index.php

@@ -0,0 +1,9 @@
+<?php
+
+use App\Kernel;
+
+require_once dirname(__DIR__).'/vendor/autoload_runtime.php';
+
+return function (array $context) {
+    return new Kernel($context['APP_ENV'], (bool) $context['APP_DEBUG']);
+};

api/src/Entity/MedicineAdministrationWay.php

@@ -0,0 +1,50 @@
+<?php
+
+namespace App\Entity;
+
+use ApiPlatform\Metadata\ApiResource;
+use ApiPlatform\Metadata\Link;
+use Doctrine\Common\Collections\ArrayCollection;
+use Doctrine\ORM\Mapping as ORM;
+
+/**
+ * A medicine administration way.
+ * i.e. "comprime secable voie orale" for instance
+ */
+#[ORM\Entity]
+class MedicineAdministrationWay
+{
+    #[ORM\Id, ORM\Column,ORM\GeneratedValue]
+    private ?int $id = null;
+
+    /**
+     * This CIS (Code Identifiant de Spécialité) id is the unique identifier of the medicine.
+     */
+    #[ORM\Column]
+    private ?string $CIS = null;
+
+    /** The medicine that is admnistrate this way. */
+    #[ORM\ManyToOne(inversedBy: 'ways')]
+    public ?MedicineSpeciality $medicine = null;
+
+    /**
+     * The drug administration way
+     */
+    #[ORM\Column]
+    private ?string $administration_way = null;
+
+    public function getId(): ?int
+    {
+        return $this->id;
+    }
+
+    public function getCIS(): ?string
+    {
+        return $this->CIS;
+    }
+
+    public function getAdministrationWay(): ?string
+    {
+        return $this->administration_way;
+    }
+}

api/src/Entity/MedicineHolder.php

@@ -0,0 +1,67 @@
+<?php
+
+namespace App\Entity;
+
+use ApiPlatform\Metadata\ApiResource;
+use ApiPlatform\Metadata\Link;
+use Doctrine\ORM\Mapping as ORM;
+
+/**
+ * A medicine holder (titulaire of an AMM).
+ */
+#[ORM\Entity]
+class MedicineHolder
+{
+    #[ORM\Id]
+    #[ORM\GeneratedValue]
+    #[ORM\Column(type: 'integer')]
+    private ?int $id = null;
+
+    /**
+     * This CIS (Code Identifiant de Spécialité) id is the unique identifier of the medicine.
+     */
+    #[ORM\Column(type: 'string', length: 11)]
+    private ?string $CIS = null;
+
+    #[ORM\Column]
+    private string $name = '';
+
+    /** The medicament this entity holds */
+    #[ORM\ManyToOne(inversedBy: 'holders')]
+    private ?MedicineSpeciality $medicine;
+
+    public function getId(): ?int
+    {
+        return $this->id;
+    }
+
+    public function getCIS(): ?string
+    {
+        return $this->CIS;
+    }
+
+    public function getName(): ?string
+    {
+        return $this->name;
+    }
+
+
+    public function setCIS(string $CIS): self
+    {
+        $this->CIS = $CIS;
+
+        return $this;
+    }
+
+    public function setName(string $name): self
+    {
+        $this->name = $name;
+
+        return $this;
+    }
+
+    public function __toString(): string
+    {
+        return $this->name;
+    }
+}

api/src/Entity/MedicineSpeciality.php

@@ -0,0 +1,295 @@
+<?php
+
+namespace App\Entity;
+
+use ApiPlatform\Metadata\ApiResource;
+use ApiPlatform\Metadata\ApiProperty;
+use ApiPlatform\Metadata\Link;
+use Doctrine\Common\Collections\ArrayCollection;
+use Doctrine\ORM\Mapping as ORM;
+
+/**
+ * A medicine speciality.
+ *
+ * Medicine that is in the commercial distribution or that has been in commercial distribution since less than three years.
+ *
+ * From CIS_bdpm.txt
+ * @see https://base-donnees-publique.medicaments.gouv.fr/telechargement.php
+ */
+#[ORM\Entity]
+#[ApiResource]
+// #[ApiResource(
+//     uriTemplate: '/medicine/'
+// )]
+// #[ApiResource(
+//     uriTemplate: '/medicine/{CIS}',
+//     uriVariables: [
+//         'CIS' => new Link(fromClass: MedicineSpeciality::class, fromProperty: 'CIS'),
+//     ]
+// )]
+// #[ApiResource(
+//     uriTemplate: '/medicine/{CIS}/holder',
+//     uriVariables: [
+//         'CIS' => new Link(fromClass: MedicineSpeciality::class, fromProperty: 'CIS'),
+//     ]
+// )]
+// #[ApiResource(
+//     uriTemplate: '/medicine/{CIS}/holder/{id}',
+//     uriVariables: [
+//         'CIS' => new Link(fromClass: MedicineSpeciality::class, fromProperty: 'CIS'),
+//         'id' => new Link(fromClass: MedicineHolder::class, fromProperty: 'id'),
+//     ]
+// )]
+// #[ApiResource(
+//     uriTemplate: '/medicine/{CIS}/way',
+//     uriVariables: [
+//         'CIS' => new Link(fromClass: MedicineSpeciality::class, fromProperty: 'CIS'),
+//     ]
+// )]
+// #[ApiResource(
+//     uriTemplate: '/medicine/{CIS}/way/{id}',
+//     uriVariables: [
+//         'CIS' => new Link(fromClass: MedicineSpeciality::class, fromProperty: 'CIS'),
+//         'id' => new Link(fromClass: MedicineAdministrationWay::class, fromProperty: 'id'),
+//     ]
+// )]
+class MedicineSpeciality
+{
+
+    #[ORM\Id, ORM\Column,ORM\GeneratedValue]
+    private ?int $id = null;
+
+    /**
+     * This CIS (Code Identifiant de Spécialité) id is the unique identifier of the medicine.
+     */
+    #[ORM\Column]
+    #[ApiProperty(identifier: true)]
+    private ?int $CIS = null;
+
+    /**
+     * Name of the medicine.
+     */
+    #[ORM\Column]
+    private ?string $denomination = null;
+
+    /**
+     * Pharmaceutical form of the medicine.
+     *
+     *
+     */
+    #[ORM\Column]
+    private ?string $form = null;
+
+    /**
+     * Ways of drug administration of the medicine.
+     * @var medicineAdministrationWay[] Available administration routes for this medicine.
+     */
+    #[ORM\OneToMany(mappedBy: 'medicine', targetEntity: MedicineAdministrationWay::class)]
+    public iterable $ways;
+
+    /**
+     * Administrative state of medicine's market authorization (AMM).
+     */
+    #[ORM\Column]
+    private ?string $market_auth_status = null;
+
+    /**
+     * Type of medicine market authorization process
+     */
+    #[ORM\Column]
+    private ?string $market_auth_process_type = null;
+
+    /**
+     * Date of medicine market authorization (AMM - * Autorisation de Mise sur le Marché)
+     */
+    #[ORM\Column(type: 'date')]
+    private ?\DateTimeInterface $market_auth_date = null;
+
+    /**
+     * Market status
+     *
+     * State of medicine commercialization.
+     */
+    #[ORM\Column]
+    private ?string $market_status = null;
+
+    /**
+     * Bdm status
+     *
+     * either "alerte", "warning disponibilité"
+     */
+    #[ORM\Column]
+    private ?string $bdm_status = null;
+
+    /**
+     * European authorization code
+     */
+    #[ORM\Column]
+    private ?int $european_auth_code = null;
+
+    /**
+     * Holders(s)
+     *
+     * @var MedicineHolder[] Holders of the medicine market authorization (AMM)
+     */
+    #[ORM\OneToMany(mappedBy: 'medicine', targetEntity: MedicineHolder::class, cascade: ['persist', 'remove'])]
+    public iterable $holders;
+
+    /**
+     * Enforced surveillance
+     *
+     * either 'Oui' or 'Non'
+     */
+    #[ORM\Column]
+    private ?string $enforced_surveillance = null;
+
+    public function __construct()
+    {
+        $this->holders = new ArrayCollection();
+        $this->ways = new ArrayCollection();
+    }
+
+    public function getCIS(): ?int
+    {
+        return $this->CIS;
+    }
+
+    public function getDenomination(): ?string
+    {
+        return $this->denomination;
+    }
+
+    public function getForm(): ?string
+    {
+        return $this->form;
+    }
+
+    public function getMarketAuthStatus(): ?string
+    {
+        return $this->market_auth_status;
+    }
+
+    public function getMarketAuthProcessType(): ?string
+    {
+        return $this->market_auth_process_type;
+    }
+
+    public function getMarketAuthDate(): ?\DateTimeInterface
+    {
+        return $this->market_auth_date;
+    }
+
+    public function getMarketStatus(): ?string
+    {
+        return $this->market_status;
+    }
+
+    public function getBdmStatus(): ?string
+    {
+        return $this->bdm_status;
+    }
+
+    public function getEuropeanAuthCode(): ?int
+    {
+        return $this->european_auth_code;
+    }
+
+    public function getEnforcedSurveillance(): ?string
+    {
+        return $this->enforced_surveillance;
+    }
+
+    public function getWays(): iterable
+    {
+        return $this->ways;
+    }
+
+    public function getHolders(): iterable
+    {
+        return $this->holders;
+    }
+
+    public function setCIS(?int $CIS): self
+    {
+        $this->CIS = $CIS;
+
+        return $this;
+    }
+
+    public function setDenomination(?string $denomination): self
+    {
+        $this->denomination = $denomination;
+
+        return $this;
+    }
+
+    public function setForm(?string $form): self
+    {
+        $this->form = $form;
+
+        return $this;
+    }
+
+    public function setMarketAuthStatus(?string $market_auth_status): self
+    {
+        $this->market_auth_status = $market_auth_status;
+
+        return $this;
+    }
+
+    public function setMarketAuthProcessType(?string $market_auth_process_type): self
+    {
+        $this->market_auth_process_type = $market_auth_process_type;
+
+        return $this;
+    }
+
+    public function setMarketAuthDate(?\DateTimeInterface $market_auth_date): self
+    {
+        $this->market_auth_date = $market_auth_date;
+
+        return $this;
+    }
+
+    public function setMarketStatus(?string $market_status): self
+    {
+        $this->market_status = $market_status;
+
+        return $this;
+    }
+
+    public function setBdmStatus(?string $bdm_status): self
+    {
+        $this->bdm_status = $bdm_status;
+
+        return $this;
+    }
+
+    public function setEuropeanAuthCode(?int $european_auth_code): self
+    {
+        $this->european_auth_code = $european_auth_code;
+
+        return $this;
+    }
+
+    public function setEnforcedSurveillance(?string $enforced_surveillance): self
+    {
+        $this->enforced_surveillance = $enforced_surveillance;
+
+        return $this;
+    }
+
+    public function setWays(iterable $ways): self
+    {
+        $this->ways = $ways;
+
+        return $this;
+    }
+
+    public function setHolders(iterable $holders): self
+    {
+        $this->holders = $holders;
+
+        return $this;
+    }
+}

api/src/Kernel.php

@@ -0,0 +1,11 @@
+<?php
+
+namespace App;
+
+use Symfony\Bundle\FrameworkBundle\Kernel\MicroKernelTrait;
+use Symfony\Component\HttpKernel\Kernel as BaseKernel;
+
+class Kernel extends BaseKernel
+{
+    use MicroKernelTrait;
+}

api/symfony.lock

@@ -0,0 +1,156 @@
+{
+    "api-platform/core": {
+        "version": "3.0",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "3.0",
+            "ref": "0330386d716d3eecc52ee5ac66976e733eb8f961"
+        },
+        "files": [
+            "config/routes/api_platform.yaml",
+            "src/ApiResource/.gitignore"
+        ]
+    },
+    "doctrine/annotations": {
+        "version": "1.13",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "1.10",
+            "ref": "64d8583af5ea57b7afa4aba4b159907f3a148b05"
+        }
+    },
+    "doctrine/doctrine-bundle": {
+        "version": "2.7",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "2.4",
+            "ref": "da713d006953b90d1c085c1be480ecdd6c4a95e0"
+        },
+        "files": [
+            "config/packages/doctrine.yaml",
+            "src/Entity/.gitignore",
+            "src/Repository/.gitignore"
+        ]
+    },
+    "doctrine/doctrine-migrations-bundle": {
+        "version": "3.2",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "3.1",
+            "ref": "1d01ec03c6ecbd67c3375c5478c9a423ae5d6a33"
+        },
+        "files": [
+            "config/packages/doctrine_migrations.yaml",
+            "migrations/.gitignore"
+        ]
+    },
+    "nelmio/cors-bundle": {
+        "version": "2.2",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "1.5",
+            "ref": "6bea22e6c564fba3a1391615cada1437d0bde39c"
+        },
+        "files": [
+            "config/packages/nelmio_cors.yaml"
+        ]
+    },
+    "symfony/console": {
+        "version": "6.1",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "5.3",
+            "ref": "da0c8be8157600ad34f10ff0c9cc91232522e047"
+        },
+        "files": [
+            "bin/console"
+        ]
+    },
+    "symfony/flex": {
+        "version": "2.2",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "1.0",
+            "ref": "146251ae39e06a95be0fe3d13c807bcf3938b172"
+        },
+        "files": [
+            ".env"
+        ]
+    },
+    "symfony/framework-bundle": {
+        "version": "6.1",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "5.4",
+            "ref": "3cd216a4d007b78d8554d44a5b1c0a446dab24fb"
+        },
+        "files": [
+            "config/packages/cache.yaml",
+            "config/packages/framework.yaml",
+            "config/preload.php",
+            "config/routes/framework.yaml",
+            "config/services.yaml",
+            "public/index.php",
+            "src/Controller/.gitignore",
+            "src/Kernel.php"
+        ]
+    },
+    "symfony/routing": {
+        "version": "6.1",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "6.1",
+            "ref": "a44010c0d06989bd4f154aa07d2542d47caf5b83"
+        },
+        "files": [
+            "config/packages/routing.yaml",
+            "config/routes.yaml"
+        ]
+    },
+    "symfony/security-bundle": {
+        "version": "6.1",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "6.0",
+            "ref": "8a5b112826f7d3d5b07027f93786ae11a1c7de48"
+        },
+        "files": [
+            "config/packages/security.yaml"
+        ]
+    },
+    "symfony/twig-bundle": {
+        "version": "6.1",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "5.4",
+            "ref": "bb2178c57eee79e6be0b297aa96fc0c0def81387"
+        },
+        "files": [
+            "config/packages/twig.yaml",
+            "templates/base.html.twig"
+        ]
+    },
+    "symfony/validator": {
+        "version": "6.1",
+        "recipe": {
+            "repo": "github.com/symfony/recipes",
+            "branch": "main",
+            "version": "5.3",
+            "ref": "c32cfd98f714894c4f128bb99aa2530c1227603c"
+        },
+        "files": [
+            "config/packages/validator.yaml"
+        ]
+    }
+}

api/templates/base.html.twig

@@ -0,0 +1,19 @@
+<!DOCTYPE html>
+<html>
+    <head>
+        <meta charset="UTF-8">
+        <title>{% block title %}Welcome!{% endblock %}</title>
+        <link rel="icon" href="data:image/svg+xml,<svg xmlns=%22http://www.w3.org/2000/svg%22 viewBox=%220 0 128 128%22><text y=%221.2em%22 font-size=%2296%22>⚫️</text></svg>">
+        {# Run `composer require symfony/webpack-encore-bundle` to start using Symfony UX #}
+        {% block stylesheets %}
+            {{ encore_entry_link_tags('app') }}
+        {% endblock %}
+
+        {% block javascripts %}
+            {{ encore_entry_script_tags('app') }}
+        {% endblock %}
+    </head>
+    <body>
+        {% block body %}{% endblock %}
+    </body>
+</html>